SNAI3-AS1

Summary

SNAI3-AS1 (SNAI3 antisense RNA 1, HGNC:28327) is a long non-coding RNA gene on chromosome 16q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28327
Approved symbol	SNAI3-AS1
Name	SNAI3 antisense RNA 1
Location	16q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC23284
Ensembl gene	ENSG00000260630
Ensembl biotype	lncRNA
Entrez	197187
RNAcentral	URS000075EA24 — lncRNA, 942 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 38 lncRNA

ENST00000563261, ENST00000563475, ENST00000565633, ENST00000567997, ENST00000568633, ENST00000569786, ENST00000654033, ENST00000661622, ENST00000661704, ENST00000663493, ENST00000669434, ENST00000687428, ENST00000690987, ENST00000691208, ENST00000692040, ENST00000693195, ENST00000693611, ENST00000700805, ENST00000702003, ENST00000847142, ENST00000847143, ENST00000847144, ENST00000847145, ENST00000847146, ENST00000847147, ENST00000847148, ENST00000847149, ENST00000847150, ENST00000847151, ENST00000847152, ENST00000847153, ENST00000847154, ENST00000847155, ENST00000847156, ENST00000847157, ENST00000847158, ENST00000847159, ENST00000847160

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563261 — 4 exons

Exon	Start	End
ENSE00002072889	88671813	88672122
ENSE00002598318	88663298	88663400
ENSE00002618539	88671277	88671465
ENSE00002630574	88686791	88687282

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 85.71.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.1599 / max 75.2944, expressed in 1630 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155544	5.1599	1630

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	85.71	gold quality
anterior cingulate cortex	UBERON:0009835	85.02	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.91	gold quality
adrenal tissue	UBERON:0018303	81.60	gold quality
amygdala	UBERON:0001876	81.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.22	gold quality
apex of heart	UBERON:0002098	81.04	gold quality
prefrontal cortex	UBERON:0000451	79.86	gold quality
putamen	UBERON:0001874	79.33	gold quality
neocortex	UBERON:0001950	79.31	gold quality
caudate nucleus	UBERON:0001873	79.17	gold quality
frontal cortex	UBERON:0001870	78.52	gold quality
nucleus accumbens	UBERON:0001882	78.06	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.78	gold quality
cerebral cortex	UBERON:0000956	77.35	gold quality
right adrenal gland cortex	UBERON:0035827	76.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	76.63	gold quality
right adrenal gland	UBERON:0001233	76.55	gold quality
cortical plate	UBERON:0005343	76.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.20	gold quality
stromal cell of endometrium	CL:0002255	75.99	gold quality
hypothalamus	UBERON:0001898	75.86	gold quality
cerebellar hemisphere	UBERON:0002245	75.63	gold quality
forebrain	UBERON:0001890	75.59	gold quality
cerebellar cortex	UBERON:0002129	75.57	gold quality
Ammon’s horn	UBERON:0001954	75.56	gold quality
granulocyte	CL:0000094	74.98	gold quality
brain	UBERON:0000955	74.56	gold quality
muscle of leg	UBERON:0001383	74.46	gold quality
left adrenal gland	UBERON:0001234	74.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA SNAI3-AS1 promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the UPF1/Smad7 signalling pathway. (PMID:31264769)
• LncRNA SNAI3-AS1 promotes PEG10-mediated proliferation and metastasis via decoying of miR-27a-3p and miR-34a-5p in hepatocellular carcinoma. (PMID:32826862)
• Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m[6]A-dependent recognition of Nrf2 mRNA mediated by SND1. (PMID:37202791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.