SMTN

Summary

SMTN (smoothelin, HGNC:11126) is a protein-coding gene on chromosome 22q12.2, encoding Smoothelin (P53814). Structural protein of the cytoskeleton.

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Source: NCBI Gene 6525 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 222 total
• MANE Select transcript: NM_134269

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11126
Approved symbol	SMTN
Name	smoothelin
Location	22q12.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000183963
Ensembl biotype	protein_coding
OMIM	602127
Entrez	6525

Gene structure

Transcript identifiers

Ensembl transcripts: 50 — 41 protein_coding, 7 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000333137, ENST00000347557, ENST00000358743, ENST00000404574, ENST00000416786, ENST00000422839, ENST00000426927, ENST00000431481, ENST00000432777, ENST00000438223, ENST00000440425, ENST00000455608, ENST00000460658, ENST00000466272, ENST00000472911, ENST00000475548, ENST00000482444, ENST00000489337, ENST00000493335, ENST00000497697, ENST00000504335, ENST00000612341, ENST00000619644, ENST00000624247, ENST00000897095, ENST00000897096, ENST00000897097, ENST00000897098, ENST00000897099, ENST00000897100, ENST00000897101, ENST00000897102, ENST00000897103, ENST00000897104, ENST00000897105, ENST00000897106, ENST00000897107, ENST00000897108, ENST00000951807, ENST00000951808, ENST00000951809, ENST00000951810, ENST00000951811, ENST00000951812, ENST00000951813, ENST00000951814, ENST00000951815, ENST00000951816, ENST00000951817, ENST00000951818

RefSeq mRNA: 16 — MANE Select: NM_134269 NM_001207017, NM_001207018, NM_001382638, NM_001382639, NM_001382640, NM_001382641, NM_001382642, NM_001382643, NM_001382644, NM_001382645, NM_001382646, NM_001382647, NM_001382648, NM_006932, NM_134269, NM_134270

CCDS: CCDS13886, CCDS13887, CCDS13888, CCDS74845, CCDS74846

Canonical transcript exons

ENST00000333137 — 21 exons

Exon	Start	End
ENSE00001675209	31088513	31088606
ENSE00003495028	31087965	31088113
ENSE00003495156	31104316	31104624
ENSE00003542263	31099062	31099179
ENSE00003624755	31083179	31083309
ENSE00003997936	31096998	31097060
ENSE00003997937	31097269	31097338
ENSE00003997938	31095303	31095455
ENSE00003997939	31091675	31091847
ENSE00003997940	31100885	31101049
ENSE00003997942	31081318	31081456
ENSE00003997943	31090961	31091482
ENSE00003997944	31090108	31090180
ENSE00003997945	31088699	31088777
ENSE00003997948	31096733	31096897
ENSE00003997949	31098667	31098840
ENSE00003997950	31088872	31088969
ENSE00003997951	31099745	31099896
ENSE00003997952	31090808	31090879
ENSE00003997953	31095534	31095609
ENSE00003997954	31089699	31090019

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 99.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.0581 / max 1400.8263, expressed in 1680 samples.

FANTOM5 promoters (18 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191736	24.1321	1661
191742	2.9288	51
191735	1.1033	225
191751	0.7482	99
191745	0.3665	188
191739	0.1762	70
191750	0.1130	32
191743	0.0963	30
191737	0.0930	33
191749	0.0603	32

