SLF1

Summary

SLF1 (SMC5/6 complex localization factor 1, HGNC:25408) is a protein-coding gene on chromosome 5q15, encoding SMC5-SMC6 complex localization factor protein 1 (Q9BQI6). Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance.

Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break.

Source: NCBI Gene 84250 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 171 total
• MANE Select transcript: NM_032290

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25408
Approved symbol	SLF1
Name	SMC5/6 complex localization factor 1
Location	5q15
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp761C121, DKFZp564C0469, BRCTx, hNSE5
Ensembl gene	ENSG00000133302
Ensembl biotype	protein_coding
OMIM	618467
Entrez	84250

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 9 protein_coding, 2 retained_intron, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined

ENST00000265140, ENST00000450932, ENST00000466957, ENST00000475916, ENST00000493934, ENST00000504099, ENST00000508130, ENST00000508383, ENST00000908676, ENST00000939302, ENST00000939303, ENST00000939304, ENST00000939305, ENST00000966409, ENST00000966410

RefSeq mRNA: 1 — MANE Select: NM_032290 NM_032290

CCDS: CCDS4071

Canonical transcript exons

ENST00000265140 — 21 exons

Exon	Start	End
ENSE00001837084	94694831	94697621
ENSE00001844062	94618669	94618765
ENSE00002203241	94654630	94654752
ENSE00002205179	94670843	94671008
ENSE00002227255	94630503	94630743
ENSE00002233772	94670151	94670279
ENSE00002251960	94665861	94666024
ENSE00002273771	94678808	94678955
ENSE00002286007	94643273	94643435
ENSE00003459924	94628811	94628924
ENSE00003461409	94662298	94662351
ENSE00003489970	94651702	94651845
ENSE00003494205	94689473	94689606
ENSE00003541636	94686573	94686718
ENSE00003560946	94688506	94688669
ENSE00003572971	94653272	94653421
ENSE00003576048	94663750	94663908
ENSE00003585622	94649454	94649597
ENSE00003613552	94629092	94629167
ENSE00003646180	94692074	94692256
ENSE00003676097	94691564	94691656

Expression profiles

Bgee: expression breadth ubiquitous, 232 present calls, max score 95.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.8117 / max 488.0229, expressed in 1599 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57605	11.0319	1588
57608	1.1382	145
57606	0.5166	275
57610	0.1051	34
57609	0.0199	7

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	95.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.90	gold quality
oocyte	CL:0000023	92.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.14	gold quality
middle temporal gyrus	UBERON:0002771	87.41	gold quality
ventricular zone	UBERON:0003053	87.23	gold quality
Brodmann (1909) area 46	UBERON:0006483	86.92	gold quality
cerebellar hemisphere	UBERON:0002245	85.39	gold quality
cerebellar cortex	UBERON:0002129	85.32	gold quality
calcaneal tendon	UBERON:0003701	85.20	gold quality
cerebellum	UBERON:0002037	85.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.82	gold quality
ganglionic eminence	UBERON:0004023	84.81	gold quality
embryo	UBERON:0000922	84.80	gold quality
cortical plate	UBERON:0005343	84.11	gold quality
testis	UBERON:0000473	82.57	gold quality
cerebellar vermis	UBERON:0004720	82.45	gold quality
right testis	UBERON:0004534	81.82	gold quality
bone marrow	UBERON:0002371	81.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.53	gold quality
bronchial epithelial cell	CL:0002328	81.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.32	gold quality
left testis	UBERON:0004533	81.13	gold quality
bone marrow cell	CL:0002092	80.98	gold quality
right frontal lobe	UBERON:0002810	80.92	gold quality
sural nerve	UBERON:0015488	80.86	gold quality
granulocyte	CL:0000094	80.29	gold quality
bronchus	UBERON:0002185	80.23	gold quality
superior frontal gyrus	UBERON:0002661	79.91	gold quality
frontal cortex	UBERON:0001870	79.76	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-8894	yes	461.87
E-ANND-3	yes	4.88
E-GEOD-109979	no	203.73

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

38 targeting SLF1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-4666A-5P	99.41	69.72	1887
HSA-MIR-4263	99.18	69.25	2236
HSA-MIR-1253	99.12	67.08	1688
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-455-3P	98.94	67.68	878
HSA-MIR-4724-5P	98.87	67.75	1324
HSA-MIR-3149	98.77	67.13	1639
HSA-MIR-6773-3P	98.17	65.51	1213
HSA-MIR-4659B-5P	98.03	66.84	979
HSA-MIR-4659A-5P	98.03	66.42	819
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-4700-3P	97.74	68.64	1014
HSA-MIR-4308	97.56	67.13	1385
HSA-MIR-937-5P	97.43	68.39	667
HSA-MIR-215-3P	97.02	68.01	1209
HSA-MIR-3674	97.01	68.86	1171

