SMC2-DT

Summary

SMC2-DT (SMC2 divergent transcript, HGNC:50827) is a long non-coding RNA gene on chromosome 9q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50827
Approved symbol	SMC2-DT
Name	SMC2 divergent transcript
Location	9q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000270332
Ensembl biotype	lncRNA
Entrez	101928550
RNAcentral	URS00003E9E7E — lncRNA, 7020 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000603487, ENST00000603949, ENST00000664068, ENST00000691653, ENST00000701397, ENST00000701613, ENST00000773568, ENST00000773569, ENST00000773570, ENST00000773571, ENST00000773572, ENST00000773573, ENST00000773574, ENST00000773575, ENST00000773576, ENST00000773577, ENST00000773578, ENST00000773579, ENST00000773580, ENST00000773581, ENST00000773582, ENST00000773583, ENST00000773584, ENST00000773585, ENST00000773586, ENST00000773587, ENST00000773588, ENST00000773589, ENST00000773590

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000603487 — 3 exons

Exon	Start	End
ENSE00003492369	104087040	104087155
ENSE00003542518	104092089	104092474
ENSE00003569986	104080024	104086541

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 80.85.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1167 / max 7.6271, expressed in 79 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101777	0.1167	79

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	80.85	gold quality
thymus	UBERON:0002370	80.33	gold quality
right uterine tube	UBERON:0001302	76.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.22	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.45	silver quality
quadriceps femoris	UBERON:0001377	69.42	gold quality
lower esophagus	UBERON:0013473	67.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.76	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.06	gold quality
body of uterus	UBERON:0009853	66.46	gold quality
myometrium	UBERON:0001296	66.32	gold quality
cortical plate	UBERON:0005343	66.19	gold quality
heart left ventricle	UBERON:0002084	65.78	gold quality
apex of heart	UBERON:0002098	65.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.48	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.25	gold quality
right coronary artery	UBERON:0001625	64.80	gold quality
descending thoracic aorta	UBERON:0002345	64.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.56	gold quality
ascending aorta	UBERON:0001496	64.52	gold quality
smooth muscle tissue	UBERON:0001135	64.41	gold quality
thoracic aorta	UBERON:0001515	64.29	gold quality
cerebellar hemisphere	UBERON:0002245	64.23	gold quality
cerebellar cortex	UBERON:0002129	63.98	gold quality
rectum	UBERON:0001052	63.95	gold quality
cerebellum	UBERON:0002037	63.92	gold quality
fallopian tube	UBERON:0003889	63.87	gold quality
endometrium	UBERON:0001295	63.59	gold quality
heart	UBERON:0000948	63.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.