SMILR

Summary

SMILR (smooth muscle induced lncRNA, enhancer of proliferation, HGNC:51825) is a long non-coding RNA gene on chromosome 8q24.13.

Involved in positive regulation of gene expression and positive regulation of vascular associated smooth muscle cell proliferation. Located in cytoplasm; extracellular space; and nucleus.

Source: NCBI Gene 105375734 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51825
Approved symbol	SMILR
Name	smooth muscle induced lncRNA, enhancer of proliferation
Location	8q24.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255364
Ensembl biotype	lncRNA
Entrez	105375734
RNAcentral	URS000081211C — lncRNA, 569 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000533992

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000533992 — 3 exons

Exon	Start	End
ENSE00002155400	122428421	122428551
ENSE00002158567	122414332	122414555
ENSE00002177014	122416825	122417022

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 78.35.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0937 / max 206.8766, expressed in 274 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94674	0.6021	165
94675	0.1631	63
94676	0.1377	41
94678	0.0922	31
94680	0.0576	18
94677	0.0263	6
94679	0.0146	3

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.35	gold quality
esophagus mucosa	UBERON:0002469	74.64	gold quality
ectocervix	UBERON:0012249	71.09	gold quality
esophagus	UBERON:0001043	70.86	gold quality
bone marrow	UBERON:0002371	70.15	gold quality
bone marrow cell	CL:0002092	67.66	silver quality
popliteal artery	UBERON:0002250	66.98	gold quality
left coronary artery	UBERON:0001626	66.95	gold quality
tibial artery	UBERON:0007610	66.94	gold quality
right coronary artery	UBERON:0001625	66.05	gold quality
right ovary	UBERON:0002118	65.92	gold quality
lower esophagus mucosa	UBERON:0035834	64.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.67	gold quality
stromal cell of endometrium	CL:0002255	63.24	gold quality
skeletal muscle tissue	UBERON:0001134	61.38	gold quality
lymph node	UBERON:0000029	60.31	gold quality
uterine cervix	UBERON:0000002	59.64	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.31	gold quality
vagina	UBERON:0000996	59.26	gold quality
prefrontal cortex	UBERON:0000451	58.91	gold quality
blood	UBERON:0000178	58.55	gold quality
minor salivary gland	UBERON:0001830	58.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.84	gold quality
heart	UBERON:0000948	57.63	gold quality
urinary bladder	UBERON:0001255	56.64	gold quality
cerebellum	UBERON:0002037	56.55	gold quality
cerebellar hemisphere	UBERON:0002245	56.55	gold quality
cerebellar cortex	UBERON:0002129	56.51	gold quality
islet of Langerhans	UBERON:0000006	56.28	gold quality
heart left ventricle	UBERON:0002084	56.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension. (PMID:32559140)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.