Literature-anchored findings (GeneRIF, showing 1)

• Results describe the cloning, characterization, and targeted mutagenesis of Brctx, a novel gene with a BRCT motif [Brctx]. (PMID:15632077)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	slf1	ENSDARG00000102118
mus_musculus	Slf1	ENSMUSG00000021597
rattus_norvegicus	Slf1	ENSRNOG00000040279

Paralogs (1): TOPBP1 (ENSG00000163781)

Protein

Protein identifiers

SMC5-SMC6 complex localization factor protein 1 — Q9BQI6 (reviewed: Q9BQI6)

Alternative names: Ankyrin repeat domain-containing protein 32, BRCT domain-containing protein 1, Smc5/6 localization factor 1

All UniProt accessions (3): D6RED9, Q9BQI6, H0YBU1

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.

Subunit / interactions. Interacts (via N-terminus) with SLF2; this interaction links RAD18 to the SMC5-SMC6 complex. Interacts (via BRCT domains) with RAD18; this interaction occurs in a SLF2-independent manner. Interacts with SMC6. Interacts (via BRCT domains) with RAD18 (via C-terminus and phosphorylated form); this interaction is required for efficient repair of UV-induced DNA damage.

Subcellular location. Nucleus. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome.

Domain organisation. BRCT domains are necessary for its targeting to ionizing radiation-induced nuclear foci.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BQI6-1	1	yes
Q9BQI6-2	2

RefSeq proteins (1): NP_115666* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001357	BRCT_dom	Domain
IPR002110	Ankyrin_rpt	Repeat
IPR036420	BRCT_dom_sf	Homologous_superfamily
IPR036770	Ankyrin_rpt-contain_sf	Homologous_superfamily
IPR042479	Slf1	Family
IPR049935	BRCT_SLF1	Domain
IPR057595	TopB1_SLF1_BRCT	Domain

Pfam: PF12796, PF16770, PF23294

UniProt features (42 total): helix 18, strand 7, sequence conflict 5, repeat 3, domain 2, splice variant 2, chain 1, sequence variant 1, turn 1, region of interest 1, cross-link 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
8PEF	X-RAY DIFFRACTION	1.28
8IR4	X-RAY DIFFRACTION	1.62
8IR2	X-RAY DIFFRACTION	1.75

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BQI6-F1	69.35	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 931

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 183 (showing top): GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, GOBP_CHROMOSOME_ORGANIZATION, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_TELOMERE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_REGULATION_OF_DNA_REPAIR, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_REGULATION_OF_TELOMERE_MAINTENANCE, GOBP_PEPTIDYL_LYSINE_MODIFICATION, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, GOBP_SISTER_CHROMATID_COHESION, GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME, GOBP_REGULATION_OF_CELL_CYCLE

GO Biological Process (10): double-strand break repair via homologous recombination (GO:0000724), DNA damage response (GO:0006974), protein sumoylation (GO:0016925), positive regulation of protein-containing complex assembly (GO:0031334), regulation of telomere maintenance (GO:0032204), positive regulation of maintenance of mitotic sister chromatid cohesion (GO:0034184), chromatin looping (GO:0140588), protein localization to site of double-strand break (GO:1990166), positive regulation of double-strand break repair (GO:2000781), DNA repair (GO:0006281)

GO Molecular Function (3): ubiquitin protein ligase binding (GO:0031625), protein-containing complex binding (GO:0044877), protein binding (GO:0005515)

GO Cellular Component (11): chromosome, telomeric region (GO:0000781), nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), centrosome (GO:0005813), Smc5-Smc6 complex (GO:0030915), site of double-strand break (GO:0035861), nuclear inclusion body (GO:0042405), chromosome (GO:0005694), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
double-strand break repair	2
binding	2
cellular anatomical structure	2
intracellular membraneless organelle	2
recombinational repair	1
cellular response to stress	1
peptidyl-lysine modification	1
protein modification by small protein conjugation	1
regulation of protein-containing complex assembly	1
positive regulation of cellular component biogenesis	1
positive regulation of cellular component organization	1
protein-containing complex assembly	1
telomere maintenance	1
regulation of chromosome organization	1
regulation of DNA metabolic process	1
maintenance of mitotic sister chromatid cohesion	1
positive regulation of maintenance of sister chromatid cohesion	1
regulation of maintenance of mitotic sister chromatid cohesion	1
chromatin organization	1
protein localization to chromosome	1
positive regulation of DNA repair	1
regulation of double-strand break repair	1
DNA metabolic process	1
DNA damage response	1
ubiquitin-like protein ligase binding	1
chromosomal region	1
chromatin	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
condensed chromosome	1
SUMO ligase complex	1
site of DNA damage	1
nucleus	1
inclusion body	1

