SMIM33

Summary

SMIM33 (small integral membrane protein 33, HGNC:53645) is a protein-coding gene on chromosome 5q31.2, encoding Small integral membrane protein 33 (A0A1B0GW64).

Predicted to be located in membrane.

Source: NCBI Gene 111064649 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001365197

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53645
Approved symbol	SMIM33
Name	small integral membrane protein 33
Location	5q31.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000283288
Ensembl biotype	protein_coding
Entrez	111064649

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000637503

RefSeq mRNA: 1 — MANE Select: NM_001365197 NM_001365197

CCDS: CCDS93790

Canonical transcript exons

ENST00000637503 — 2 exons

Exon	Start	End
ENSE00003798128	139472532	139473700
ENSE00003799688	139471004	139471130

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 67.96.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	67.96	gold quality
rectum	UBERON:0001052	63.08	gold quality
bone marrow cell	CL:0002092	56.13	gold quality
duodenum	UBERON:0002114	54.92	gold quality
granulocyte	CL:0000094	52.18	gold quality
transverse colon	UBERON:0001157	51.86	gold quality
colonic epithelium	UBERON:0000397	50.28	gold quality
vermiform appendix	UBERON:0001154	47.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.03	silver quality
small intestine	UBERON:0002108	45.56	gold quality
gall bladder	UBERON:0002110	44.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	44.74	gold quality
minor salivary gland	UBERON:0001830	44.19	gold quality
intestine	UBERON:0000160	43.89	gold quality
saliva-secreting gland	UBERON:0001044	43.67	gold quality
colon	UBERON:0001155	43.08	gold quality
lymph node	UBERON:0000029	41.91	gold quality
sural nerve	UBERON:0015488	41.15	gold quality
stromal cell of endometrium	CL:0002255	39.51	gold quality
ganglionic eminence	UBERON:0004023	38.87	gold quality
muscle tissue	UBERON:0002385	38.58	silver quality
apex of heart	UBERON:0002098	36.91	gold quality
smooth muscle tissue	UBERON:0001135	36.54	gold quality
skeletal muscle tissue	UBERON:0001134	36.51	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.42	gold quality
primary visual cortex	UBERON:0002436	36.09	gold quality
monocyte	CL:0000576	35.16	gold quality
fallopian tube	UBERON:0003889	35.00	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.08

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Smim33	ENSMUSG00000073598
rattus_norvegicus		ENSRNOG00000079652

Protein

Protein identifiers

Small integral membrane protein 33 — A0A1B0GW64 (reviewed: A0A1B0GW64)

All UniProt accessions (1): A0A1B0GW64

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (1): NP_001352126* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR038803	SMIM33	Family

UniProt features (5 total): region of interest 2, chain 1, transmembrane region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A1B0GW64-F1	62.22	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 15

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 2 (showing top): DARWICHE_PAPILLOMA_PROGRESSION_RISK, chr5q31

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

102 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SMIM33	SPATA24	Q86W54	665
SMIM33	DNAJC18	Q9H819	623
SMIM33	PROB1	E7EW31	571
SMIM33	FAM13B	Q9NYF5	499
SMIM33	LRRTM2	O43300	496
SMIM33	SIL1	Q9H173	476
SMIM33	PKD2L2	Q9NZM6	476
SMIM33	FAM221B	A6H8Z2	417
SMIM33	ECSCR	Q19T08	403
SMIM33	NME5	P56597	400
SMIM33	BRD8	Q9H0E9	368
SMIM33	SLC23A1	Q9UHI7	368
SMIM33	ATP10A	O60312	359
SMIM33	STING1	Q86WV6	353
SMIM33	CDC23	Q9UJX2	349

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A1B0GW64, A0A5F4BST2, A0PJX4, A8MVS5, A8MWV9, B0FP48, E5RIL1, E9PGG2, O14836, O60320, O95998, P09564, Q01113, Q01114, Q13477, Q2KI80, Q2T9R2, Q3TS39, Q3UPR0, Q3URD2, Q4V9L6, Q5FVJ4, Q5M869, Q6A044, Q6UWJ8, Q75VT8, Q864V4, Q8BRJ3, Q8BX43, Q8C503, Q8IVY1, Q8K5A9, Q8N112, Q8NC24, Q8NDY8, Q8QZT4, Q8R138, Q969Z4, Q9BUF7, Q9CQM1

