SMAD1-AS2

Summary

SMAD1-AS2 (SMAD1 antisense RNA 2, HGNC:49381) is a long non-coding RNA gene on chromosome 4q31.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49381
Approved symbol	SMAD1-AS2
Name	SMAD1 antisense RNA 2
Location	4q31.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250582
Ensembl biotype	lncRNA
Entrez	101927659
RNAcentral	URS000075A7B2 — lncRNA, 1123 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000508936, ENST00000658284, ENST00000813541, ENST00000813542, ENST00000813543, ENST00000813544, ENST00000813687

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508936 — 2 exons

Exon	Start	End
ENSE00002069895	145497073	145498066
ENSE00004214018	145502876	145502975

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 87.81.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0383 / max 28.4537, expressed in 3 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
54237	0.0234	3
54238	0.0096	3
54236	0.0053	3

Top tissues by expression

197 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	87.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.66	gold quality
left testis	UBERON:0004533	82.68	gold quality
right testis	UBERON:0004534	80.99	gold quality
testis	UBERON:0000473	80.65	gold quality
colonic epithelium	UBERON:0000397	66.66	gold quality
adult organism	UBERON:0007023	66.59	gold quality
bone marrow cell	CL:0002092	65.04	silver quality
sural nerve	UBERON:0015488	59.26	silver quality
pancreatic ductal cell	CL:0002079	59.09	silver quality
ganglionic eminence	UBERON:0004023	57.13	gold quality
calcaneal tendon	UBERON:0003701	56.26	gold quality
epithelial cell of pancreas	CL:0000083	54.54	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
tonsil	UBERON:0002372	53.29	silver quality
ileal mucosa	UBERON:0000331	52.92	silver quality
corpus callosum	UBERON:0002336	52.87	gold quality
tibialis anterior	UBERON:0001385	52.79	silver quality
hindlimb stylopod muscle	UBERON:0004252	52.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.04	silver quality
deltoid	UBERON:0001476	51.82	gold quality
monocyte	CL:0000576	51.19	silver quality
uterine cervix	UBERON:0000002	51.07	gold quality
muscle of leg	UBERON:0001383	50.88	gold quality
myocardium	UBERON:0002349	50.25	gold quality
tendon	UBERON:0000043	49.71	gold quality
islet of Langerhans	UBERON:0000006	49.22	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.