SMIM2-AS1

Summary

SMIM2-AS1 (SMIM2 antisense RNA 1, HGNC:42674) is a long non-coding RNA gene on chromosome 13q14.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42674
Approved symbol	SMIM2-AS1
Name	SMIM2 antisense RNA 1
Location	13q14.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227258
Ensembl biotype	lncRNA
Entrez	101929212
RNAcentral	URS000075D262 — lncRNA, 1205 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 42 lncRNA

ENST00000437867, ENST00000444663, ENST00000616366, ENST00000618753, ENST00000619472, ENST00000654757, ENST00000659169, ENST00000666499, ENST00000762341, ENST00000762342, ENST00000762343, ENST00000762344, ENST00000762345, ENST00000762346, ENST00000762347, ENST00000762348, ENST00000762349, ENST00000762350, ENST00000762351, ENST00000762352, ENST00000762353, ENST00000762354, ENST00000762355, ENST00000762356, ENST00000762357, ENST00000762358, ENST00000762359, ENST00000762360, ENST00000762361, ENST00000762362, ENST00000762363, ENST00000762364, ENST00000762365, ENST00000762366, ENST00000762367, ENST00000762368, ENST00000762369, ENST00000762370, ENST00000762549, ENST00000762550, ENST00000762551, ENST00000762552

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437867 — 3 exons

Exon	Start	End
ENSE00001732111	44146782	44146855
ENSE00001733442	44142321	44143737
ENSE00001776526	44238828	44240054

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 94.00.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2276 / max 40.7519, expressed in 570 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134928	1.1693	570
134927	0.0373	10
134926	0.0210	8

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	94.00	gold quality
adult mammalian kidney	UBERON:0000082	80.82	gold quality
mucosa of transverse colon	UBERON:0004991	80.71	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.28	gold quality
right lobe of liver	UBERON:0001114	79.77	gold quality
left testis	UBERON:0004533	79.58	gold quality
right testis	UBERON:0004534	78.13	gold quality
testis	UBERON:0000473	77.81	gold quality
rectum	UBERON:0001052	76.70	gold quality
cortex of kidney	UBERON:0001225	76.54	gold quality
metanephros cortex	UBERON:0010533	75.96	gold quality
liver	UBERON:0002107	73.84	gold quality
sperm	CL:0000019	73.65	gold quality
apex of heart	UBERON:0002098	73.48	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.40	gold quality
colonic epithelium	UBERON:0000397	72.64	gold quality
transverse colon	UBERON:0001157	72.24	gold quality
kidney	UBERON:0002113	72.01	gold quality
small intestine Peyer’s patch	UBERON:0003454	71.11	gold quality
small intestine	UBERON:0002108	70.34	gold quality
heart left ventricle	UBERON:0002084	69.80	gold quality
cardiac ventricle	UBERON:0002082	69.16	gold quality
islet of Langerhans	UBERON:0000006	67.45	gold quality
right adrenal gland cortex	UBERON:0035827	67.40	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.27	gold quality
intestine	UBERON:0000160	66.88	gold quality
body of stomach	UBERON:0001161	66.53	gold quality
colon	UBERON:0001155	66.08	gold quality
colonic mucosa	UBERON:0000317	66.06	gold quality
large intestine	UBERON:0000059	65.97	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	52.55
E-ANND-3	no	3.50

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.