SLCO3A1

Summary

SLCO3A1 (solute carrier organic anion transporter family member 3A1, HGNC:10952) is a protein-coding gene on chromosome 15q26.1, encoding Solute carrier organic anion transporter family member 3A1 (Q9UIG8). Putative organic anion antiporter with apparent broad substrate specificity.

Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of MAPK cascade; positive regulation of canonical NF-kappaB signal transduction; and prostaglandin transport. Located in basal plasma membrane.

Source: NCBI Gene 28232 — RefSeq curated summary.

At a glance

• GWAS associations: 19
• Clinical variants (ClinVar): 89 total
• Druggable target: yes
• MANE Select transcript: NM_013272

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10952
Approved symbol	SLCO3A1
Name	solute carrier organic anion transporter family member 3A1
Location	15q26.1
Locus type	gene with protein product
Status	Approved
Aliases	OATP-D, OATP3A1
Ensembl gene	ENSG00000176463
Ensembl biotype	protein_coding
OMIM	612435
Entrez	28232

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 5 protein_coding_CDS_not_defined, 3 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000318445, ENST00000424469, ENST00000553304, ENST00000553653, ENST00000555111, ENST00000555210, ENST00000555513, ENST00000555549, ENST00000555769, ENST00000555892, ENST00000556649, ENST00000564072, ENST00000566477

RefSeq mRNA: 2 — MANE Select: NM_013272 NM_001145044, NM_013272

CCDS: CCDS10371, CCDS45354

Canonical transcript exons

ENST00000318445 — 10 exons

Exon	Start	End
ENSE00001290397	92162756	92165903
ENSE00001931253	91853708	91854088
ENSE00003461581	92146984	92147159
ENSE00003473391	92094881	92094979
ENSE00003504132	92150950	92151014
ENSE00003514793	92120465	92120629
ENSE00003519263	91915993	91916458
ENSE00003585655	92128351	92128489
ENSE00003637320	92126061	92126259
ENSE00003650915	92104279	92104542

Expression profiles

Bgee: expression breadth ubiquitous, 279 present calls, max score 95.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.2252 / max 315.2002, expressed in 1427 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
148585	8.1715	1387
148586	0.9032	453
148603	0.0829	35
148587	0.0410	9
148604	0.0136	8
148602	0.0130	3

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.41	gold quality
endothelial cell	CL:0000115	95.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.88	gold quality
inferior vagus X ganglion	UBERON:0005363	94.78	gold quality
blood	UBERON:0000178	94.14	gold quality
spinal cord	UBERON:0002240	94.14	gold quality
left testis	UBERON:0004533	94.01	gold quality
cervix squamous epithelium	UBERON:0006922	93.42	gold quality
right testis	UBERON:0004534	93.38	gold quality
sperm	CL:0000019	92.19	gold quality
testis	UBERON:0000473	92.09	gold quality
cortical plate	UBERON:0005343	91.93	gold quality
corpus callosum	UBERON:0002336	91.72	gold quality
visceral pleura	UBERON:0002401	91.72	gold quality
monocyte	CL:0000576	91.68	gold quality
cranial nerve II	UBERON:0000941	91.56	gold quality
apex of heart	UBERON:0002098	91.56	gold quality
leukocyte	CL:0000738	91.46	gold quality
heart left ventricle	UBERON:0002084	91.37	gold quality
mononuclear cell	CL:0000842	91.35	gold quality
pericardium	UBERON:0002407	91.34	gold quality
male germ cell	CL:0000015	91.31	gold quality
cardiac ventricle	UBERON:0002082	91.23	gold quality
granulocyte	CL:0000094	91.06	gold quality
right atrium auricular region	UBERON:0006631	91.00	gold quality
subthalamic nucleus	UBERON:0001906	90.88	gold quality
nipple	UBERON:0002030	90.75	gold quality
ventral tegmental area	UBERON:0002691	90.64	gold quality
medulla oblongata	UBERON:0001896	90.38	gold quality
skin of abdomen	UBERON:0001416	90.27	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	24.13
E-ANND-3	yes	9.98

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

144 targeting SLCO3A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-450B-5P	99.92	71.48	3175

Literature-anchored findings (GeneRIF, showing 9)