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus muscularis layer	UBERON:0035833	99.74	gold quality
lower esophagus	UBERON:0013473	99.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.65	gold quality
mucosa of stomach	UBERON:0001199	99.62	gold quality
popliteal artery	UBERON:0002250	99.56	gold quality
tibial artery	UBERON:0007610	99.56	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.56	gold quality
aorta	UBERON:0000947	99.39	gold quality
body of uterus	UBERON:0009853	99.39	gold quality
apex of heart	UBERON:0002098	99.26	gold quality
left uterine tube	UBERON:0001303	99.25	gold quality
descending thoracic aorta	UBERON:0002345	99.25	gold quality
ascending aorta	UBERON:0001496	99.22	gold quality
thoracic aorta	UBERON:0001515	99.22	gold quality
right coronary artery	UBERON:0001625	99.21	gold quality
lower esophagus mucosa	UBERON:0035834	99.17	gold quality
sural nerve	UBERON:0015488	98.91	gold quality
left coronary artery	UBERON:0001626	98.83	gold quality
tibial nerve	UBERON:0001323	98.82	gold quality
coronary artery	UBERON:0001621	98.50	gold quality
right atrium auricular region	UBERON:0006631	98.35	gold quality
endocervix	UBERON:0000458	98.12	gold quality
myometrium	UBERON:0001296	98.05	gold quality
saphenous vein	UBERON:0007318	98.03	gold quality
colonic epithelium	UBERON:0000397	97.94	gold quality
fundus of stomach	UBERON:0001160	97.61	gold quality
heart left ventricle	UBERON:0002084	97.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.40	gold quality
cardiac ventricle	UBERON:0002082	97.39	gold quality
cardiac atrium	UBERON:0002081	97.37	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	62.52
E-MTAB-6678	yes	26.89
E-MTAB-7316	yes	24.68
E-MTAB-8410	yes	22.82
E-CURD-112	yes	11.01
E-HCAD-11	yes	9.69
E-ANND-3	yes	8.52
E-MTAB-9067	yes	7.71

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HEY2, HEYL, NOTCH1, RBPJ

miRNA regulators (miRDB)

14 targeting SMTN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-4472	99.56	66.08	1478
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-6795-5P	98.52	68.51	1277
HSA-MIR-299-3P	97.73	66.67	773
HSA-MIR-1237-5P	95.38	62.21	451
HSA-MIR-4488	95.38	62.00	443
HSA-MIR-4697-5P	95.38	61.72	457

Literature-anchored findings (GeneRIF, showing 18)

• immunohistochemistry, using a panel composed of desmin, smoothelin, and vimentin, may be potentially useful for staging of bladder carcinoma. (PMID:19252475)
• Suggest that the extent and pattern of smoothelin expression may help differentiate between benign and malignant mesenchymal tumors of the GI tract. (PMID:19950405)
• Confirm the relatively distinct staining pattern of smoothelin between muscularis mucosae and muscularis propria and suggest caution when using smoothelin immunohistochemistry as a diagnostic tool. (PMID:20154589)
• Smoothelin immunohistochemistry has diagnostic utility in the evaluation of muscularis propria invasion in urothelial carcinoma. (PMID:20636795)
• The expression of smoothelin was analysed immunohistochemically in comparison with alpha-smooth muscle actin (alpha-SMA) in specimens from colon, stomach and oesophagus (n = 107). (PMID:20716166)
• Immunohistochemistry for smoothelin identifies differential staining between the neomuscularis mucosa and the true muscularis mucosa in Barrett’s esophagus. (PMID:21164287)
• We report the first study of smoothelin expression in normal skin (PMID:21472682)
• Smoothelin immunoreactivity in bladder diverticula confirms limited nature of smoothelin expression in muscularis mucosae and represents useful ancillary technique in proper histopathologic evaluation of diverticular and nondiverticular bladder carcinoma (PMID:21683983)
• Phenotypic expression of alpha-smooth muscle actin, smooth muscle myosin heavy chain 2, and smoothelin were significantly decreased in the dissected media, whereas that of osteopontin was elevated. (PMID:22960022)
• for the Japanese women, the frequency of the C-T-T-G haplotype (established by rs5997872, rs56095120, rs9621187, and rs10304) was significantly higher in the myocardial infarction group than in the control group (PMID:22963604)
• Smoothelin haplotype constructed using rs5997872, rs56095120, rs9621187 and rs10304 was a useful genetic marker of cerebral infarction in Japanese men. (PMID:23033319)
• lower level of expresseion in colonic inertia patients (PMID:23060305)
• There is an association between essential hypertension and the SMTN gene. (PMID:23121329)
• The objective of the following study was to record the specificity and sensitivity of alpha5(IV) loss, smoothelin expression and PLAP expression as markers of gastrointestinal smooth muscle neoplasms (PMID:24043717)
• During development of advanced liver fibrosis, a subpopulation of myofibroblasts expressing smoothelin may be derived from vascular smooth muscle cells. (PMID:24409061)
• Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. (PMID:24551305)
• Smoothelin is a specific marker for smooth muscle cells with contractile capacity which has not been widely studied in glomus lesions. in this study, glomic cells showed cytoplasmic positivity for smoothelin. Smoothelin expression in glomic cells indicates that they are contractile smooth muscle cells, and thus its role in routine diagnosis should be considered. (PMID:27184662)
• Analysis of Tumor Depth Invasion With Anti-Smoothelin Antibody in Equivocal Transurethral Resection of Urinary Bladder Tumor Surgical Specimens. (PMID:33090031)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Smtn	ENSMUSG00000020439
rattus_norvegicus	Smtn	ENSRNOG00000019451

