SLCO5A1

Summary

SLCO5A1 (solute carrier organic anion transporter family member 5A1, HGNC:19046) is a protein-coding gene on chromosome 8q13.3, encoding Solute carrier organic anion transporter family member 5A1 (Q9H2Y9).

Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in intracellular membrane-bounded organelle and plasma membrane.

Source: NCBI Gene 81796 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 398 total
• MANE Select transcript: NM_030958

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19046
Approved symbol	SLCO5A1
Name	solute carrier organic anion transporter family member 5A1
Location	8q13.3
Locus type	gene with protein product
Status	Approved
Aliases	OATPRP4, OATP-J, OATP5A1
Ensembl gene	ENSG00000137571
Ensembl biotype	protein_coding
OMIM	613543
Entrez	81796

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 8 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000260126, ENST00000524703, ENST00000524945, ENST00000526750, ENST00000528658, ENST00000530307, ENST00000531422, ENST00000532388, ENST00000925716, ENST00000925717, ENST00000958411, ENST00000958412, ENST00000958413

RefSeq mRNA: 3 — MANE Select: NM_030958 NM_001146008, NM_001146009, NM_030958

CCDS: CCDS55242, CCDS55243, CCDS6205

Canonical transcript exons

ENST00000260126 — 10 exons

Exon	Start	End
ENSE00000928486	69705031	69705229
ENSE00000928487	69738040	69738204
ENSE00002185266	69834854	69834978
ENSE00002604169	69667046	69673326
ENSE00003491283	69755424	69755641
ENSE00003525876	69831767	69833169
ENSE00003541217	69676609	69676673
ENSE00003635133	69761743	69761875
ENSE00003654509	69682184	69682343
ENSE00003679135	69679378	69679619

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 94.83.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2395 / max 162.0233, expressed in 361 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93482	0.6718	237
93481	0.4356	148
93479	0.0691	20
93478	0.0285	14
93477	0.0208	6
93480	0.0137	5

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.83	gold quality
biceps brachii	UBERON:0001507	94.02	gold quality
heart right ventricle	UBERON:0002080	93.52	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.30	gold quality
body of tongue	UBERON:0011876	84.50	gold quality
cortical plate	UBERON:0005343	82.97	gold quality
ganglionic eminence	UBERON:0004023	82.25	gold quality
skeletal muscle tissue	UBERON:0001134	80.41	gold quality
deltoid	UBERON:0001476	79.03	silver quality
hindlimb stylopod muscle	UBERON:0004252	78.57	gold quality
vastus lateralis	UBERON:0001379	78.52	gold quality
quadriceps femoris	UBERON:0001377	77.29	gold quality
muscle organ	UBERON:0001630	77.17	gold quality
gastrocnemius	UBERON:0001388	76.97	gold quality
muscle of leg	UBERON:0001383	76.16	gold quality
muscle tissue	UBERON:0002385	75.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.09	gold quality
buccal mucosa cell	CL:0002336	74.72	gold quality
endothelial cell	CL:0000115	74.55	gold quality
tongue	UBERON:0001723	73.33	gold quality
cardiac ventricle	UBERON:0002082	72.85	gold quality
heart left ventricle	UBERON:0002084	72.57	gold quality
apex of heart	UBERON:0002098	72.21	gold quality
tibialis anterior	UBERON:0001385	71.25	silver quality
ventricular zone	UBERON:0003053	71.18	gold quality
myocardium	UBERON:0002349	71.07	silver quality
islet of Langerhans	UBERON:0000006	69.68	gold quality
left ventricle myocardium	UBERON:0006566	69.64	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.63	gold quality
epithelium of nasopharynx	UBERON:0001951	69.61	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7381	yes	522.32
E-HCAD-5	yes	28.16
E-ANND-3	no	6.08

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

85 targeting SLCO5A1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488

Literature-anchored findings (GeneRIF, showing 5)

• Haploinsufficiency of SULF1 combined with haploinsufficiency of SLCO5A1 (or the altered expression of a neighboring gene through position effect) could be necessary in the pathogenesis of MSS. (PMID:20602915)
• tissue-specific localization of OATP2B1, OATP3A1 and OATP5A1 has been analyzed in normal mammary tissue and corresponding breast cancer tissues. (PMID:21278488)
• SLCO5A1 is an organic anion transporting polypeptide which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. (PMID:24376674)
• High OATP5A1 expression is associated with small cell lung cancer. (PMID:25301452)
• Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans. (PMID:33619025)