Protein interactions and networks

STRING

2925 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SLF1	SLF2	Q8IX21	987
SLF1	RAD18	Q9NS91	784
SLF1	SMC5	Q8IY18	772
SLF1	NSMCE1	Q8WV22	593
SLF1	ARB2A	Q8WUF8	572
SLF1	RNF168	Q8IYW5	571
SLF1	TP53BP1	Q12888	530
SLF1	PAXIP1	Q6ZW49	525
SLF1	MCTP1	Q6DN14	524
SLF1	RNF169	Q8NCN4	515
SLF1	NSMCE2	Q96MF7	507
SLF1	SMC6	Q96SB8	498
SLF1	MDC1	Q14676	493
SLF1	NSMCE3	Q96MG7	465
SLF1	HLTF	Q14527	460

IntAct

25 interactions, top by confidence:

A	B	Type	Score
SLF2	SLF1	psi-mi:“MI:0915”(physical association)	0.780
SLF1	SLF2	psi-mi:“MI:0914”(association)	0.780
NFKB1	NFKBIE	psi-mi:“MI:2364”(proximity)	0.600
MAGEA10	POTEF	psi-mi:“MI:0914”(association)	0.530
SLF1	PDIA6	psi-mi:“MI:0915”(physical association)	0.400
UBTF	SLF1	psi-mi:“MI:0915”(physical association)	0.400
PARD6B	PARD3	psi-mi:“MI:0914”(association)	0.350
SMC6	IFT88	psi-mi:“MI:0914”(association)	0.350
SLF2	GCFC2	psi-mi:“MI:0914”(association)	0.350
RAD18	SRGAP3	psi-mi:“MI:0914”(association)	0.350
NFKB1	NFKB1	psi-mi:“MI:0914”(association)	0.350
RAD18	H2AC4	psi-mi:“MI:0914”(association)	0.350
PIPSL	C1orf226	psi-mi:“MI:0914”(association)	0.350
FTL	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350
SLF1	CD8A	psi-mi:“MI:0914”(association)	0.350
FTL		psi-mi:“MI:0914”(association)	0.350
MAGEA10	KANSL1L	psi-mi:“MI:0914”(association)	0.350
BRCA1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (36): ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Two-hybrid), ANKRD32 (Affinity Capture-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Proximity Label-MS), ANKRD32 (Affinity Capture-MS), ANKRD32 (Proximity Label-MS), ANKRD32 (Proximity Label-MS), ANKRD32 (Negative Genetic)

ESM2 similar proteins: A0A0A6YYL3, A0JP26, A2A2Z9, A2RUR9, A6NC57, A6NI47, A6QR20, A8MYB1, A9JSR5, A9ZSY0, B2RU33, B7ZQJ9, F1M5M3, H3BUK9, O15050, P51954, P98182, Q19UN5, Q4UJ75, Q501X2, Q5CZ79, Q5DW34, Q5SQ80, Q5TYW2, Q5VUR7, Q66HB6, Q6NSI1, Q6S545, Q6S5H5, Q6S8J7, Q71S21, Q7TPV2, Q7TSC3, Q7ZT11, Q80X59, Q811D2, Q86Y13, Q86YR6, Q8IVF6, Q8IYA2

Diamond homologs: A2AQH4, A2AS55, A6NGH8, A6QR20, O14974, Q2T9W8, Q499M5, Q5H9F3, Q641X1, Q6P6B7, Q6W2J9, Q86WC6, Q8CGN4, Q9BQI6, Q9D119, Q9UU77, Q9XZC0, A4II29, A5WVX9, B4E2M5, D3Z7P3, E9PTT0, G5EGA3, O83515, O94925, P13264, Q01317, Q15653, Q21920, Q3SX45, Q3U0L2, Q4FE45, Q4JHE0, Q502K3, Q54HW1, Q5U5A6, Q6NSI1, Q6NY19, Q7T3Y0, Q7Z6K4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

171 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	142
Likely benign	13
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

4478 predictions. Top by Δscore:

Variant	Effect	Δscore
5:94628795:T:G	acceptor_gain	1.0000
5:94628799:T:TA	acceptor_gain	1.0000
5:94628802:A:AG	acceptor_gain	1.0000
5:94628802:ATTT:A	acceptor_gain	1.0000
5:94628803:T:G	acceptor_gain	1.0000
5:94628805:T:TA	acceptor_gain	1.0000
5:94628806:GTTAG:G	acceptor_loss	1.0000
5:94628807:TTAGA:T	acceptor_loss	1.0000
5:94628808:TAGAT:T	acceptor_loss	1.0000
5:94628809:A:AG	acceptor_gain	1.0000
5:94628809:A:T	acceptor_loss	1.0000
5:94628810:G:GA	acceptor_gain	1.0000
5:94628871:G:GT	donor_gain	1.0000
5:94628920:GTGAG:G	donor_gain	1.0000
5:94628921:TGAGG:T	donor_loss	1.0000
5:94628922:GAGGT:G	donor_loss	1.0000
5:94628923:AGGTA:A	donor_loss	1.0000
5:94628924:GGTA:G	donor_loss	1.0000
5:94628925:G:GC	donor_loss	1.0000
5:94628926:T:G	donor_loss	1.0000
5:94629090:A:AG	acceptor_gain	1.0000
5:94629091:G:GG	acceptor_gain	1.0000
5:94630499:CTAGG:C	acceptor_loss	1.0000
5:94630500:TA:T	acceptor_loss	1.0000
5:94630501:A:C	acceptor_loss	1.0000
5:94630502:G:GC	acceptor_loss	1.0000
5:94630502:GGAAA:G	acceptor_gain	1.0000
5:94630694:A:T	donor_gain	1.0000
5:94630719:A:G	donor_gain	1.0000
5:94630725:G:GT	donor_gain	1.0000

AlphaMissense

7029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:94630508:T:A	W66R	0.999
5:94630508:T:C	W66R	0.999
5:94692085:T:A	W842R	0.999
5:94692085:T:C	W842R	0.999
5:94692092:C:A	P844H	0.999
5:94629114:T:C	L46P	0.998
5:94630556:T:A	W82R	0.998
5:94630556:T:C	W82R	0.998
5:94691587:T:C	C815R	0.998
5:94691589:C:G	C815W	0.998
5:94691656:G:C	D838H	0.998
5:94692074:A:C	D838A	0.998
5:94692074:A:T	D838V	0.998
5:94692087:G:C	W842C	0.998
5:94692087:G:T	W842C	0.998
5:94692092:C:G	P844R	0.998
5:94692103:G:C	A848P	0.998
5:94692107:G:A	C849Y	0.998
5:94692108:T:G	C849W	0.998
5:94692116:G:T	G852V	0.998
5:94692131:T:A	V857D	0.998
5:94692205:G:C	A882P	0.998
5:94692209:T:C	L883P	0.998
5:94692242:T:C	L894P	0.998
5:94630580:T:A	W90R	0.997
5:94630580:T:C	W90R	0.997
5:94630643:T:A	W111R	0.997
5:94630643:T:C	W111R	0.997
5:94630691:T:A	W127R	0.997
5:94630691:T:C	W127R	0.997

dbSNP variants (sampled 300 via entrez): RS1000017444 (5:94684538 A>C,G), RS1000024937 (5:94651247 T>C), RS1000040914 (5:94643149 C>A), RS1000088048 (5:94692683 A>G,T), RS1000129047 (5:94654791 G>C), RS1000153765 (5:94627979 C>T), RS1000180376 (5:94671677 T>C), RS1000199076 (5:94678357 G>T), RS1000240404 (5:94690705 A>C,G), RS1000310182 (5:94668880 G>C), RS1000353418 (5:94624829 A>G), RS1000359851 (5:94681637 ACCCTCCC>A), RS1000440133 (5:94675099 T>G), RS1000465751 (5:94630579 A>G), RS1000475474 (5:94633876 G>C,T)

Disease associations

OMIM: gene MIM:618467 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST010701_40	Cortical surface area (MOSTest)	9.000000e-23
GCST010702_25	Subcortical volume (MOSTest)	4.000000e-39
GCST010703_194	Brain morphology (MOSTest)	9.000000e-11
GCST90093325_9	Language functional connectivity	7.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0007797	language measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	5
trichostatin A	affects cotreatment, decreases expression	3
Cyclosporine	affects expression, decreases expression	3
Resveratrol	affects cotreatment, increases expression	2
Cisplatin	decreases expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Aflatoxin B1	affects expression, decreases methylation	2
TAK-243	increases sumoylation	1
aminomethylphosphonic acid (AMPA)	increases expression	1
dicrotophos	decreases expression	1
sulforaphane	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	affects methylation	1
potassium chromate(VI)	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	increases expression, affects cotreatment	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Glyphosate	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.