SMANTIS

Summary

SMANTIS (SMARCA4 interacting SWI/SNF chromatin remodeling complex scaffold lncRNA, HGNC:54417) is a long non-coding RNA gene on chromosome 2p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54417
Approved symbol	SMANTIS
Name	SMARCA4 interacting SWI/SNF chromatin remodeling complex scaffold lncRNA
Location	2p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MANTIS, ANXA4-AS, n342419
Ensembl gene	ENSG00000288869
Ensembl biotype	lncRNA
Entrez	107985770
RNAcentral	URS000194B0DB — lncRNA, 4338 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000684786, ENST00000684858, ENST00000685260, ENST00000686342, ENST00000687837, ENST00000688376, ENST00000689941, ENST00000690450, ENST00000690676, ENST00000691088, ENST00000692020, ENST00000692113, ENST00000692156, ENST00000692298, ENST00000693376, ENST00000702919, ENST00000702944, ENST00000702948, ENST00000702970, ENST00000702989, ENST00000703014, ENST00000703019, ENST00000825611, ENST00000825612, ENST00000825613, ENST00000825614, ENST00000825615, ENST00000825616, ENST00000825617, ENST00000825618, ENST00000825619, ENST00000825620, ENST00000825621, ENST00000825622, ENST00000825623, ENST00000825624, ENST00000825625, ENST00000825626, ENST00000825627, ENST00000825628, ENST00000825629, ENST00000825630, ENST00000825631, ENST00000825632, ENST00000825633, ENST00000825634, ENST00000825635, ENST00000825636, ENST00000825637, ENST00000825638, ENST00000825639, ENST00000825640, ENST00000825641, ENST00000825642, ENST00000825643, ENST00000825644

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000684786 — 3 exons

Exon	Start	End
ENSE00003926484	69794073	69794238
ENSE00003987738	69789544	69789926
ENSE00004236029	69798788	69799012

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Authors describe that lncRNA MANTIS (alias AK125871) is controlled by histone demethylase JARID1B and important to facilitate endothelial angiogenic gene expression and nucleosome remodelling by interaction and promotion of BRG1. The lncRNA acts through its Alu element and is required for spheroid outgrowth, tube formation, misregulated in pulmonary hypertension and glioblastoma and inducible with laminar flow. (PMID:28351900)
• LncRNA MANTIS is inducible by laminar flow and statins through transcription factors KLF2 and KLF4. Loss of MANTIS increased endothelial monocyte adhesion in an ICAM-1-dependent manner. Gene expression and functional responses of endothelial cells to laminar flow and statins are dependent on MANTIS. (PMID:31222221)
• RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions. (PMID:39271940)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.