Protein

Protein identifiers

Smoothelin — P53814 (reviewed: P53814)

All UniProt accessions (12): P53814, A0A087WVP4, A0A087X1R1, A0A096LNK9, B5MCI0, C9JBH9, C9JGQ0, C9JP19, C9JQZ8, C9JV14, C9JYU8, H7C372

UniProt curated annotations — full annotation on UniProt →

Function. Structural protein of the cytoskeleton.

Subcellular location. Cytoplasm. Cytoskeleton.

Tissue specificity. Smooth muscle; contractile or vascular (for the long form).

Miscellaneous. Produced by alternative promoter usage.

Similarity. Belongs to the smoothelin family.

Isoforms (4)

UniProt ID	Names	Canonical?
P53814-1	B, Long, B1, L1	yes
P53814-2	A, Short
P53814-5	B2, L2
P53814-6	B3

RefSeq proteins (16): NP_001193946, NP_001193947, NP_001369567, NP_001369568, NP_001369569, NP_001369570, NP_001369571, NP_001369572, NP_001369573, NP_001369574, NP_001369575, NP_001369576, NP_001369577, NP_008863, NP_599031, NP_599032 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001715	CH_dom	Domain
IPR022189	SMTN	Domain
IPR036872	CH_dom_sf	Homologous_superfamily
IPR050540	F-actin_Monoox_Mical	Family

Pfam: PF00307, PF12510

UniProt features (54 total): modified residue 15, compositionally biased region 12, sequence variant 7, helix 5, region of interest 3, splice variant 3, turn 2, coiled-coil region 2, initiator methionine 1, chain 1, domain 1, sequence conflict 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2D87	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P53814-F1	60.38	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (15): 2, 299, 301, 304, 341, 351, 357, 360, 373, 503, 514, 523, 576, 729, 792

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 181 (showing top): MODULE_52, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, SP3_Q3, AREB6_03, TOMLINS_PROSTATE_CANCER_DN, CHANDRAN_METASTASIS_DN, BILD_HRAS_ONCOGENIC_SIGNATURE, MODULE_118, AMIT_EGF_RESPONSE_480_MCF10A, RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT, GOBP_MUSCLE_CONTRACTION, KOYAMA_SEMA3B_TARGETS_UP, FISCHER_G2_M_CELL_CYCLE

GO Biological Process (2): smooth muscle contraction (GO:0006939), muscle organ development (GO:0007517)

GO Molecular Function (3): actin binding (GO:0003779), structural constituent of muscle (GO:0008307), protein binding (GO:0005515)

GO Cellular Component (3): cytoskeleton (GO:0005856), actin cytoskeleton (GO:0015629), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
muscle contraction	1
animal organ development	1
muscle structure development	1
cytoskeletal protein binding	1
structural molecule activity	1
binding	1
intracellular membraneless organelle	1
cytoskeleton	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

918 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
SMTN	MYH11	P35749	780
SMTN	HIRA	P54198	763
SMTN	TAGLN	Q01995	763
SMTN	CNN1	P51911	759
SMTN	MYOCD	Q8IZQ8	682
SMTN	CALD1	Q05682	620
SMTN	FLNA	P21333	591
SMTN	ACTA2	P03996	576
SMTN	ELN	P15502	559
SMTN	TAGLN3	Q9UI15	544
SMTN	TAGLN2	P37802	518
SMTN	FLNC	Q14315	507
SMTN	PPP1R12A	O14974	507
SMTN	FLNB	O75369	503
SMTN	DMD	P11532	498