Cross-species orthologs

13 orthologs

Organism	Symbol	Gene ID
danio_rerio	slco5a1a	ENSDARG00000071685
mus_musculus	Slco5a1	ENSMUSG00000025938
rattus_norvegicus	Slco5a1	ENSRNOG00000008966
drosophila_melanogaster	Oatp33Ea	FBGN0032433
drosophila_melanogaster	Oatp33Eb	FBGN0032435
drosophila_melanogaster	Oatp58Db	FBGN0034715
drosophila_melanogaster	Oatp58Dc	FBGN0034716
drosophila_melanogaster	Oatp74D	FBGN0036732
drosophila_melanogaster	Oatp58Da	FBGN0050277
caenorhabditis_elegans		WBGENE00009023
caenorhabditis_elegans		WBGENE00012531
caenorhabditis_elegans		WBGENE00018566
caenorhabditis_elegans		WBGENE00018568

Paralogs (10): SLCO1A2 (ENSG00000084453), SLCO4A1 (ENSG00000101187), SLCO1B3 (ENSG00000111700), SLCO1B1 (ENSG00000134538), SLCO2B1 (ENSG00000137491), SLCO1C1 (ENSG00000139155), SLCO4C1 (ENSG00000173930), SLCO2A1 (ENSG00000174640), SLCO3A1 (ENSG00000176463), SLCO6A1 (ENSG00000205359)

Protein

Protein identifiers

Solute carrier organic anion transporter family member 5A1 — Q9H2Y9 (reviewed: Q9H2Y9)

Alternative names: Organic anion transporter polypeptide-related protein 4, Solute carrier family 21 member 15

All UniProt accessions (2): Q9H2Y9, E9PPI0

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cell membrane.

Similarity. Belongs to the organo anion transporter (TC 2.A.60) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9H2Y9-1	1	yes
Q9H2Y9-2	2
Q9H2Y9-3	3

RefSeq proteins (3): NP_001139480, NP_001139481, NP_112220* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002350	Kazal_dom	Domain
IPR004156	OATP	Family
IPR020846	MFS_dom	Domain
IPR036058	Kazal_dom_sf	Homologous_superfamily
IPR036259	MFS_trans_sf	Homologous_superfamily

Pfam: PF03137, PF07648

UniProt features (48 total): topological domain 13, transmembrane region 12, glycosylation site 7, disulfide bond 3, splice variant 3, sequence conflict 3, region of interest 2, compositionally biased region 2, chain 1, domain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H2Y9-F1	70.91	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (3): 555–585, 561–581, 570–601

Glycosylation sites (7): 228, 241, 469, 550, 590, 597, 730

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 171 (showing top): GOBP_SODIUM_INDEPENDENT_ORGANIC_ANION_TRANSPORT, BENPORATH_ES_WITH_H3K27ME3, WWTAAGGC_UNKNOWN, HNF1_Q6, CTATGCA_MIR153, GTGCCTT_MIR506, NKX62_Q2, GOBP_ORGANIC_ANION_TRANSPORT, TGANTCA_AP1_C, NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON, DODD_NASOPHARYNGEAL_CARCINOMA_UP, LEF1_Q6, GATA4_Q3, CERVERA_SDHB_TARGETS_1_UP, RIGGI_EWING_SARCOMA_PROGENITOR_UP

GO Biological Process (2): sodium-independent organic anion transport (GO:0043252), transmembrane transport (GO:0055085)

GO Molecular Function (3): obsolete sodium-independent organic anion transmembrane transporter activity (GO:0015347), protein binding (GO:0005515), transmembrane transporter activity (GO:0022857)

GO Cellular Component (3): plasma membrane (GO:0005886), basolateral plasma membrane (GO:0016323), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane transport	2
transport	1
cellular process	1
binding	1
transporter activity	1
membrane	1
cell periphery	1
basal plasma membrane	1
plasma membrane region	1
cellular anatomical structure	1

