SMAD3-DT

Summary

SMAD3-DT (SMAD3 divergent transcript, HGNC:56759) is a long non-coding RNA gene on chromosome 15q22.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56759
Approved symbol	SMAD3-DT
Name	SMAD3 divergent transcript
Location	15q22.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259347
Ensembl biotype	lncRNA
Entrez	102723493
RNAcentral	URS0000A7714A — lncRNA, 1830 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000558071, ENST00000558097, ENST00000560662, ENST00000636067, ENST00000655852, ENST00000665471, ENST00000670149, ENST00000692307, ENST00000701435, ENST00000702335, ENST00000702367, ENST00000773419, ENST00000773420, ENST00000773421, ENST00000773422, ENST00000773423, ENST00000773424, ENST00000773425, ENST00000773426, ENST00000773427, ENST00000773428, ENST00000773429, ENST00000773430, ENST00000773431, ENST00000773432

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558071 — 5 exons

Exon	Start	End
ENSE00002547923	67059140	67059253
ENSE00002565115	66987158	66987647
ENSE00003776747	66986368	66986497
ENSE00003778248	66985442	66985483
ENSE00003781738	66984108	66984234

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 90.48.

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	90.48	gold quality
sural nerve	UBERON:0015488	87.25	gold quality
liver	UBERON:0002107	85.97	gold quality
body of pancreas	UBERON:0001150	82.93	gold quality
pancreatic ductal cell	CL:0002079	82.62	silver quality
kidney epithelium	UBERON:0004819	80.61	silver quality
adult mammalian kidney	UBERON:0000082	77.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.08	gold quality
duodenum	UBERON:0002114	76.28	gold quality
kidney	UBERON:0002113	74.77	gold quality
pancreas	UBERON:0001264	74.73	gold quality
adipose tissue	UBERON:0001013	73.19	gold quality
cortex of kidney	UBERON:0001225	72.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.95	gold quality
jejunal mucosa	UBERON:0000399	71.47	gold quality
adipose tissue of abdominal region	UBERON:0007808	68.29	gold quality
omental fat pad	UBERON:0010414	67.38	gold quality
peritoneum	UBERON:0002358	67.31	gold quality
ileal mucosa	UBERON:0000331	67.17	gold quality
ganglionic eminence	UBERON:0004023	66.52	gold quality
small intestine	UBERON:0002108	66.27	gold quality
bone marrow cell	CL:0002092	66.06	silver quality
adult organism	UBERON:0007023	65.94	gold quality
colonic epithelium	UBERON:0000397	65.68	silver quality
sperm	CL:0000019	65.26	silver quality
small intestine Peyer’s patch	UBERON:0003454	65.24	gold quality
amygdala	UBERON:0001876	64.32	gold quality
caudate nucleus	UBERON:0001873	63.01	gold quality
left testis	UBERON:0004533	62.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.