SMAD5-AS1

Summary

SMAD5-AS1 (SMAD5 antisense RNA 1, HGNC:30586) is a long non-coding RNA gene on chromosome 5q31.1.

Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of BMP signaling pathway.

Source: NCBI Gene 9597 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30586
Approved symbol	SMAD5-AS1
Name	SMAD5 antisense RNA 1
Location	5q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	DAMS
Ensembl gene	ENSG00000164621
Ensembl biotype	lncRNA
OMIM	620035
Entrez	9597
RNAcentral	URS0000759D45 — lncRNA, 1827 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000297163, ENST00000809702, ENST00000809703, ENST00000809704

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000297163 — 2 exons

Exon	Start	End
ENSE00004205768	136129504	136129781
ENSE00004205773	136133350	136134890

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 77.33.

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
upper leg skin	UBERON:0004262	77.33	gold quality
skin of abdomen	UBERON:0001416	67.45	gold quality
zone of skin	UBERON:0000014	64.19	gold quality
skin of hip	UBERON:0001554	63.36	gold quality
skin of leg	UBERON:0001511	62.20	gold quality
ventricular zone	UBERON:0003053	60.13	gold quality
ileal mucosa	UBERON:0000331	58.66	silver quality
tibialis anterior	UBERON:0001385	58.00	silver quality
ganglionic eminence	UBERON:0004023	57.19	silver quality
pancreatic ductal cell	CL:0002079	56.45	silver quality
calcaneal tendon	UBERON:0003701	55.25	gold quality
bone marrow cell	CL:0002092	54.85	gold quality
lower esophagus mucosa	UBERON:0035834	53.58	gold quality
epithelium of esophagus	UBERON:0001976	53.45	gold quality
esophagus squamous epithelium	UBERON:0006920	53.27	gold quality
mammalian vulva	UBERON:0000997	52.12	silver quality
deltoid	UBERON:0001476	52.11	gold quality
adrenal tissue	UBERON:0018303	51.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	50.81	silver quality
esophagus mucosa	UBERON:0002469	50.79	gold quality
epithelial cell of pancreas	CL:0000083	50.58	gold quality
liver	UBERON:0002107	50.22	gold quality
tonsil	UBERON:0002372	50.03	silver quality
right lobe of liver	UBERON:0001114	49.82	silver quality
monocyte	CL:0000576	49.74	silver quality
mononuclear cell	CL:0000842	49.73	silver quality
prefrontal cortex	UBERON:0000451	49.70	silver quality
quadriceps femoris	UBERON:0001377	49.33	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.30	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• SMAD5-AS1 inhibits diffuse large B cell lymphoma proliferation by sponging miR-135b-5p to up-regulate APC expression and inactivate classic Wnt/beta-catenin pathway. (PMID:30874550)
• SMAD5-AS1 silencing suppressed epithelial-mesenchymal transition, cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC) by elevating miR-106a-5p to down-regulate SMAD5, which provided a novel therapeutic target for NPC treatment (PMID:31557058)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.