SMAP1

Summary

SMAP1 (small ArfGAP 1, HGNC:19651) is a protein-coding gene on chromosome 6q13, encoding Stromal membrane-associated protein 1 (Q8IYB5). GTPase activating protein that acts on ARF6.

The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 60682 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 30 total — 1 pathogenic
• MANE Select transcript: NM_001044305

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19651
Approved symbol	SMAP1
Name	small ArfGAP 1
Location	6q13
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13159, SMAP-1
Ensembl gene	ENSG00000112305
Ensembl biotype	protein_coding
OMIM	611372
Entrez	60682

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 protein_coding

ENST00000316999, ENST00000370452, ENST00000370455, ENST00000439432, ENST00000445046, ENST00000619054, ENST00000894939, ENST00000894940, ENST00000894941, ENST00000894942, ENST00000939436, ENST00000939437, ENST00000960745, ENST00000960746, ENST00000960747, ENST00000960748, ENST00000960749, ENST00000960750

RefSeq mRNA: 4 — MANE Select: NM_001044305 NM_001044305, NM_001281439, NM_001281440, NM_021940

CCDS: CCDS43478, CCDS4973, CCDS64459, CCDS75478

Canonical transcript exons

ENST00000370455 — 11 exons

Exon	Start	End
ENSE00000810375	70773350	70773425
ENSE00001945773	70860200	70862003
ENSE00002228382	70798657	70798737
ENSE00002233840	70856859	70857030
ENSE00002280036	70836941	70837028
ENSE00002305102	70852540	70852664
ENSE00002310177	70857922	70858229
ENSE00002473371	70754980	70755065
ENSE00002502737	70732378	70732511
ENSE00003789586	70791689	70791769
ENSE00003894004	70667883	70668141

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 97.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.5648 / max 157.9496, expressed in 1812 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
68478	19.7879	1805
68476	7.1794	1736
68479	2.0413	1187
68477	1.1681	807
68480	0.2274	100
68475	0.1607	76

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	97.03	gold quality
jejunal mucosa	UBERON:0000399	96.38	gold quality
mucosa of sigmoid colon	UBERON:0004993	94.98	gold quality
colonic mucosa	UBERON:0000317	94.94	gold quality
esophagus squamous epithelium	UBERON:0006920	94.63	gold quality
epithelium of esophagus	UBERON:0001976	94.45	gold quality
oral cavity	UBERON:0000167	94.17	gold quality
pons	UBERON:0000988	93.88	gold quality
jejunum	UBERON:0002115	93.28	gold quality
pharyngeal mucosa	UBERON:0000355	92.89	gold quality
duodenum	UBERON:0002114	92.85	gold quality
squamous epithelium	UBERON:0006914	92.55	gold quality
skin of hip	UBERON:0001554	92.44	gold quality
upper leg skin	UBERON:0004262	92.44	gold quality
islet of Langerhans	UBERON:0000006	92.01	gold quality
ganglionic eminence	UBERON:0004023	91.87	gold quality
superior vestibular nucleus	UBERON:0007227	91.75	gold quality
superior surface of tongue	UBERON:0007371	91.72	gold quality
sural nerve	UBERON:0015488	91.54	gold quality
rectum	UBERON:0001052	91.28	gold quality
penis	UBERON:0000989	91.17	gold quality
ileal mucosa	UBERON:0000331	90.95	gold quality
left testis	UBERON:0004533	90.86	gold quality
heart right ventricle	UBERON:0002080	90.81	gold quality
gastrocnemius	UBERON:0001388	90.79	gold quality
gingiva	UBERON:0001828	90.51	gold quality
sperm	CL:0000019	90.48	gold quality
muscle of leg	UBERON:0001383	90.45	gold quality
pancreas	UBERON:0001264	90.43	gold quality
testis	UBERON:0000473	90.39	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.72
E-MTAB-6386	no	220.66
E-CURD-112	no	2.42

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SMAD5

miRNA regulators (miRDB)

128 targeting SMAP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-22-3P	99.93	68.13	917

Literature-anchored findings (GeneRIF, showing 5)

