SMAD3-AS1

Summary

SMAD3-AS1 (SMAD3 antisense RNA 1, HGNC:56692) is a long non-coding RNA gene on chromosome 15q22.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56692
Approved symbol	SMAD3-AS1
Name	SMAD3 antisense RNA 1
Location	15q22.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC012568.1
Ensembl gene	ENSG00000259202
Ensembl biotype	lncRNA
Entrez	128266842
RNAcentral	URS00007DBA26 — lncRNA, 472 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000558463

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558463 — 3 exons

Exon	Start	End
ENSE00002542103	67142734	67143086
ENSE00002556234	67146051	67146141
ENSE00002560811	67146912	67146939

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 82.37.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	82.37	gold quality
skeletal muscle tissue	UBERON:0001134	79.86	gold quality
colonic epithelium	UBERON:0000397	76.68	gold quality
bone marrow cell	CL:0002092	71.82	silver quality
calcaneal tendon	UBERON:0003701	69.18	gold quality
tonsil	UBERON:0002372	68.31	gold quality
corpus callosum	UBERON:0002336	64.87	gold quality
bone marrow	UBERON:0002371	64.52	gold quality
urinary bladder	UBERON:0001255	63.81	gold quality
liver	UBERON:0002107	63.51	gold quality
kidney	UBERON:0002113	61.24	gold quality
lymph node	UBERON:0000029	60.65	gold quality
uterine cervix	UBERON:0000002	59.29	silver quality
blood	UBERON:0000178	58.92	gold quality
leukocyte	CL:0000738	58.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.46	gold quality
monocyte	CL:0000576	57.87	gold quality
primary visual cortex	UBERON:0002436	57.43	gold quality
islet of Langerhans	UBERON:0000006	55.96	gold quality
adult mammalian kidney	UBERON:0000082	55.39	gold quality
muscle of leg	UBERON:0001383	53.80	gold quality
prefrontal cortex	UBERON:0000451	53.66	gold quality
cortex of kidney	UBERON:0001225	53.13	gold quality
stomach	UBERON:0000945	52.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	52.59	gold quality
lung	UBERON:0002048	51.77	gold quality
myometrium	UBERON:0001296	51.50	silver quality
gastrocnemius	UBERON:0001388	51.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.74	gold quality
adrenal tissue	UBERON:0018303	49.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.