Protein interactions and networks

STRING

630 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLCO5A1	SULF1	Q8IWU6	925
SLCO5A1	SULF2	Q8IWU5	497
SLCO5A1	RLIG1	Q8N999	478
SLCO5A1	RNF217	Q8TC41	453
SLCO5A1	SLCO3A1	Q9UIG8	429
SLCO5A1	SHOX	O15266	427
SLCO5A1	RAB31	Q13636	406
SLCO5A1	SLC22A14	Q9Y267	389
SLCO5A1	G0S2	P27469	380
SLCO5A1	VAC14	Q08AM6	377
SLCO5A1	XKR9	Q5GH70	370
SLCO5A1	CCDC166	P0CW27	365
SLCO5A1	SLC22A10	Q63ZE4	359
SLCO5A1	WNT11	O96014	353
SLCO5A1	RAB20	Q9NX57	349

IntAct

4 interactions, top by confidence:

A	B	Type	Score
SLCO5A1	HNRNPK	psi-mi:“MI:0915”(physical association)	0.400
SLCO5A1	CAND2	psi-mi:“MI:0914”(association)	0.350
dinG	SLCO5A1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): SLCO5A1 (Affinity Capture-RNA), SLCO5A1 (Proximity Label-MS), SLCO5A1 (Cross-Linking-MS (XL-MS)), UGGT1 (Co-fractionation), SLCO5A1 (Co-fractionation), SLCO5A1 (Co-fractionation), SLCO5A1 (Co-fractionation), SLCO5A1 (Co-fractionation), SLCO5A1 (Co-fractionation), CAND2 (Affinity Capture-MS), GOLPH3 (Affinity Capture-MS), GOLPH3L (Affinity Capture-MS), MICU1 (Affinity Capture-MS), SLC16A13 (Affinity Capture-MS), SLCO6A1 (Affinity Capture-MS)

ESM2 similar proteins: A2A259, A2AIR5, H2Q5A1, O00222, O15399, O60242, O75077, O75882, O97741, P15209, P24786, P31423, P35400, P37088, P47743, P55270, P70579, Q00961, Q01098, Q03351, Q03391, Q13507, Q14833, Q14957, Q16288, Q1ZZH0, Q4R766, Q5IS37, Q5RDQ8, Q62645, Q63604, Q68ED2, Q68EF4, Q6AYT7, Q80ZF8, Q8CIW5, Q8TCU5, Q8VHN2, Q91044, Q91YD4

Diamond homologs: F5H094, G3V0H7, O35913, O88397, O94956, P46720, P46721, P70502, Q00910, Q5RFF0, Q6ZQN7, Q71MB6, Q8BGD4, Q8BXB6, Q8HYW2, Q8R3L5, Q91YY5, Q92959, Q96BD0, Q99J94, Q99N01, Q99N02, Q9EP96, Q9EPT5, Q9EPZ7, Q9ERB5, Q9GMU6, Q9H2Y9, Q9JHI3, Q9JJL3, Q9NPD5, Q9NYB5, Q9QXZ6, Q9QYE2, Q9QZX8, Q9UIG8, Q9Y6L6, Q8K078, A2ASQ1, D0NJ41

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

398 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	254
Likely benign	106
Benign	24

Top pathogenic / likely-pathogenic (0)

SpliceAI

3193 predictions. Top by Δscore:

Variant	Effect	Δscore
8:69679013:T:TA	donor_gain	1.0000
8:69755418:CTTTA:C	donor_loss	1.0000
8:69755419:TTTAC:T	donor_loss	1.0000
8:69755420:TTAC:T	donor_loss	1.0000
8:69755421:TAC:T	donor_loss	1.0000
8:69755422:ACC:A	donor_loss	1.0000
8:69755423:C:G	donor_loss	1.0000
8:69755423:CCT:C	donor_gain	1.0000
8:69761876:C:CC	acceptor_gain	1.0000
8:69831761:TCTTA:T	donor_loss	1.0000
8:69831762:CTTAC:C	donor_loss	1.0000
8:69831763:TTAC:T	donor_loss	1.0000
8:69831764:TAC:T	donor_loss	1.0000
8:69831765:A:C	donor_loss	1.0000
8:69678627:C:A	donor_gain	0.9900
8:69705227:CCC:C	acceptor_gain	0.9900
8:69705228:CCC:C	acceptor_gain	0.9900
8:69705974:C:CT	acceptor_gain	0.9900
8:69738205:C:CC	acceptor_gain	0.9900
8:69755432:T:TA	donor_gain	0.9900
8:69761741:A:AC	donor_gain	0.9900
8:69761742:C:CC	donor_gain	0.9900
8:69761873:TGG:T	acceptor_gain	0.9900
8:69833168:ACCT:A	acceptor_loss	0.9900
8:69833170:C:CC	acceptor_gain	0.9900
8:69834852:A:AC	donor_gain	0.9900
8:69834853:C:CC	donor_gain	0.9900
8:69834853:CTAG:C	donor_gain	0.9900
8:69834909:TGAGC:T	donor_gain	0.9900
8:69682344:C:CC	acceptor_gain	0.9800