• OATP-D plays an important role in translocating prostaglandins in specialized tissues and cells. (PMID:14631946)
• Further evidence is provided for the involvement of OATPs in oligopeptide transport. OATP3A1 variants might be involved in the regulation of extracellular vasopressin concentration in human brain. (PMID:16971491)
• tissue-specific localization of OATP2B1, OATP3A1 and OATP5A1 has been analyzed in normal mammary tissue and corresponding breast cancer tissues. (PMID:21278488)
• Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar. (PMID:21486766)
• Single nucleotide polymorhpisms of SLCO3A1 were associated with nicotine dependence. (PMID:22377092)
• SLCO3A1, a novel Crohn’s disease-associated gene, mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation. (PMID:24945726)
• our results revealed altered OATP3A1 and OATP4A1 mRNA levels and novel mechanisms that might be involved in their regulation in colorectal cancer (PMID:26349991)
• OATP3A1 functions as a bile acid efflux transporter that is up-regulated as an adaptive response to cholestasis. (PMID:30063921)
• Tumor necrosis factor alpha upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis. (PMID:34971708)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	slco3a1a	ENSDARG00000018726
danio_rerio	slco3a1b	ENSDARG00000068296
mus_musculus	Slco3a1	ENSMUSG00000025790
rattus_norvegicus	Slco3a1	ENSRNOG00000032798
drosophila_melanogaster	Oatp30B	FBGN0032123

Paralogs (10): SLCO1A2 (ENSG00000084453), SLCO4A1 (ENSG00000101187), SLCO1B3 (ENSG00000111700), SLCO1B1 (ENSG00000134538), SLCO2B1 (ENSG00000137491), SLCO5A1 (ENSG00000137571), SLCO1C1 (ENSG00000139155), SLCO4C1 (ENSG00000173930), SLCO2A1 (ENSG00000174640), SLCO6A1 (ENSG00000205359)

Protein

Protein identifiers

Solute carrier organic anion transporter family member 3A1 — Q9UIG8 (reviewed: Q9UIG8)

Alternative names: Organic anion transporter polypeptide-related protein 3, Organic anion-transporting polypeptide D, PGE1 transporter, Sodium-independent organic anion transporter D, Solute carrier family 21 member 11

All UniProt accessions (4): Q9UIG8, G3V2B7, G3V3K4, H0YJM0

UniProt curated annotations — full annotation on UniProt →

Function. Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated. Mediates transport of tryptophan, phenyalanine and tyrosine. Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate. Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate. Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate.

Subcellular location. Basolateral cell membrane Apical cell membrane. Basal cell membrane Apical cell membrane.

Tissue specificity. Generally the expression of isoform 1 is higher than that of isoform 2. Expressed in placental trophoblasts. Expressed in pancreas, kidney, liver, lung, brain, heart, cerebellum, peripheral blood leukocyte, colon, small intestine, ovary, testis, prostate, thyroid, thymus and spleen. Expressed in fetal brain, heart, kidney, liver, lung, skeletal muscle, spleen and pancreas. In testis, detected in spermatogonia at different stages and absent from Sertoli cells. Expressed in the choroid plexus epithelium, at the basolateral membrane. In brain, also very abundant in the gray matter of the frontal cortex, but not associated with neuronal cell bodies. Not detected in the white matter. Expressed in heart, brain, cerebellum, testis, lung, thyroid, spoleen and liver. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed within the tubules. In testis, also present in spermatogonia at different stages. In brain, expressed in the choroid plexus epithelium, at the apical membrane as well as in the subapical intracellular vesicular compartments. In brain, also associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. Highly expressed in the brain and testis (at protein level). Ubiquitous.

Activity regulation. Stimulated by extracellular acidic pH.

Induction. Transcriptionally up-regulated by SP1 and RELA in response to FGF19.

Similarity. Belongs to the organo anion transporter (TC 2.A.60) family.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9UIG8-1	1, OATP3A1-v1	yes
Q9UIG8-2	2, OATP3A1-v2
Q9UIG8-3	3
Q9UIG8-4	4
Q9UIG8-5	5, OATP3A1-v3

RefSeq proteins (2): NP_001138516, NP_037404* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002350	Kazal_dom	Domain
IPR004156	OATP	Family
IPR036058	Kazal_dom_sf	Homologous_superfamily
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF03137, PF07648

Catalyzed reactions (Rhea), 12 shown:

• L-phenylalanine(in) = L-phenylalanine(out) (RHEA:27950)
• prostaglandin E1(out) = prostaglandin E1(in) (RHEA:50980)
• prostaglandin E2(out) = prostaglandin E2(in) (RHEA:50984)
• prostaglandin F2alpha(out) = prostaglandin F2alpha(in) (RHEA:50988)
• L-tyrosine(in) = L-tyrosine(out) (RHEA:68572)
• L-tryptophan(in) = L-tryptophan(out) (RHEA:70947)
• (5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in) (RHEA:71395)
• taurocholate(out) = taurocholate(in) (RHEA:71703)
• L-thyroxine(out) = L-thyroxine(in) (RHEA:71819)
• estrone 3-sulfate(out) = estrone 3-sulfate(in) (RHEA:71835)
• dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in) (RHEA:71839)
• glycocholate(out) = glycocholate(in) (RHEA:71851)

UniProt features (52 total): topological domain 13, transmembrane region 12, glycosylation site 7, splice variant 7, sequence conflict 4, disulfide bond 3, chain 1, domain 1, region of interest 1, compositionally biased region 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UIG8-F1	75.19	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Disulfide bonds (3): 471–501, 477–497, 486–511

Glycosylation sites (7): 153, 169, 381, 457, 502, 505, 519

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-879518	Organic anion transport by SLCO transporters

MSigDB gene sets: 0 (showing top):

GO Biological Process (11): monoatomic ion transport (GO:0006811), obsolete organic anion transport (GO:0015711), prostaglandin transport (GO:0015732), phenylalanine transport (GO:0015823), tryptophan transport (GO:0015827), tyrosine transport (GO:0015828), positive regulation of canonical NF-kappaB signal transduction (GO:0043123), sodium-independent organic anion transport (GO:0043252), positive regulation of MAPK cascade (GO:0043410), transport across blood-brain barrier (GO:0150104), transmembrane transport (GO:0055085)

GO Molecular Function (4): obsolete organic anion transmembrane transporter activity (GO:0008514), prostaglandin transmembrane transporter activity (GO:0015132), obsolete sodium-independent organic anion transmembrane transporter activity (GO:0015347), protein binding (GO:0005515)

GO Cellular Component (5): plasma membrane (GO:0005886), basal plasma membrane (GO:0009925), basolateral plasma membrane (GO:0016323), apical plasma membrane (GO:0016324), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
SLC-mediated transport of organic anions	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
plasma membrane region	3
transport	2
aromatic amino acid transport	2
positive regulation of intracellular signal transduction	2
fatty acid transport	1
icosanoid transport	1
carboxylic acid transport	1
nitrogen compound transport	1
amino acid transport	1
L-amino acid transport	1
canonical NF-kappaB signal transduction	1
regulation of canonical NF-kappaB signal transduction	1
transmembrane transport	1
MAPK cascade	1
regulation of MAPK cascade	1
vascular transport	1
cellular process	1
prostaglandin transport	1
icosanoid transmembrane transporter activity	1
binding	1
membrane	1
cell periphery	1
basal part of cell	1
basal plasma membrane	1
apical part of cell	1
cellular anatomical structure	1

Protein interactions and networks

STRING

928 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLCO3A1	SLC22A5	O76082	592
SLCO3A1	SLC22A8	Q8TCC7	571
SLCO3A1	SLC22A11	Q9NSA0	569
SLCO3A1	SLC22A4	Q9H015	567
SLCO3A1	SLC22A9	Q8IVM8	567
SLCO3A1	SLC22A7	Q9Y694	517
SLCO3A1	SLCO2B1	O94956	499
SLCO3A1	HSD17B2	P37059	496
SLCO3A1	SLC29A2	Q14542	488
SLCO3A1	ABCC4	O15439	481
SLCO3A1	SLC16A10	Q8TF71	481
SLCO3A1	SLC22A6	Q4U2R8	475
SLCO3A1	SLC16A2	P36021	474
SLCO3A1	SLC22A10	Q63ZE4	472
SLCO3A1	FRMD4A	Q9P2Q2	463

IntAct

3 interactions, top by confidence:

A	B	Type	Score
	NPC1	psi-mi:“MI:0914”(association)	0.350
SLCO3A1	STX6	psi-mi:“MI:0914”(association)	0.350

BioGRID (35): SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-RNA), SLCO3A1 (Two-hybrid), SLCO3A1 (Two-hybrid), SLCO3A1 (Two-hybrid), TUSC5 (Two-hybrid), SLCO3A1 (Proximity Label-MS), SLCO3A1 (Proximity Label-MS), SLCO3A1 (Proximity Label-MS), SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-MS), SLCO3A1 (Affinity Capture-MS)