• SMAP1 may be an ADP-ribosylation factor 6 (Arf6)GAP that specifically regulates one of the multiple functions of Arf6, namely, clathrin-dependent endocytosis (PMID:15659652)
• SMAP1 loss-of-function mutations in microsatellite instability colorectal cancer may contribute to the emerging oncogenic pathway involving abnormal Arf6 regulation. (PMID:23752192)
• Results also demonstrated a physical association between SMAP1 and SMAP2, which might serve as a basis for a functional interaction, and identified the intramolecular domains responsible for this association (PMID:25281535)
• The study identified a region on chromosome 6 comprising the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism. (PMID:28011674)
• Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion. (PMID:36494580)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	smap1	ENSDARG00000031302
mus_musculus	Smap1	ENSMUSG00000026155
rattus_norvegicus	Smap1	ENSRNOG00000049127

Paralogs (28): ARAP2 (ENSG00000047365), ACAP1 (ENSG00000072818), SMAP2 (ENSG00000084070), ASAP3 (ENSG00000088280), ARFGAP1 (ENSG00000101199), ADAP1 (ENSG00000105963), AGFG2 (ENSG00000106351), GIT1 (ENSG00000108262), ACAP2 (ENSG00000114331), ARAP3 (ENSG00000120318), ACAP3 (ENSG00000131584), AGAP3 (ENSG00000133612), AGAP2 (ENSG00000135439), APPL2 (ENSG00000136044), GIT2 (ENSG00000139436), ARFGAP2 (ENSG00000149182), ASAP2 (ENSG00000151693), ASAP1 (ENSG00000153317), APPL1 (ENSG00000157500), AGAP1 (ENSG00000157985), AGAP5 (ENSG00000172650), AGFG1 (ENSG00000173744), ADAP2 (ENSG00000184060), ARAP1 (ENSG00000186635), AGAP4 (ENSG00000188234), AGAP6 (ENSG00000204149), AGAP9 (ENSG00000204172), ARFGAP3 (ENSG00000242247)

Protein

Protein identifiers

Stromal membrane-associated protein 1 — Q8IYB5 (reviewed: Q8IYB5)

All UniProt accessions (4): A0A087X1X9, Q8IYB5, H0Y5G0, Q5T6I8

UniProt curated annotations — full annotation on UniProt →

Function. GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis.

Subunit / interactions. Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif.

Subcellular location. Cell membrane.

Tissue specificity. Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8IYB5-1	1, SMAP1A	yes
Q8IYB5-2	2, SMAP1B
Q8IYB5-3	3

RefSeq proteins (4): NP_001037770, NP_001268368, NP_001268369, NP_068759 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001164	ArfGAP_dom	Domain
IPR037278	ARFGAP/RecO	Homologous_superfamily
IPR038508	ArfGAP_dom_sf	Homologous_superfamily
IPR044732	ArfGAP_SMAP1-like	Domain
IPR051718	ARF_GTPase-activating	Family

Pfam: PF01412

UniProt features (29 total): helix 8, compositionally biased region 5, turn 3, strand 3, splice variant 2, region of interest 2, chain 1, domain 1, sequence variant 1, sequence conflict 1, zinc finger region 1, short sequence motif 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2CRR	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IYB5-F1	62.06	0.30

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 190 (showing top): GOBP_MYELOID_CELL_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION, GOBP_MYELOID_CELL_HOMEOSTASIS, ATACCTC_MIR202, GOBP_ERYTHROCYTE_HOMEOSTASIS, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_HEMOPOIESIS, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS, GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION, ACATTCC_MIR1_MIR206, GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION

GO Biological Process (2): positive regulation of erythrocyte differentiation (GO:0045648), regulation of clathrin-dependent endocytosis (GO:2000369)

GO Molecular Function (5): GTPase activator activity (GO:0005096), zinc ion binding (GO:0008270), clathrin binding (GO:0030276), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
erythrocyte differentiation	1
positive regulation of myeloid cell differentiation	1
regulation of erythrocyte differentiation	1
regulation of receptor-mediated endocytosis	1
clathrin-dependent endocytosis	1
GTPase activity	1
enzyme activator activity	1
GTPase regulator activity	1
transition metal ion binding	1
protein binding	1
binding	1
cation binding	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

736 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SMAP1	MAP1B	P46821	671
SMAP1	ARF6	P26438	644
SMAP1	CLTC	Q00610	563
SMAP1	DENND5B	Q6ZUT9	521
SMAP1	LGSN	Q5TDP6	507
SMAP1	CLSTN1	O94985	498
SMAP1	RASA1	P20936	481
SMAP1	LYG1	Q8N1E2	478
SMAP1	TBCD	Q9BTW9	473
SMAP1	TFRC	P02786	470
SMAP1	RBP2	P50120	449
SMAP1	ZSWIM3	Q96MP5	447
SMAP1	IFT70A	Q86WT1	434
SMAP1	EPM2AIP1	Q7L775	419
SMAP1	OR4Q3	Q8NH05	410