AlphaMissense

5528 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:69673230:T:C	Y729C	1.000
8:69673238:G:C	C726W	1.000
8:69673239:C:G	C726S	1.000
8:69673239:C:T	C726Y	1.000
8:69673240:A:G	C726R	1.000
8:69673240:A:T	C726S	1.000
8:69673268:C:A	W716C	1.000
8:69673268:C:G	W716C	1.000
8:69673277:G:C	C713W	1.000
8:69673278:C:A	C713F	1.000
8:69673278:C:G	C713S	1.000
8:69673278:C:T	C713Y	1.000
8:69673279:A:G	C713R	1.000
8:69673279:A:T	C713S	1.000
8:69673287:T:A	D710V	1.000
8:69673288:C:G	D710H	1.000
8:69673299:C:A	G706V	1.000
8:69673299:C:T	G706E	1.000
8:69673300:C:G	G706R	1.000
8:69673300:C:T	G706R	1.000
8:69673317:G:T	P700H	1.000
8:69679438:A:G	L655P	1.000
8:69679480:C:G	C641S	1.000
8:69679481:A:T	C641S	1.000
8:69679595:A:G	C603R	1.000
8:69679599:G:C	C601W	1.000
8:69679600:C:G	C601S	1.000
8:69679601:A:G	C601R	1.000
8:69679601:A:T	C601S	1.000
8:69682211:A:C	C585W	1.000

dbSNP variants (sampled 300 via entrez): RS1000001104 (8:69775398 G>A,T), RS1000008593 (8:69690884 A>C), RS1000011643 (8:69733336 T>C,G), RS1000012940 (8:69676311 C>T), RS1000038390 (8:69771526 G>A), RS1000062485 (8:69811137 TG>T), RS1000065818 (8:69739433 A>G), RS1000110199 (8:69771176 G>C,T), RS1000152808 (8:69822757 G>A), RS1000160053 (8:69797254 T>C,G), RS1000165778 (8:69800199 G>A), RS1000183531 (8:69676985 AT>A,ATT), RS1000193643 (8:69805023 T>A), RS1000194509 (8:69712125 G>T), RS1000201957 (8:69715323 C>A,T)

Disease associations

OMIM: gene MIM:613543 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST002119_12	Metabolite levels (X-11787)	2.000000e-06
GCST004833_5	Cervical cancer	7.000000e-06
GCST006479_48	Diverticular disease	5.000000e-06
GCST009207_9	Lateral ventricle volume	7.000000e-07
GCST009698_101	Metabolite levels	2.000000e-09
GCST90002379_121	Basophil count	1.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005276	hydroxy-leucine measurement
EFO:0009959	diverticular disease
EFO:0008487	lateral ventricle volume measurement
EFO:0005090	basophil count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — SLCO family of organic anion transporting polypeptides

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Nickel	increases expression	2
methylmercuric chloride	increases expression	1
benzo(e)pyrene	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	increases expression, affects cotreatment, affects response to substance	1
CGP 52608	affects binding, increases reaction	1
pinostrobin	increases expression	1
3-iodothyronamine	affects uptake	1
abrine	increases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acetaminophen	increases expression	1
Amiodarone	increases expression	1
Arbutin	decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Lipopolysaccharides	increases expression, affects response to substance, affects cotreatment	1
Methapyrilene	increases methylation	1
Methyl Methanesulfonate	decreases expression	1
Niclosamide	increases expression	1
Quercetin	increases uptake	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Xylitol	increases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	increases expression	1

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D4WJ	LS180-SLCO5A1-KO-c2	Cancer cell line	Female
CVCL_D4WK	LS180-SLCO5A1-KO-c9	Cancer cell line	Female
CVCL_TP39	HAP1 SLCO5A1 (-) 1	Cancer cell line	Male
CVCL_XT47	HAP1 SLCO5A1 (-) 2	Cancer cell line	Male
CVCL_XT48	HAP1 SLCO5A1 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.