ESM2 similar proteins: A1Z7R6, A2AWR3, A4IF94, A4IHK6, A5D7V7, B2RXV4, B2RYH9, O75387, P34711, P42557, P58355, P70187, Q09428, Q0P5V9, Q0VCM6, Q4LE88, Q5BK75, Q5BKX6, Q5F4B8, Q5RBM3, Q5RF58, Q5SR56, Q7Z3Q1, Q866G7, Q8BIV7, Q8BSM7, Q8C0T7, Q8CA03, Q8CGA3, Q8CIA9, Q8HYW2, Q8K0H7, Q8K4S3, Q8N370, Q8NBP5, Q8R3L5, Q96MC6, Q99624, Q99N02, Q9BY10

Diamond homologs: F5H094, G3V0H7, O35913, O88397, O94956, P46720, P46721, P70502, Q00910, Q5RFF0, Q6ZQN7, Q71MB6, Q8BGD4, Q8BXB6, Q8HYW2, Q8R3L5, Q91YY5, Q92959, Q96BD0, Q99J94, Q99N01, Q99N02, Q9EP96, Q9EPT5, Q9EPZ7, Q9ERB5, Q9GMU6, Q9H2Y9, Q9JHI3, Q9JJL3, Q9NPD5, Q9NYB5, Q9QXZ6, Q9QYE2, Q9QZX8, Q9UIG8, Q9Y6L6, Q8K078, Q86UG4, Q8C0X7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

89 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	67
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4551 predictions. Top by Δscore:

Variant	Effect	Δscore
15:91915990:CAG:C	acceptor_loss	1.0000
15:91915991:A:T	acceptor_loss	1.0000
15:91915991:AG:A	acceptor_gain	1.0000
15:91915991:AGGT:A	acceptor_gain	1.0000
15:91915992:GG:G	acceptor_gain	1.0000
15:91915992:GGT:G	acceptor_gain	1.0000
15:91915992:GGTG:G	acceptor_gain	1.0000
15:91915992:GGTGA:G	acceptor_gain	1.0000
15:91916436:G:GT	donor_gain	1.0000
15:92094876:TTCA:T	acceptor_loss	1.0000
15:92094878:CAGG:C	acceptor_loss	1.0000
15:92094879:A:AG	acceptor_gain	1.0000
15:92094879:AG:A	acceptor_gain	1.0000
15:92094880:G:A	acceptor_loss	1.0000
15:92094880:G:GA	acceptor_gain	1.0000
15:92094880:GG:G	acceptor_gain	1.0000
15:92094880:GGA:G	acceptor_gain	1.0000
15:92094977:CAA:C	donor_gain	1.0000
15:92094980:G:GG	donor_gain	1.0000
15:92094985:G:GT	donor_gain	1.0000
15:92120462:CAG:C	acceptor_loss	1.0000
15:92120463:A:AG	acceptor_gain	1.0000
15:92120463:A:T	acceptor_loss	1.0000
15:92120463:AGT:A	acceptor_gain	1.0000
15:92120464:G:GT	acceptor_gain	1.0000
15:92120464:GT:G	acceptor_gain	1.0000
15:92120464:GTG:G	acceptor_gain	1.0000
15:92120464:GTGA:G	acceptor_gain	1.0000
15:92120464:GTGAT:G	acceptor_gain	1.0000
15:92120574:G:GT	donor_gain	1.0000

AlphaMissense

4624 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:91916023:T:C	F71L	1.000
15:91916025:C:A	F71L	1.000
15:91916025:C:G	F71L	1.000
15:91916062:A:C	S84R	1.000
15:91916064:C:A	S84R	1.000
15:91916064:C:G	S84R	1.000
15:91916074:G:A	G88R	1.000
15:91916074:G:C	G88R	1.000
15:91916075:G:A	G88E	1.000
15:91916141:G:A	G110D	1.000
15:91916147:G:A	G112D	1.000
15:91916374:G:C	G188R	1.000
15:91916381:G:A	G190D	1.000
15:91916404:G:C	G198R	1.000
15:91916413:T:G	Y201D	1.000
15:92094908:G:A	G225E	1.000
15:92094919:G:T	G229W	1.000
15:92094920:G:A	G229E	1.000
15:92104313:G:C	W260C	1.000
15:92104313:G:T	W260C	1.000
15:92104318:G:A	G262E	1.000
15:92104323:T:A	W264R	1.000
15:92104323:T:C	W264R	1.000
15:92104326:T:A	W265R	1.000
15:92104326:T:C	W265R	1.000
15:92120566:T:C	F371L	1.000
15:92120568:T:A	F371L	1.000
15:92120568:T:G	F371L	1.000
15:92120593:T:C	F380L	1.000
15:92120595:T:A	F380L	1.000