Diamond homologs: A0A1B0GW64, Q3TS39

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

139 predictions. Top by Δscore:

Variant	Effect	Δscore
5:139472610:C:G	donor_gain	0.9400
5:139472604:G:GT	donor_gain	0.9100
5:139472606:GGTGC:G	donor_gain	0.8900
5:139472654:G:GA	donor_gain	0.8900
5:139472609:GC:G	donor_gain	0.8600
5:139472658:ACC:A	donor_gain	0.8600
5:139472705:GGC:G	donor_gain	0.8100
5:139472657:C:A	donor_gain	0.7800
5:139472653:T:TA	donor_gain	0.7600
5:139472784:G:GA	donor_gain	0.7600
5:139472594:G:GT	donor_gain	0.7400
5:139472616:G:GA	donor_gain	0.7400
5:139472638:T:G	donor_gain	0.7300
5:139472783:T:TA	donor_gain	0.7300
5:139472688:G:GT	donor_gain	0.7200
5:139472583:G:GT	donor_gain	0.6800
5:139472690:A:AG	acceptor_gain	0.6700
5:139472691:G:GG	acceptor_gain	0.6700
5:139472595:C:T	donor_gain	0.6500
5:139472625:G:T	donor_gain	0.6500
5:139472706:G:GT	donor_gain	0.6500
5:139472686:T:A	acceptor_gain	0.6300
5:139472625:G:GT	donor_gain	0.6100
5:139472668:T:TA	donor_gain	0.6100
5:139472904:G:GT	donor_gain	0.5900
5:139472615:T:TA	donor_gain	0.5800
5:139472919:T:TA	donor_gain	0.5700
5:139472920:A:AA	donor_gain	0.5700
5:139472607:GTGC:G	donor_gain	0.5200
5:139472608:TGCT:T	donor_gain	0.5200

AlphaMissense

838 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:139472676:T:C	F52L	0.963
5:139472678:T:A	F52L	0.963
5:139472678:T:G	F52L	0.963
5:139472694:T:C	C58R	0.963
5:139472689:C:A	A56E	0.941
5:139472680:T:A	V53D	0.930
5:139472804:G:C	W94C	0.923
5:139472804:G:T	W94C	0.923
5:139472701:T:A	I60K	0.912
5:139472683:T:G	L54R	0.889
5:139472692:T:A	V57D	0.889
5:139472802:T:A	W94R	0.874
5:139472802:T:C	W94R	0.874
5:139472686:T:G	L55R	0.854
5:139472668:T:A	V49D	0.853
5:139472701:T:G	I60R	0.849
5:139472677:T:G	F52C	0.842
5:139472710:T:A	V63D	0.837
5:139472698:T:A	I59N	0.829
5:139472677:T:C	F52S	0.823
5:139472665:T:A	I48N	0.811
5:139472671:C:A	A50D	0.789
5:139472803:G:T	W94L	0.786
5:139472698:T:C	I59T	0.782
5:139472683:T:A	L54Q	0.771
5:139472698:T:G	I59S	0.771
5:139472688:G:C	A56P	0.765
5:139472676:T:A	F52I	0.759
5:139472674:T:A	V51D	0.758
5:139472715:T:C	F65L	0.757

dbSNP variants (sampled 300 via entrez): RS1000577520 (5:139469884 A>AT), RS1000884653 (5:139469658 G>T), RS1001316995 (5:139469452 G>A), RS1001819796 (5:139469117 G>A), RS1002853592 (5:139473908 C>T), RS1002923375 (5:139472024 C>T), RS1003227575 (5:139473669 C>T), RS1004458866 (5:139473406 G>A), RS1004581428 (5:139473131 C>CG), RS1005103487 (5:139472864 C>T), RS1005480927 (5:139473273 C>T), RS1005784409 (5:139470701 G>A,T), RS1006074219 (5:139471938 G>T), RS1006484319 (5:139470664 C>T), RS1006518095 (5:139471770 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.