IntAct

68 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
HRAS	RGL2	psi-mi:“MI:0914”(association)	0.660
PIP	TBKBP1	psi-mi:“MI:0914”(association)	0.530
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
rep	ACTN4	psi-mi:“MI:0914”(association)	0.480
SMTN	NCL	psi-mi:“MI:0915”(physical association)	0.400
BRMS1	SMTN	psi-mi:“MI:0915”(physical association)	0.370
ALG3	SMTN	psi-mi:“MI:0915”(physical association)	0.370
RIPK4	VWA8	psi-mi:“MI:0914”(association)	0.350
PB1	HAX1	psi-mi:“MI:0914”(association)	0.350
PB1	IPO5	psi-mi:“MI:0914”(association)	0.350
PB1	ESYT2	psi-mi:“MI:0914”(association)	0.350
PB2	HAX1	psi-mi:“MI:0914”(association)	0.350
PB2	ESYT2	psi-mi:“MI:0914”(association)	0.350
PB2	SEC16A	psi-mi:“MI:0914”(association)	0.350
NS1	HAX1	psi-mi:“MI:0914”(association)	0.350

BioGRID (47): SMTN (Affinity Capture-RNA), SMTN (Proximity Label-MS), SMTN (Affinity Capture-MS), SMTN (Affinity Capture-MS), SMTN (Affinity Capture-RNA), SMTN (Affinity Capture-MS), SMTN (Affinity Capture-MS), SMTN (Affinity Capture-MS), SMTN (Proximity Label-MS), SMTN (Proximity Label-MS), SMTN (Co-localization), SMTN (Affinity Capture-RNA), SMTN (Affinity Capture-MS), SMTN (Affinity Capture-MS), SMTN (Two-hybrid)

ESM2 similar proteins: A0A0U1RR37, A1L170, A1L1I3, A1L260, A2AMM0, A4IFJ0, B5G1P1, D3ZQL6, E7F5E1, G5BQH4, O08919, O54724, O60237, O75420, P06759, P33622, P53814, P85125, Q2KI85, Q2TAL5, Q3T044, Q3UMT1, Q4RTJ5, Q4V882, Q5I1X5, Q5U2R6, Q63312, Q6NZI2, Q75AS0, Q80VC9, Q8BG95, Q8BGT6, Q8C0J6, Q8CI12, Q8IV56, Q8K382, Q8N3F8, Q8TEH3, Q8WUF5, Q91VJ2

Diamond homologs: A5D7D1, A8MU46, D3ZEN0, D3ZHV2, D3ZQL6, D4A1F2, E1BBG2, E7F9T0, F1MF74, F1QH17, F1QWK4, F1RA39, F6QZ15, G3MWR8, G3V7L1, L7UZ85, M9MRD1, O13728, O15020, O43707, O76329, O88990, O94851, O97592, P05094, P05095, P11277, P11530, P11531, P11532, P11533, P12814, P15508, P18091, P20111, P30427, P35609, P46939, P53814, P57780

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

222 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	184
Likely benign	11
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

3599 predictions. Top by Δscore:

Variant	Effect	Δscore
22:31083306:GCTG:G	donor_gain	1.0000
22:31083307:CTGG:C	donor_loss	1.0000
22:31083308:TGG:T	donor_loss	1.0000
22:31083309:GGTAA:G	donor_loss	1.0000
22:31083310:G:GG	donor_gain	1.0000
22:31083310:G:T	donor_loss	1.0000
22:31083311:T:A	donor_loss	1.0000
22:31087960:T:A	acceptor_gain	1.0000
22:31087960:TGCA:T	acceptor_loss	1.0000
22:31087961:GCAG:G	acceptor_loss	1.0000
22:31087962:CA:C	acceptor_loss	1.0000
22:31087963:A:AG	acceptor_gain	1.0000
22:31087963:A:G	acceptor_loss	1.0000
22:31087963:AGCT:A	acceptor_gain	1.0000
22:31087963:AGCTG:A	acceptor_gain	1.0000
22:31087964:G:GA	acceptor_gain	1.0000
22:31087964:GC:G	acceptor_gain	1.0000
22:31087964:GCT:G	acceptor_gain	1.0000
22:31087964:GCTG:G	acceptor_gain	1.0000
22:31087964:GCTGG:G	acceptor_gain	1.0000
22:31088109:CTGCA:C	donor_gain	1.0000
22:31088110:TGCA:T	donor_gain	1.0000
22:31088111:GCA:G	donor_gain	1.0000
22:31088111:GCAG:G	donor_gain	1.0000
22:31088112:CA:C	donor_gain	1.0000
22:31088114:G:GG	donor_gain	1.0000
22:31088114:G:T	donor_loss	1.0000
22:31088116:G:GC	donor_loss	1.0000
22:31088117:A:AC	donor_loss	1.0000
22:31088118:G:C	donor_loss	1.0000

