SMNDC1

Summary

SMNDC1 (survival motor neuron domain containing 1, HGNC:16900) is a protein-coding gene on chromosome 10q25.2, encoding Survival of motor neuron-related-splicing factor 30 (O75940). Involved in spliceosome assembly. It is a common-essential gene (DepMap: required in 98.8% of cancer cell lines).

This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.

Source: NCBI Gene 10285 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 16 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 98.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_005871

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16900
Approved symbol	SMNDC1
Name	survival motor neuron domain containing 1
Location	10q25.2
Locus type	gene with protein product
Status	Approved
Aliases	SPF30, SMNR, TDRD16C
Ensembl gene	ENSG00000119953
Ensembl biotype	protein_coding
OMIM	603519
Entrez	10285

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000369592, ENST00000369603, ENST00000460483, ENST00000471297, ENST00000477763, ENST00000674928, ENST00000889865, ENST00000934667, ENST00000934668, ENST00000934669, ENST00000934670, ENST00000934671, ENST00000934672, ENST00000934673

RefSeq mRNA: 1 — MANE Select: NM_005871 NM_005871

CCDS: CCDS7565

Canonical transcript exons

ENST00000369603 — 6 exons

Exon	Start	End
ENSE00000811825	110295228	110295381
ENSE00000811826	110297567	110297728
ENSE00001450419	110290730	110294287
ENSE00001450428	110304748	110304920
ENSE00003484819	110303468	110303587
ENSE00003573712	110298648	110298790

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 97.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.9813 / max 421.0361, expressed in 1819 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111383	38.2458	1819
111381	3.3537	1546
111382	1.3817	991

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amniotic fluid	UBERON:0000173	97.90	gold quality
buccal mucosa cell	CL:0002336	96.36	gold quality
germinal epithelium of ovary	UBERON:0001304	96.27	gold quality
cartilage tissue	UBERON:0002418	95.98	gold quality
gingival epithelium	UBERON:0001949	95.38	gold quality
parietal pleura	UBERON:0002400	94.84	gold quality
pigmented layer of retina	UBERON:0001782	94.81	gold quality
gingiva	UBERON:0001828	94.37	gold quality
adult organism	UBERON:0007023	94.33	gold quality
blood vessel layer	UBERON:0004797	94.31	gold quality
jejunal mucosa	UBERON:0000399	94.21	gold quality
palpebral conjunctiva	UBERON:0001812	94.17	gold quality
pleura	UBERON:0000977	94.01	gold quality
biceps brachii	UBERON:0001507	93.96	gold quality
secondary oocyte	CL:0000655	93.88	gold quality
upper leg skin	UBERON:0004262	93.88	gold quality
choroid plexus epithelium	UBERON:0003911	93.87	gold quality
skin of hip	UBERON:0001554	93.85	gold quality
oral cavity	UBERON:0000167	93.80	gold quality
visceral pleura	UBERON:0002401	93.80	gold quality
trabecular bone tissue	UBERON:0002483	93.73	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.68	gold quality
superficial temporal artery	UBERON:0001614	93.62	gold quality
oocyte	CL:0000023	93.52	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	92.93	gold quality
esophagus squamous epithelium	UBERON:0006920	92.52	gold quality
seminal vesicle	UBERON:0000998	92.36	gold quality
nephron tubule	UBERON:0001231	92.24	gold quality
cauda epididymis	UBERON:0004360	92.16	gold quality
jejunum	UBERON:0002115	92.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

125 targeting SMNDC1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-12136	99.98	72.81	5713
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-329-3P	99.91	66.56	1234

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 8)

• U2AF35 and hPrp3 interactions with SPF30 can occur simultaneously, thereby potentially linking 3’ splice site recognition with tri-small nuclear ribonucleoprotein addition (PMID:18211889)
• The structures of SMN and SPF30 Tudor domains bound to symmetric and asymmetric dimethylated arginine (DMA) are presented. (PMID:22101937)
• The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively. (PMID:22363433)
• The results show that SMNDC1 mRNA 5’-UTR forms an intramolecular, parallel G quadruplex structure comprised of three G quartet planes, which is bound specifically by FMRP both in vitro and in mouse brain lysates. (PMID:28612854)
• Low SMNDC1 expression is associated with lung cancer. (PMID:31911676)
• Interactome analysis of the Tudor domain-containing protein SPF30 which associates with the MTR4-exosome RNA-decay machinery under the regulation of AAA-ATPase NVL2. (PMID:33422691)
• SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. (PMID:36044849)
• An autoregulatory poison exon in Smndc1 is conserved across kingdoms and influences organism growth. (PMID:39150991)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	smndc1	ENSDARG00000056235
mus_musculus	Smndc1	ENSMUSG00000025024
rattus_norvegicus	Smndc1	ENSRNOG00000014833
drosophila_melanogaster	Spf30	FBGN0039977
caenorhabditis_elegans		WBGENE00004891

