SLCO1B7

Summary

SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative), HGNC:32934) is a unprocessed pseudogene on chromosome 12p12.2.

Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane.

Source: NCBI Gene 338821 — RefSeq curated summary.

At a glance

• Gene type: non-coding (transcribed_unprocessed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32934
Approved symbol	SLCO1B7
Name	solute carrier organic anion transporter family member 1B7 (putative)
Location	12p12.2
Locus type	gene with protein product
Status	Approved
Aliases	LST3, SLC21A21
Ensembl gene	ENSG00000205754
Ensembl biotype	transcribed_unprocessed_pseudogene
OMIM	619875
Entrez	338821

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_unprocessed_pseudogene

ENST00000648739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000648739 — 14 exons

Exon	Start	End
ENSE00003831309	21067319	21067383
ENSE00003831347	21023189	21023287
ENSE00003831753	21047053	21047217
ENSE00003832925	21048712	21048907
ENSE00003833154	21076452	21076569
ENSE00003834816	21022850	21022996
ENSE00003835487	20962768	20962851
ENSE00003835823	21089908	21090106
ENSE00003837593	21054452	21054636
ENSE00003838367	21021461	21021582
ENSE00003838730	21043334	21043576
ENSE00003839126	21015639	21015780
ENSE00003839982	21019248	21019380
ENSE00003840168	21052096	21052261

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 83.72.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.72	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.11	gold quality
right lobe of liver	UBERON:0001114	68.47	gold quality
liver	UBERON:0002107	64.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	40.93	gold quality
corpus callosum	UBERON:0002336	40.47	silver quality
endocervix	UBERON:0000458	37.62	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
bone marrow	UBERON:0002371	35.81	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
monocyte	CL:0000576	35.44	gold quality
right testis	UBERON:0004534	35.19	gold quality
leukocyte	CL:0000738	34.73	gold quality
testis	UBERON:0000473	34.59	gold quality
left testis	UBERON:0004533	33.65	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
gall bladder	UBERON:0002110	33.38	gold quality
superior frontal gyrus	UBERON:0002661	33.00	gold quality
tibial nerve	UBERON:0001323	32.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
endometrium	UBERON:0001295	31.20	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
placenta	UBERON:0001987	30.31	gold quality
uterine cervix	UBERON:0000002	30.08	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
saliva-secreting gland	UBERON:0001044	29.81	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6142	no	3.57
E-ANND-3	no	2.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• This study investigated the expression and function of LST-3TM12 as a member of a multigene family. (PMID:29248594)
• Results showed that OATP1B3-1B7 interacts with several drugs. One of the identified inhibitors was ezetimibe, which is also a substrate ofOATP1B3-1B7. Moreover, ezetimibe glucuronidation rates were decreased by bromsulphthalein, which is a OATP1B3-1B7 inhibitor. Thus, OATP1B3- 1B7 may function as a smooth endoplasmic reticulum gateway for ezetimibe. (PMID:31127008)
• Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7. (PMID:32818652)
• circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis. (PMID:38015711)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.