IntAct

29 interactions, top by confidence:

A	B	Type	Score
CNOT3	CNOT1	psi-mi:“MI:0914”(association)	0.740
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
ZNF829	TRIM28	psi-mi:“MI:0914”(association)	0.530
GPS1	PXDNL	psi-mi:“MI:0914”(association)	0.530
HSPA2	DNAJC13	psi-mi:“MI:0914”(association)	0.530
OIP5	CYTH3	psi-mi:“MI:0914”(association)	0.530
ENG	SMAP1	psi-mi:“MI:0407”(direct interaction)	0.440
SMAP1	NPW	psi-mi:“MI:0915”(physical association)	0.400
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
SLC16A11	ESYT2	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
hspa1a_hspa1b_human-1	SHTN1	psi-mi:“MI:0914”(association)	0.350
MICU2	ACOX3	psi-mi:“MI:0914”(association)	0.350
B3GALT2	LIG1	psi-mi:“MI:0914”(association)	0.350
DDX28	UBA6	psi-mi:“MI:0914”(association)	0.350
HSPA8	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
MMP14	BIN1	psi-mi:“MI:0914”(association)	0.350
MRPL49	UBA6	psi-mi:“MI:0914”(association)	0.350
LRRK2	SF3B1	psi-mi:“MI:0914”(association)	0.350
ALK	NUDT19	psi-mi:“MI:2364”(proximity)	0.270
EGFR	FAM171A2	psi-mi:“MI:2364”(proximity)	0.270
FGFR1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
FGFR4	SH3PXD2B	psi-mi:“MI:2364”(proximity)	0.270
ROR2	SH3PXD2B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (76): SMAP1 (Affinity Capture-MS), HSPA1L (Affinity Capture-MS), KLHL18 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), KLHL18 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), SMAP1 (Affinity Capture-MS), ARF6 (Biochemical Activity), CLTC (Reconstituted Complex)

ESM2 similar proteins: A0JMZ1, A1L209, A1L2F3, A1L3I5, A2AWT3, A4FUE7, A6QQM4, O82171, O94519, P97868, Q08AZ1, Q14CW9, Q1W1G1, Q22122, Q2HJG4, Q2YDJ0, Q32KN7, Q5EAW4, Q5PPV5, Q5REC0, Q5TFG8, Q5ZMS6, Q618K0, Q62920, Q64GL0, Q66HC1, Q6DGN6, Q6NRP6, Q6P1U3, Q6V5K9, Q7SXT7, Q7Z6E9, Q801E2, Q8BJH1, Q8CI51, Q8H100, Q8IMP6, Q8IYB5, Q8R550, Q91W18

Diamond homologs: A1L520, A1Z7A6, A5PK26, A6NIR3, O43150, O74345, O75689, O80925, O82171, O94601, O97902, P35197, P38682, P40529, P52594, Q04412, Q09531, Q0WQQ1, Q10165, Q10367, Q14161, Q15027, Q15057, Q17R07, Q1AAU6, Q1ZXH8, Q28CM8, Q2TA45, Q3MID3, Q3UHD9, Q4KLH5, Q4KLN7, Q4LDD4, Q4R4C9, Q5F413, Q5FVC7, Q5R787, Q5RAT7, Q5U464, Q5VTM2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	25
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
4278487	NM_001044305.3(SMAP1):c.577-1G>T	Pathogenic

SpliceAI

3985 predictions. Top by Δscore:

Variant	Effect	Δscore
6:70670053:G:GT	donor_gain	1.0000
6:70732357:T:TA	acceptor_gain	1.0000
6:70732371:A:AG	acceptor_gain	1.0000
6:70732375:TAG:T	acceptor_loss	1.0000
6:70732376:A:AT	acceptor_loss	1.0000
6:70732377:G:A	acceptor_loss	1.0000
6:70732507:TACAG:T	donor_loss	1.0000
6:70732508:ACAG:A	donor_loss	1.0000
6:70732509:CAG:C	donor_loss	1.0000
6:70732510:AGG:A	donor_loss	1.0000
6:70732511:GGTAA:G	donor_loss	1.0000
6:70732512:G:T	donor_loss	1.0000
6:70732513:T:G	donor_loss	1.0000
6:70754975:TATA:T	acceptor_loss	1.0000
6:70754977:TAGT:T	acceptor_loss	1.0000
6:70754978:A:AG	acceptor_gain	1.0000
6:70754978:AGT:A	acceptor_gain	1.0000
6:70754978:AGTG:A	acceptor_loss	1.0000
6:70754979:G:GT	acceptor_gain	1.0000
6:70754979:GT:G	acceptor_gain	1.0000
6:70754979:GTG:G	acceptor_gain	1.0000
6:70754979:GTGC:G	acceptor_gain	1.0000
6:70754979:GTGCA:G	acceptor_gain	1.0000
6:70755061:GATCA:G	donor_gain	1.0000
6:70755062:A:G	donor_gain	1.0000
6:70755066:G:GG	donor_gain	1.0000
6:70830704:G:GT	donor_gain	1.0000
6:70836938:A:G	acceptor_gain	1.0000
6:70836939:A:AT	acceptor_loss	1.0000
6:70836939:A:G	acceptor_gain	1.0000

AlphaMissense

3066 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:70668085:T:A	L21Q	1.000
6:70668085:T:C	L21P	1.000
6:70668094:T:C	L24P	1.000
6:70668097:T:C	L25P	1.000
6:70668113:C:A	N30K	1.000
6:70668113:C:G	N30K	1.000
6:70668120:T:A	C33S	1.000
6:70668120:T:C	C33R	1.000
6:70668120:T:G	C33G	1.000
6:70668121:G:A	C33Y	1.000
6:70668121:G:C	C33S	1.000
6:70668121:G:T	C33F	1.000
6:70668122:C:G	C33W	1.000
6:70668124:C:A	A34D	1.000
6:70668126:G:C	D35H	1.000
6:70668126:G:T	D35Y	1.000
6:70668129:T:A	C36S	1.000
6:70668129:T:C	C36R	1.000
6:70668130:G:A	C36Y	1.000
6:70668130:G:C	C36S	1.000
6:70668130:G:T	C36F	1.000
6:70668131:C:G	C36W	1.000
6:70668135:G:C	A38P	1.000
6:70732380:C:T	P41S	1.000
6:70732381:C:A	P41H	1.000
6:70732381:C:G	P41R	1.000
6:70732384:G:C	R42P	1.000
6:70732386:T:A	W43R	1.000
6:70732386:T:C	W43R	1.000
6:70732386:T:G	W43G	1.000

dbSNP variants (sampled 300 via entrez): RS1000004784 (6:70722014 T>C), RS1000015608 (6:70787051 A>G), RS1000021285 (6:70754876 TAATA>T), RS1000024910 (6:70778394 T>C), RS1000025287 (6:70819231 T>G), RS1000039322 (6:70674195 C>T), RS1000042444 (6:70744017 T>A), RS1000047296 (6:70851004 G>A,T), RS1000054277 (6:70734399 G>T), RS1000070890 (6:70728141 A>G), RS1000074824 (6:70765671 G>A), RS1000107162 (6:70686662 A>G), RS1000109817 (6:70667966 C>A,T), RS1000150335 (6:70674244 C>A), RS1000156781 (6:70825876 C>T)

Disease associations

OMIM: gene MIM:611372 | disease phenotypes: MIM:617391

GenCC curated gene-disease

Mondo (1): developmental and epileptic encephalopathy, 54 (MONDO:0033363)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003518_15	Daytime sleep phenotypes	4.000000e-06
GCST009193_5	Pars opercularis volume	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007828	daytime rest measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
cobaltous chloride	increases expression	2
Valproic Acid	affects expression, decreases expression, increases methylation	2
Cadmium Chloride	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
chloroacetaldehyde	affects expression	1
triphenyl phosphate	affects expression	1
uranyl acetate	affects expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
adefovir dipivoxil	decreases expression	1
ICG 001	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Cidofovir	decreases expression	1
Air Pollutants	increases abundance, decreases expression	1
Ethanol	increases expression	1
Benzo(a)pyrene	increases methylation	1
Carbamazepine	affects expression	1
Carcinogens	decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Clodronic Acid	increases expression	1
Dieldrin	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Mutagens	decreases expression	1
Oxygen	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.