Paralogs (2): SMN1 (ENSG00000172062), SMN2 (ENSG00000205571)

Protein

Protein identifiers

Survival of motor neuron-related-splicing factor 30 — O75940 (reviewed: O75940)

Alternative names: 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1

All UniProt accessions (3): O75940, A0A6Q8PFX6, A0A6Q8PG47

UniProt curated annotations — full annotation on UniProt →

Function. Involved in spliceosome assembly.

Subunit / interactions. Associates with spliceosomes. Associates with U4/U5/U6 tri-snRNP and with U2 snRNP. Interacts (via Tudor domain) with SNRPD3 (via C-terminus); the interaction is direct.

Subcellular location. Nucleus speckle. Nucleus. Cajal body.

Tissue specificity. Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.

Domain organisation. The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.

Similarity. Belongs to the SMN family.

RefSeq proteins (1): NP_005862* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002999	Tudor	Domain
IPR010304	SMN_Tudor	Domain

Pfam: PF06003

UniProt features (15 total): strand 4, turn 3, modified residue 2, chain 1, domain 1, helix 1, short sequence motif 1, mutagenesis site 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
4A4F	SOLUTION NMR
4A4H	SOLUTION NMR
8POI	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75940-F1	77.86	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 201, 219

Mutagenesis-validated functional residues (1):

Position	Phenotype
108–117	increases binding to substrate containing dimethylated arginine.

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-72163	mRNA Splicing - Major Pathway
R-HSA-9770562	mRNA Polyadenylation
R-HSA-9918481	Dengue Virus-Host Interactions
R-HSA-9943411	CHD1 and CHD2 subfamily
R-HSA-72172	mRNA Splicing
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 199 (showing top): BORCZUK_MALIGNANT_MESOTHELIOMA_UP, MORF_RAD21, MORF_HDAC2, PUJANA_CHEK2_PCC_NETWORK, MORF_TERF1, WEI_MYCN_TARGETS_WITH_E_BOX, MUELLER_PLURINET, MORF_RAF1, INAMURA_LUNG_CANCER_SCC_SUBTYPES_UP, REACTOME_MRNA_3_END_PROCESSING, REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA, GOBP_RNA_SPLICING, REACTOME_MRNA_SPLICING, SCHLOSSER_SERUM_RESPONSE_DN, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP

GO Biological Process (4): RNA splicing, via transesterification reactions (GO:0000375), mRNA processing (GO:0006397), apoptotic process (GO:0006915), RNA splicing (GO:0008380)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), cytoplasm (GO:0005737), Cajal body (GO:0015030), nuclear speck (GO:0016607)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
mRNA Splicing	1
mRNA 3’-end processing	1
Dengue Virus Infection	1
CHD chromatin remodelers	1
Processing of Capped Intron-Containing Pre-mRNA	1
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
cellular anatomical structure	2
nuclear ribonucleoprotein granule	2
RNA splicing	1
mRNA metabolic process	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
nucleic acid binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1462 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SMNDC1	TDRD3	Q9H7E2	673
SMNDC1	TCERG1	O14776	629
SMNDC1	U2AF1	Q01081	543
SMNDC1	PI15	O43692	515
SMNDC1	EFTUD2	Q15029	515
SMNDC1	PCF11	O94913	513
SMNDC1	SND1	Q7KZF4	508
SMNDC1	SNRPA1	P09661	504
SMNDC1	CSTF2	P33240	497
SMNDC1	PRPF8	Q6P2Q9	494
SMNDC1	SMN1	Q16637	491
SMNDC1	FIP1L1	Q6UN15	483
SMNDC1	SF3B4	Q15427	464
SMNDC1	DDX46	Q7L014	455
SMNDC1	PHF19	Q5T6S3	423

IntAct

68 interactions, top by confidence:

A	B	Type	Score
SMNDC1	SF3B1	psi-mi:“MI:0914”(association)	0.790
SF3B1	SAP18	psi-mi:“MI:0914”(association)	0.640
SMNDC1	PRPF3	psi-mi:“MI:0915”(physical association)	0.620
PRPF3	SMNDC1	psi-mi:“MI:0915”(physical association)	0.620
SMNDC1	SF3A2	psi-mi:“MI:0915”(physical association)	0.560
SMNDC1	NCL	psi-mi:“MI:0915”(physical association)	0.540
U2SURP	SMNDC1	psi-mi:“MI:0914”(association)	0.480
SMNDC1	U2SURP	psi-mi:“MI:0914”(association)	0.480
KPNB1	SMNDC1	psi-mi:“MI:0915”(physical association)	0.400
SNRPB	SMNDC1	psi-mi:“MI:0915”(physical association)	0.400
LDHD	METTL8	psi-mi:“MI:0914”(association)	0.350
NCBP3	RSL1D1	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
ARHGEF19	NUP42	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
LIN28A	MEX3A	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
ATG13	ENAH	psi-mi:“MI:0914”(association)	0.350
PRP4K	YTHDC1	psi-mi:“MI:0914”(association)	0.350
RBM39	RPS3A	psi-mi:“MI:0914”(association)	0.350
SF3A1	HSPA8	psi-mi:“MI:0914”(association)	0.350
SNRPA	DDX39A	psi-mi:“MI:0914”(association)	0.350
SNRPB	DDX39A	psi-mi:“MI:0914”(association)	0.350
SNRPC	DDX39A	psi-mi:“MI:0914”(association)	0.350
SNRPF	SUPT5H	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350
SLC14A2	SMCHD1	psi-mi:“MI:0914”(association)	0.350
SLC26A11	CNOT1	psi-mi:“MI:0914”(association)	0.350
SF3B1	RBM10	psi-mi:“MI:0914”(association)	0.350

BioGRID (157): SMNDC1 (Affinity Capture-RNA), NFATC2IP (Co-fractionation), RACGAP1 (Co-fractionation), RBM42 (Co-fractionation), RRBP1 (Co-fractionation), SMNDC1 (Co-fractionation), SMNDC1 (Proximity Label-MS), SMNDC1 (Affinity Capture-MS), SF3B3 (Affinity Capture-MS), SF3B2 (Affinity Capture-MS), RPL3 (Affinity Capture-MS), TSR1 (Affinity Capture-MS), EWSR1 (Affinity Capture-MS), CDK5RAP3 (Affinity Capture-MS), FDFT1 (Affinity Capture-MS)

ESM2 similar proteins: A5D989, A6QLI8, A8B976, B4NSP6, C4Y9X0, C5DJL0, O02108, O75940, O82486, P0CP06, P0CP07, P29083, P29692, P29693, P32192, P34827, P35600, P53787, P57776, P82804, Q09689, Q22918, Q24276, Q40682, Q45FF9, Q4P3H6, Q4QQU6, Q4R3D4, Q5AX35, Q5BFH3, Q5R591, Q5R8H5, Q68FR9, Q6C3L4, Q6DEY1, Q6NQK0, Q6NWJ4, Q717R8, Q7RUX3, Q7ZV80

Diamond homologs: O02771, O18870, O35876, O75940, P97801, Q16637, Q3T045, Q4QQU6, Q4R4F8, Q5R591, Q5RE18, Q66HC1, Q6DEY1, Q7ZV80, Q8BGT7, Q8HYB8, Q9W6S8, Q2HJG4, Q6NYG6, Q91W18, Q9VV74, Q5ZMS6, Q6NRP6, Q6P1U3, Q7SXW2, A4IF98, Q58EK5, Q5ZHV8, Q7ZVM9, Q9H7E2, Q9H9A7, P91399, Q9D4G9, A9CPT4, A1XD93, A1XD94, A1XD95, A1XD97, A4UMC5, A4UMC6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 79 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing - Minor Pathway	8	30.9×	6e-09
mRNA Splicing	15	28.4×	2e-16
mRNA Polyadenylation	17	25.8×	7e-18
Processing of Capped Intron-Containing Pre-mRNA	17	24.1×	2e-17
CHD1 and CHD2 subfamily	12	22.5×	7e-12
mRNA Splicing - Major Pathway	21	19.8×	8e-20
Metabolism of RNA	19	13.7×	3e-15
Dengue Virus-Host Interactions	14	11.0×	9e-10

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	11	94.0×	1e-17
RNA splicing, via transesterification reactions	5	42.8×	9e-06
mRNA splicing, via spliceosome	20	25.1×	2e-20
RNA splicing	14	16.9×	1e-11
mRNA processing	11	11.9×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	12
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

931 predictions. Top by Δscore:

