SMIM32

Summary

SMIM32 (small integral membrane protein 32, HGNC:53640) is a protein-coding gene on chromosome 5q31.1, encoding Small integral membrane protein 32 (A0A1B0GUA5).

Predicted to be located in membrane.

Source: NCBI Gene 389332 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001350994

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53640
Approved symbol	SMIM32
Name	small integral membrane protein 32
Location	5q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000271824
Ensembl biotype	protein_coding
Entrez	389332

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000607574

RefSeq mRNA: 1 — MANE Select: NM_001350994 NM_001350994

CCDS: CCDS87324

Canonical transcript exons

ENST00000607574 — 1 exons

Exon	Start	End
ENSE00003696591	136191468	136193162

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 91.30.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3270 / max 31.0395, expressed in 128 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63590	0.3270	128

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	91.30	silver quality
adult mammalian kidney	UBERON:0000082	87.32	gold quality
kidney	UBERON:0002113	81.33	gold quality
duodenum	UBERON:0002114	81.23	gold quality
mucosa of transverse colon	UBERON:0004991	78.78	gold quality
vena cava	UBERON:0004087	77.51	gold quality
heart right ventricle	UBERON:0002080	76.90	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	75.42	gold quality
nasal cavity epithelium	UBERON:0005384	73.23	gold quality
renal medulla	UBERON:0000362	73.04	gold quality
jejunal mucosa	UBERON:0000399	72.55	silver quality
colonic mucosa	UBERON:0000317	72.18	gold quality
adult organism	UBERON:0007023	71.55	gold quality
metanephros cortex	UBERON:0010533	71.50	gold quality
cortex of kidney	UBERON:0001225	71.40	gold quality
cartilage tissue	UBERON:0002418	71.14	gold quality
putamen	UBERON:0001874	71.12	gold quality
jejunum	UBERON:0002115	70.98	silver quality
metanephros	UBERON:0000081	70.63	gold quality
mucosa of sigmoid colon	UBERON:0004993	70.42	gold quality
myocardium	UBERON:0002349	70.38	gold quality
lateral nuclear group of thalamus	UBERON:0002736	69.64	gold quality
pharyngeal mucosa	UBERON:0000355	69.62	gold quality
Brodmann (1909) area 46	UBERON:0006483	69.46	silver quality
upper arm skin	UBERON:0004263	69.41	gold quality
body of tongue	UBERON:0011876	68.82	gold quality
thymus	UBERON:0002370	68.81	gold quality
ileal mucosa	UBERON:0000331	68.39	gold quality
prefrontal cortex	UBERON:0000451	68.33	gold quality
layer of synovial tissue	UBERON:0007616	68.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.08

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Smim32	ENSMUSG00000110086
rattus_norvegicus	Smim32	ENSRNOG00000077112

Protein

Protein identifiers

Small integral membrane protein 32 — A0A1B0GUA5 (reviewed: A0A1B0GUA5)

All UniProt accessions (1): A0A1B0GUA5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (1): NP_001337923* (*=MANE)

Domains & families (InterPro)

UniProt features (2 total): chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GUA5-F1	61.35	0.17

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 11 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, PEREZ_TP63_TARGETS, chr5q31, BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_CALU3_CELLS_DN, DESCARTES_FETAL_LUNG_NEUROENDOCRINE_CELLS, DESCARTES_FETAL_PANCREAS_ISLET_ENDOCRINE_CELLS, HE_LIM_SUN_FETAL_LUNG_C1_PULMONARY_NE_PRECURSOR_CELL, HE_LIM_SUN_FETAL_LUNG_C1_PULMONARY_NEUROENDOCRINE_CELL, GSE29614_CTRL_VS_TIV_FLU_VACCINE_PBMC_2007_UP, GSE37416_CTRL_VS_0H_F_TULARENSIS_LVS_NEUTROPHIL_UP, GSE45365_HEALTHY_VS_MCMV_INFECTION_CD11B_DC_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

