SMG6-IT1

Summary

SMG6-IT1 (SMG6 intronic transcript 1, HGNC:1220) is a long non-coding RNA gene on chromosome 17p13.3.

At a glance

• Gene type: non-coding (TEC) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1220
Approved symbol	SMG6-IT1
Name	SMG6 intronic transcript 1
Location	17p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000278941
Ensembl biotype	TEC
Entrez	53400
RNAcentral	URS00008B9F9B — lncRNA, 374 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 TEC

ENST00000624930

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624930 — 1 exons

Exon	Start	End
ENSE00003759436	2235713	2236086

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 93.10.

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.10	gold quality
bone marrow cell	CL:0002092	71.93	silver quality
colonic epithelium	UBERON:0000397	71.83	gold quality
sural nerve	UBERON:0015488	68.18	gold quality
bone marrow	UBERON:0002371	66.83	gold quality
monocyte	CL:0000576	63.92	gold quality
skeletal muscle tissue	UBERON:0001134	63.54	gold quality
calcaneal tendon	UBERON:0003701	62.15	gold quality
urinary bladder	UBERON:0001255	61.87	silver quality
islet of Langerhans	UBERON:0000006	60.78	gold quality
liver	UBERON:0002107	58.92	gold quality
prefrontal cortex	UBERON:0000451	58.21	gold quality
tonsil	UBERON:0002372	57.98	silver quality
corpus callosum	UBERON:0002336	57.68	gold quality
blood	UBERON:0000178	56.93	gold quality
adrenal tissue	UBERON:0018303	55.61	gold quality
muscle of leg	UBERON:0001383	55.31	gold quality
primary visual cortex	UBERON:0002436	55.10	gold quality
kidney	UBERON:0002113	54.35	gold quality
uterine cervix	UBERON:0000002	54.23	gold quality
endometrium	UBERON:0001295	54.21	gold quality
right lobe of liver	UBERON:0001114	52.46	gold quality
lung	UBERON:0002048	52.35	gold quality
gastrocnemius	UBERON:0001388	52.29	gold quality
substantia nigra	UBERON:0002038	51.94	gold quality
stomach	UBERON:0000945	51.39	gold quality
adult mammalian kidney	UBERON:0000082	50.88	gold quality
tibial artery	UBERON:0007610	50.35	gold quality
popliteal artery	UBERON:0002250	50.31	gold quality
heart	UBERON:0000948	50.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.