SMCR2

Summary

SMCR2 (Smith-Magenis syndrome chromosome region, candidate 2, HGNC:17914) is a long non-coding RNA gene on chromosome 17p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17914
Approved symbol	SMCR2
Name	Smith-Magenis syndrome chromosome region, candidate 2
Location	17p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223979
Ensembl biotype	lncRNA
Entrez	105371564
RNAcentral	URS00005BADDF — lncRNA, 564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456090

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456090 — 4 exons

Exon	Start	End
ENSE00001613428	17676210	17676371
ENSE00001622487	17675366	17675522
ENSE00001654437	17674026	17674156
ENSE00002041670	17677575	17677688

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 93.51.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.89	gold quality
ventricular zone	UBERON:0003053	68.46	gold quality
ganglionic eminence	UBERON:0004023	64.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.28	gold quality
sural nerve	UBERON:0015488	62.24	silver quality
cortical plate	UBERON:0005343	60.73	gold quality
islet of Langerhans	UBERON:0000006	57.37	gold quality
prefrontal cortex	UBERON:0000451	56.85	gold quality
left testis	UBERON:0004533	56.09	gold quality
testis	UBERON:0000473	55.83	gold quality
right testis	UBERON:0004534	55.32	gold quality
stromal cell of endometrium	CL:0002255	55.01	silver quality
bone marrow	UBERON:0002371	54.88	gold quality
smooth muscle tissue	UBERON:0001135	54.53	gold quality
duodenum	UBERON:0002114	53.86	gold quality
primary visual cortex	UBERON:0002436	53.39	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.35	gold quality
adrenal tissue	UBERON:0018303	53.09	gold quality
lymph node	UBERON:0000029	52.77	gold quality
blood	UBERON:0000178	52.34	gold quality
monocyte	CL:0000576	52.12	silver quality
frontal cortex	UBERON:0001870	51.65	gold quality
liver	UBERON:0002107	51.58	gold quality
tonsil	UBERON:0002372	51.40	gold quality
right lobe of liver	UBERON:0001114	51.03	gold quality
urinary bladder	UBERON:0001255	50.93	gold quality
putamen	UBERON:0001874	50.77	gold quality
cerebral cortex	UBERON:0000956	50.33	gold quality
gall bladder	UBERON:0002110	50.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.