SNAR-E

Summary

SNAR-E (small NF90 (ILF3) associated RNA E, HGNC:34325) is a gene on chromosome 19q13.32.

Predicted to be located in cytoplasm and nucleus.

Source: NCBI Gene 100170220 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34325
Approved symbol	SNAR-E
Name	small NF90 (ILF3) associated RNA E
Location	19q13.32
Locus type	RNA, misc
Status	Approved
Entrez	100170220
RNAcentral	URS00001510FE — ncRNA, 120 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The identify IR as the first known tyrosine kinase for Munc18c as in GLUT4 vesicle exocytosis, exemplifying a new model for the coordination of SNARE assembly and vesicle mobilization events in response to a single extracellular stimulus. (PMID:21444687)
• expressed in cytotoxic T lymphocytes (PMID:22120889)
• A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcriptional co-activator AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil domain-containing protein CCDC127. (PMID:26873636)
• Data show that three effectors LegC2 [Legionella eukaryotic-like gene C2)/YlfB (yeast lethal factor B), LegC3, and LegC7/YlfA] functionally mimic glutamine (Q)-SNARE proteins. (PMID:27436892)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000897263 (19:46830468 C>A), RS1000952343 (19:46830925 A>C), RS1002750166 (19:46832242 C>T), RS1003110090 (19:46832520 A>G,T), RS1003338214 (19:46830557 A>C), RS1004961631 (19:46830829 G>A), RS1007002760 (19:46832669 T>C), RS1007153650 (19:46832574 C>A,G,T), RS1007650721 (19:46832498 C>A,T), RS1007973113 (19:46832080 A>C), RS1008317509 (19:46830140 G>A), RS1008417161 (19:46831855 G>A,C), RS1008623239 (19:46831806 C>T), RS1012004770 (19:46832654 A>G), RS1012428884 (19:46830611 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-methyl-4-isothiazolin-3-one	increases expression	1
didecyldimethylammonium	decreases expression	1
Benzo(a)pyrene	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.