SLEAR

Summary

SLEAR (STAT1 regulated ILF2 complex interacting lncRNA, HGNC:54824) is a long non-coding RNA gene on chromosome 8q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54824
Approved symbol	SLEAR
Name	STAT1 regulated ILF2 complex interacting lncRNA
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ42969
Ensembl gene	ENSG00000248599
Ensembl biotype	lncRNA
Entrez	441374
RNAcentral	URS000022C200 — lncRNA, 1948 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000514926, ENST00000653963, ENST00000653983, ENST00000655682, ENST00000656334, ENST00000656569, ENST00000657076, ENST00000658504, ENST00000660508, ENST00000662046, ENST00000665441, ENST00000665627, ENST00000666510, ENST00000669613

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000514926 — 3 exons

Exon	Start	End
ENSE00002027446	101052015	101052836
ENSE00002063679	101075169	101076252
ENSE00002071295	101054498	101054579

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 92.25.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0794 / max 24.2728, expressed in 35 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90008	0.0596	29
90006	0.0152	3
90007	0.0047	1

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.25	gold quality
heart left ventricle	UBERON:0002084	61.72	gold quality
right adrenal gland cortex	UBERON:0035827	61.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.22	gold quality
right adrenal gland	UBERON:0001233	60.27	gold quality
heart	UBERON:0000948	57.42	gold quality
adrenal gland	UBERON:0002369	57.30	gold quality
left adrenal gland	UBERON:0001234	57.14	gold quality
left adrenal gland cortex	UBERON:0035825	56.84	gold quality
prefrontal cortex	UBERON:0000451	55.86	gold quality
cortical plate	UBERON:0005343	55.57	silver quality
placenta	UBERON:0001987	54.97	gold quality
superior frontal gyrus	UBERON:0002661	53.47	gold quality
adrenal tissue	UBERON:0018303	53.04	gold quality
islet of Langerhans	UBERON:0000006	52.43	gold quality
left ovary	UBERON:0002119	52.41	gold quality
frontal cortex	UBERON:0001870	52.37	gold quality
hypothalamus	UBERON:0001898	52.16	gold quality
urinary bladder	UBERON:0001255	52.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	51.01	gold quality
lymph node	UBERON:0000029	50.89	gold quality
monocyte	CL:0000576	50.87	silver quality
right atrium auricular region	UBERON:0006631	50.51	gold quality
gall bladder	UBERON:0002110	50.29	gold quality
saliva-secreting gland	UBERON:0001044	50.26	gold quality
cerebral cortex	UBERON:0000956	50.23	gold quality
anterior cingulate cortex	UBERON:0009835	50.10	gold quality
blood	UBERON:0000178	50.09	gold quality
tonsil	UBERON:0002372	49.84	gold quality
minor salivary gland	UBERON:0001830	49.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus. (PMID:31930717)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.