66 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SMIM32	GNB4	Q9HAV0	381
SMIM32	TMEM244	Q5VVB8	380
SMIM32	GPR87	Q9BY21	348
SMIM32	LYZL4	Q96KX0	338
SMIM32	SACK1A	Q86UY5	336
SMIM32	C1orf115	Q9H7X2	333
SMIM32	RASGEF1C	Q8N431	326
SMIM32	SLC25A21	Q9BQT8	260
SMIM32	DUSP13B	Q9UII6	257
SMIM32	KIF16B	Q96L93	250
SMIM32	KLK10	O43240	248
SMIM32	GNG2	P59768	242
SMIM32	TFAP2D	Q7Z6R9	233
SMIM32	NR4A2	P43354	225
SMIM32	ITGB6	P18564	224

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GUA5, A0A1B0GVQ0, A0A286YF18, A0JNN8, A2VDX9, A5PK62, A6NGB7, A9CBA0, O09800, P04488, P06480, P06764, P07646, P0C171, P0DJK0, P0DJK1, P0DMQ5, P13291, P22389, P36342, P46695, P98162, Q08102, Q1RMT9, Q2HJ59, Q3TYP4, Q5BIR3, Q5EAA5, Q5JTB6, Q5NRQ0, Q6F5E0, Q6VUC0, Q6VUP9, Q703F0, Q765Z5, Q867A9, Q867D0, Q89448, Q8MJW9, Q8TEF2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

638 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:136192307:A:T	I73N	0.968
5:136192340:A:C	L62R	0.967
5:136192319:A:T	V69D	0.958
5:136192322:A:T	L68H	0.957
5:136192322:A:C	L68R	0.955
5:136192340:A:T	L62Q	0.948
5:136192309:G:C	F72L	0.947
5:136192309:G:T	F72L	0.947
5:136192311:A:G	F72L	0.947
5:136192325:G:T	A67E	0.945
5:136192279:G:C	F82L	0.942
5:136192279:G:T	F82L	0.942
5:136192281:A:G	F82L	0.942
5:136192316:A:T	V70D	0.933
5:136192343:A:C	L61R	0.933
5:136192337:A:C	L63R	0.931
5:136192328:A:T	V66E	0.929
5:136192310:A:G	F72S	0.926
5:136192340:A:G	L62P	0.924
5:136192362:A:G	Y55H	0.924
5:136192334:A:C	L64R	0.921
5:136192352:A:T	L58H	0.920
5:136192280:A:C	F82C	0.913
5:136192334:A:T	L64H	0.907
5:136192295:A:G	L77P	0.904
5:136192352:A:C	L58R	0.901
5:136192362:A:C	Y55D	0.898
5:136192358:A:C	L56R	0.891
5:136192378:C:A	K49N	0.881
5:136192378:C:G	K49N	0.881

dbSNP variants (sampled 300 via entrez): RS1000073020 (5:136191378 G>C), RS1000124914 (5:136191208 C>A), RS1001816935 (5:136191999 A>T), RS1001930542 (5:136192127 G>A), RS1003456973 (5:136193162 C>A,T), RS1003488235 (5:136193318 C>A,T), RS1003935642 (5:136194713 A>G), RS10045073 (5:136194216 A>G), RS1005036312 (5:136194454 G>T), RS1005135223 (5:136194409 A>C,T), RS1006082756 (5:136191663 A>C,G,T), RS1007339654 (5:136193035 C>T), RS1007826037 (5:136193187 G>T), RS1008596402 (5:136191439 GCAAA>G), RS1008837026 (5:136191731 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
titanium dioxide	decreases expression	1
sodium arsenite	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment, decreases expression	1
Malathion	decreases expression	1
Valproic Acid	decreases expression	1
Gold Compounds	decreases expression	1
Permethrin	decreases expression	1
Particulate Matter	increases abundance, increases expression	1
Magnetite Nanoparticles	decreases expression, increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.