dbSNP variants (sampled 300 via entrez): RS1000006392 (15:91870866 T>C), RS1000033908 (15:92042027 G>A), RS1000036727 (15:92057877 T>C), RS1000049856 (15:92169330 A>G), RS1000057911 (15:91931844 G>A,C), RS1000058031 (15:92028137 C>G), RS1000062393 (15:92063244 A>C), RS1000066020 (15:92070558 G>A), RS1000073082 (15:91911130 T>C), RS1000085068 (15:91879600 G>A), RS1000086887 (15:91917139 G>A), RS1000088237 (15:91942992 C>A), RS1000094553 (15:91859864 A>G), RS1000102326 (15:92134923 G>A), RS1000109294 (15:92052990 G>A,C)

Disease associations

OMIM: gene MIM:612435 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

19 associations (top):

Study	Trait	p-value
GCST000201_2	Response to iloperidone treatment (QT prolongation)	2.000000e-06
GCST000279_1	Inattentive symptoms	3.000000e-06
GCST001320_30	Acute lymphoblastic leukemia (childhood)	1.000000e-06
GCST001762_739	Obesity-related traits	8.000000e-06
GCST002058_7	DNA methylation (variation)	5.000000e-06
GCST002396_27	Smoking initiation	9.000000e-08
GCST002592_27	Neuritic plaque	5.000000e-06
GCST002593_46	Dementia and core Alzheimer’s disease neuropathologic changes	7.000000e-06
GCST003264_1075	Post bronchodilator FEV1/FVC ratio	4.000000e-06
GCST003264_951	Post bronchodilator FEV1/FVC ratio	5.000000e-06
GCST003631_4	Gastroesophageal reflux disease	2.000000e-07
GCST004030_27	Primary sclerosing cholangitis	2.000000e-06
GCST006630_70	Diastolic blood pressure	2.000000e-11
GCST008837_2	Estimated glomerular filtration rate reduction (30%)	3.000000e-06
GCST008837_3	Estimated glomerular filtration rate reduction (30%)	2.000000e-06
GCST008837_4	Estimated glomerular filtration rate reduction (30%)	2.000000e-06
GCST010002_104	Refractive error	6.000000e-12
GCST010988_26	Adult body size	3.000000e-09
GCST012366_1	Orofacial cleft x maternal periconceptional alcohol use interaction (1df)	4.000000e-07

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004810	interleukin-6 measurement
EFO:0022599	DNA methylation
EFO:0005670	smoking initiation
EFO:0006798	neuritic plaque measurement
EFO:0006801	Alzheimer’s disease neuropathologic change
EFO:0004713	FEV/FVC ratio
EFO:0006336	diastolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2073685 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

3 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1517618	SLCO3A1		0.00	0
rs4294800	SLCO3A1		0.00	0
rs8027174	SLCO3A1		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLCO family of organic anion transporting polypeptides

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	5
Tobacco Smoke Pollution	affects expression, decreases expression	4
Zoledronic Acid	decreases expression, increases expression	2
Aerosols	decreases expression	2
Estradiol	affects cotreatment, decreases expression	2
bufotalin	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
terbufos	decreases methylation	1
beta-lapachone	decreases expression	1
arsenite	increases methylation	1
mono-(2-ethylhexyl)phthalate	increases expression	1
sulforaphane	decreases expression	1
estrone sulfate	increases reaction, increases uptake	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
simvastatin acid	increases uptake, affects reaction, decreases expression, increases reaction	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
3-iodothyronamine	affects uptake	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
jinfukang	affects cotreatment, decreases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	affects methylation	1
Vehicle Emissions	decreases expression, decreases reaction	1
Benzo(a)pyrene	decreases expression	1

ChEMBL screening assays

9 unique, capped per target: 9 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2075191	Functional	TP_TRANSPORTER: uptake in Xenopus laevis oocytes	Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. — Exp Eye Res

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4WH	LS180-SLCO3A1-KO-c7	Cancer cell line	Female
CVCL_D4WI	LS180-SLCO3A1-KO-c9	Cancer cell line	Female
CVCL_TP37	HAP1 SLCO3A1 (-) 1	Cancer cell line	Male
CVCL_XT44	HAP1 SLCO3A1 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.