SLCO4A1-AS1

Summary

SLCO4A1-AS1 (SLCO4A1 antisense RNA 1, HGNC:40537) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40537
Approved symbol	SLCO4A1-AS1
Name	SLCO4A1 antisense RNA 1
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	DAMER
Ensembl gene	ENSG00000232803
Ensembl biotype	lncRNA
Entrez	100127888
RNAcentral	URS000075A1F5 — lncRNA, 1440 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000411824, ENST00000433126, ENST00000451648

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411824 — 2 exons

Exon	Start	End
ENSE00001656512	62663019	62663487
ENSE00001729032	62666385	62666724

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 90.28.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7028 / max 245.5926, expressed in 64 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188288	0.5127	44
188289	0.1177	29
188291	0.0353	6
188287	0.0153	10
188292	0.0083	3
188286	0.0075	4
188290	0.0033	2
188293	0.0028	2

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	90.28	gold quality
skin of leg	UBERON:0001511	81.67	gold quality
saliva-secreting gland	UBERON:0001044	80.05	gold quality
skin of abdomen	UBERON:0001416	79.47	gold quality
minor salivary gland	UBERON:0001830	78.03	gold quality
zone of skin	UBERON:0000014	76.99	gold quality
right lung	UBERON:0002167	74.17	gold quality
metanephros cortex	UBERON:0010533	74.08	gold quality
mouth mucosa	UBERON:0003729	73.66	gold quality
lower esophagus mucosa	UBERON:0035834	72.83	gold quality
bone marrow cell	CL:0002092	72.81	gold quality
gastrocnemius	UBERON:0001388	72.10	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.43	gold quality
upper lobe of left lung	UBERON:0008952	70.95	gold quality
muscle of leg	UBERON:0001383	70.53	gold quality
gall bladder	UBERON:0002110	69.11	gold quality
tibial nerve	UBERON:0001323	68.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.45	gold quality
upper lobe of lung	UBERON:0008948	68.27	gold quality
omental fat pad	UBERON:0010414	68.18	gold quality
peritoneum	UBERON:0002358	68.11	gold quality
apex of heart	UBERON:0002098	68.07	gold quality
mucosa of stomach	UBERON:0001199	67.82	gold quality
heart left ventricle	UBERON:0002084	67.65	gold quality
ectocervix	UBERON:0012249	67.26	gold quality
buccal mucosa cell	CL:0002336	66.84	silver quality
small intestine Peyer’s patch	UBERON:0003454	66.83	gold quality
cardiac ventricle	UBERON:0002082	66.73	gold quality
adipose tissue of abdominal region	UBERON:0007808	66.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• SLCO4A1-AS1 serves as an oncogenic role in CRC through activating Wnt/beta-catenin signaling pathway. And SLCO4A1-AS1 might be a useful biomarker for colorectal cancer (CRC) diagnosis and prognosis. (PMID:30201010)
• The current study demonstrates that the SLCO4A1-AS1/miR-508-3p/PARD3/autophagy pathway play a critical role in colorectal cancer cell proliferation (PMID:31308265)
• Long non-coding RNA SLCO4A1-AS1 drives the progression of non-small-cell lung cancer by modulating miR-223-3p/IKKalpha/NF-kappaB signaling. (PMID:32687454)
• The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway. (PMID:33683013)
• SLCO4A1-AS1 regulates laryngeal squamous cell carcinoma cell phenotypes via the Wnt pathway. (PMID:33914996)
• LncRNA SLCO4A1-AS1 modulates colon cancer stem cell properties by binding to miR-150-3p and positively regulating SLCO4A1. (PMID:33958701)
• SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling. (PMID:35039060)
• SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via sponging miR-1306-5p to enhance PCGF2. (PMID:35427425)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.