AlphaMissense

5865 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:31099142:T:C	L805P	1.000
22:31099145:T:C	L806P	1.000
22:31099150:T:A	W808R	1.000
22:31099150:T:C	W808R	1.000
22:31099152:G:C	W808C	1.000
22:31099152:G:T	W808C	1.000
22:31099155:T:G	C809W	1.000
22:31099749:T:A	V819D	1.000
22:31099764:T:C	F824S	1.000
22:31099775:T:A	W828R	1.000
22:31099775:T:C	W828R	1.000
22:31099777:G:C	W828C	1.000
22:31099777:G:T	W828C	1.000
22:31099784:G:T	G831W	1.000
22:31099785:G:A	G831E	1.000
22:31099785:G:T	G831V	1.000
22:31099794:T:C	F834S	1.000
22:31099803:T:C	L837P	1.000
22:31099883:T:C	F864L	1.000
22:31099884:T:C	F864S	1.000
22:31099885:C:A	F864L	1.000
22:31099885:C:G	F864L	1.000
22:31099130:T:A	I801N	0.999
22:31099134:G:C	K802N	0.999
22:31099134:G:T	K802N	0.999
22:31099142:T:A	L805Q	0.999
22:31099151:G:C	W808S	0.999
22:31099153:T:C	C809R	0.999
22:31099154:G:A	C809Y	0.999
22:31099157:G:C	R810P	0.999

dbSNP variants (sampled 300 via entrez): RS1000082660 (22:31094992 T>C), RS1000222471 (22:31086264 T>C), RS1000376412 (22:31066661 G>A), RS1000382273 (22:31092104 T>C), RS1000443748 (22:31086051 C>T), RS1000572900 (22:31072795 T>C), RS1000604607 (22:31097974 C>A), RS1000664775 (22:31078740 G>A,C), RS1000781986 (22:31078509 G>A), RS1000878417 (22:31084582 G>C), RS1000942217 (22:31104743 A>C,G), RS1000946316 (22:31090909 C>T), RS1000977145 (22:31090671 G>T), RS1001039381 (22:31081525 C>G), RS1001121233 (22:31077653 A>C)

Disease associations

OMIM: gene MIM:602127 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001958_23	Bulimia nervosa	2.000000e-06
GCST010135_20	Oily fish consumption	3.000000e-10
GCST010135_5	Oily fish consumption	1.000000e-15
GCST010140_12	Pork consumption	3.000000e-10
GCST010140_49	Pork consumption	1.000000e-15
GCST010142_11	Fish- and plant-related diet	1.000000e-11
GCST012226_842	Waist circumference adjusted for body mass index	1.000000e-08
GCST012231_19	A body shape index	2.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

62 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects binding, increases reaction, affects cotreatment, increases abundance, increases expression (+1 more)	7
Benzo(a)pyrene	increases expression, affects methylation, decreases expression	3
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, increases expression	2
Arsenic	affects cotreatment, increases abundance, increases expression, decreases expression	2
Quercetin	increases expression, decreases phosphorylation	2
Silicon Dioxide	increases expression	2
Smoke	decreases expression, increases expression	2
Cyclosporine	decreases expression, increases expression	2
Aflatoxin B1	affects expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
bufotalin	increases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
lead acetate	increases expression	1
methylparaben	increases expression	1
trimellitic anhydride	increases expression	1
afimoxifene	decreases expression, decreases reaction	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
cupric chloride	increases expression	1
coumarin	increases phosphorylation	1
methacrylaldehyde	increases abundance, affects cotreatment, increases oxidation	1
avobenzone	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
abrine	increases expression	1
eprenetapopt	affects expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TP72	HAP1 SMTN (-) 1	Cancer cell line	Male
CVCL_XT56	HAP1 SMTN (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.