Variant	Effect	Δscore
10:110294285:TACC:T	acceptor_loss	1.0000
10:110294286:ACC:A	acceptor_loss	1.0000
10:110294289:T:A	acceptor_loss	1.0000
10:110295224:CAA:C	donor_loss	1.0000
10:110295227:C:A	donor_loss	1.0000
10:110295227:CCTGG:C	donor_gain	1.0000
10:110295377:CTTTT:C	acceptor_gain	1.0000
10:110295378:TTTT:T	acceptor_gain	1.0000
10:110295379:TTT:T	acceptor_gain	1.0000
10:110295380:TT:T	acceptor_gain	1.0000
10:110295382:C:CC	acceptor_gain	1.0000
10:110295382:CT:C	acceptor_loss	1.0000
10:110295385:C:CT	acceptor_gain	1.0000
10:110295386:A:AC	acceptor_gain	1.0000
10:110295386:A:C	acceptor_gain	1.0000
10:110297562:CTTA:C	donor_gain	1.0000
10:110297565:A:AC	donor_gain	1.0000
10:110297566:C:CT	donor_gain	1.0000
10:110297566:CT:C	donor_gain	1.0000
10:110297566:CTT:C	donor_gain	1.0000
10:110297566:CTTT:C	donor_gain	1.0000
10:110297566:CTTTG:C	donor_gain	1.0000
10:110297568:TTG:T	donor_gain	1.0000
10:110297724:AACAC:A	acceptor_gain	1.0000
10:110297725:ACAC:A	acceptor_gain	1.0000
10:110297726:CAC:C	acceptor_gain	1.0000
10:110297726:CACC:C	acceptor_gain	1.0000
10:110297727:AC:A	acceptor_gain	1.0000
10:110297728:CC:C	acceptor_gain	1.0000
10:110297729:C:CC	acceptor_gain	1.0000

AlphaMissense

1570 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:110294205:A:G	M221T	1.000
10:110294226:C:T	C214Y	1.000
10:110294227:A:G	C214R	1.000
10:110294232:C:T	G212E	1.000
10:110294233:C:G	G212R	1.000
10:110294233:C:T	G212R	1.000
10:110294238:C:T	G210E	1.000
10:110294239:C:G	G210R	1.000
10:110294239:C:T	G210R	1.000
10:110294247:C:T	G207D	1.000
10:110294248:C:G	G207R	1.000
10:110294270:A:C	F199L	1.000
10:110294270:A:T	F199L	1.000
10:110294271:A:C	F199C	1.000
10:110294271:A:G	F199S	1.000
10:110294272:A:C	F199V	1.000
10:110294272:A:G	F199L	1.000
10:110294272:A:T	F199I	1.000
10:110294274:A:G	I198T	1.000
10:110294274:A:T	I198N	1.000
10:110294276:A:C	S197R	1.000
10:110294276:A:T	S197R	1.000
10:110294278:T:G	S197R	1.000
10:110295264:G:C	F181L	1.000
10:110295264:G:T	F181L	1.000
10:110295265:A:C	F181C	1.000
10:110295265:A:G	F181S	1.000
10:110295266:A:G	F181L	1.000
10:110295273:C:A	W178C	1.000
10:110295273:C:G	W178C	1.000

dbSNP variants (sampled 300 via entrez): RS1000033651 (10:110301965 A>C), RS1000536634 (10:110296529 A>G), RS1000644394 (10:110303041 C>A,T), RS1001060076 (10:110298353 CCATT>C), RS1001086216 (10:110303837 G>A,T), RS1001243681 (10:110291569 C>A,G), RS1001484272 (10:110304674 T>C), RS1001794812 (10:110293302 C>A,T), RS1001879558 (10:110303056 T>A,C), RS1001910858 (10:110292955 G>A,C,T), RS1001989542 (10:110295973 A>G), RS1002081990 (10:110305645 T>C), RS1002138160 (10:110299546 G>A), RS1002242222 (10:110305338 T>G), RS1002538968 (10:110299655 T>A,C,G)

Disease associations

OMIM: gene MIM:603519 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002094_7	Crohn’s disease	2.000000e-10
GCST010002_224	Refractive error	2.000000e-14

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105959 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	affects expression, decreases methylation	2
Cyclosporine	increases expression	2
GSK-J4	increases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
sodium arsenite	increases expression	1
coumarin	increases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
fenpyroximate	decreases expression	1
abrine	increases expression	1
pyrachlostrobin	decreases expression	1
jinfukang	decreases expression, affects cotreatment	1
picoxystrobin	decreases expression	1
Arsenic	affects methylation	1
Caffeine	increases phosphorylation	1
Cisplatin	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ivermectin	decreases expression	1
Ozone	affects expression, increases abundance	1
Phenobarbital	affects expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Thiram	increases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	increases expression	1
tert-Butylhydroperoxide	increases expression	1

ChEMBL screening assays

9 unique, capped per target: 9 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4012565	Binding	Binding affinity to survival of motor neuron-related-splicing factor 30 in human INA-6 cells after 3 hrs by nanoLC-MS/MS method	Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.