SNHG10

Summary

SNHG10 (small nucleolar RNA host gene 10, HGNC:27510) is a long non-coding RNA gene on chromosome 14q32.13.

This gene is small nucleolar RNA host gene 10 and represents a non-protein coding RNA. Alternatively spliced transcript variants have been found for this gene.

Source: NCBI Gene 283596 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27510
Approved symbol	SNHG10
Name	small nucleolar RNA host gene 10
Location	14q32.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ40557, NCRNA00063, LINC00063, TP53LC16
Ensembl gene	ENSG00000247092
Ensembl biotype	lncRNA
Entrez	283596
RNAcentral	URS000075DE81 — lncRNA, 1341 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 36 — 35 lncRNA, 1 retained_intron

ENST00000500370, ENST00000553559, ENST00000554169, ENST00000555866, ENST00000654925, ENST00000658932, ENST00000660378, ENST00000663212, ENST00000667310, ENST00000667668, ENST00000671157, ENST00000685307, ENST00000820093, ENST00000820094, ENST00000820095, ENST00000820096, ENST00000820097, ENST00000820098, ENST00000820099, ENST00000820100, ENST00000820101, ENST00000820102, ENST00000820103, ENST00000820104, ENST00000820105, ENST00000820106, ENST00000820107, ENST00000820108, ENST00000820109, ENST00000820110, ENST00000820111, ENST00000820112, ENST00000820113, ENST00000820114, ENST00000820115, ENST00000820116

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500370 — 2 exons

Exon	Start	End
ENSE00001965440	95534035	95534800
ENSE00002467569	95532297	95533061

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 94.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.0341 / max 215.0675, expressed in 1767 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144800	10.9335	1739
144798	2.3637	763
144801	0.7899	415
144797	0.3372	145
144794	0.3078	141
144796	0.1879	71
144795	0.1141	27

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	94.41	gold quality
bone marrow cell	CL:0002092	94.18	gold quality
right uterine tube	UBERON:0001302	92.36	gold quality
adenohypophysis	UBERON:0002196	89.19	gold quality
left testis	UBERON:0004533	87.93	gold quality
right testis	UBERON:0004534	87.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.43	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.41	gold quality
left ovary	UBERON:0002119	87.11	gold quality
cerebellar hemisphere	UBERON:0002245	86.95	gold quality
cerebellar cortex	UBERON:0002129	86.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.46	gold quality
right ovary	UBERON:0002118	85.51	gold quality
left lobe of thyroid gland	UBERON:0001120	85.26	gold quality
right lobe of thyroid gland	UBERON:0001119	85.24	gold quality
pituitary gland	UBERON:0000007	85.23	gold quality
mucosa of transverse colon	UBERON:0004991	85.05	gold quality
cerebellum	UBERON:0002037	84.54	gold quality
testis	UBERON:0000473	84.19	gold quality
left uterine tube	UBERON:0001303	83.64	gold quality
thyroid gland	UBERON:0002046	83.43	gold quality
body of uterus	UBERON:0009853	83.22	gold quality
gastrocnemius	UBERON:0001388	83.21	gold quality
left adrenal gland cortex	UBERON:0035825	83.10	gold quality
endocervix	UBERON:0000458	83.00	gold quality
right coronary artery	UBERON:0001625	82.82	gold quality
muscle of leg	UBERON:0001383	82.63	gold quality
tibial nerve	UBERON:0001323	82.42	gold quality
transverse colon	UBERON:0001157	82.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.01

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• LncRNA SNHG10 Facilitates Hepatocarcinogenesis and Metastasis by Modulating Its Homolog SCARNA13. (PMID:31101763)
• Long Noncoding RNA SNHG10 Sponges miR-543 to Upregulate Tumor Suppressive SIRT1 in Nonsmall Cell Lung Cancer. (PMID:32319822)
• SNHG10/DDX54/PBX3 Feedback Loop Contributes to Gastric Cancer Cell Growth. (PMID:32712782)
• LncRNA SNHG10 increases the methylation of miR-218 gene to promote glucose uptake and cell proliferation in osteosarcoma. (PMID:32843060)
• SNHG10 Promotes Cell Proliferation and Migration in Gastric Cancer by Targeting miR-495-3p/CTNNB1 Axis. (PMID:32920660)
• LncRNA SNHG10 is downregulated in non-small cell lung cancer and predicts poor survival. (PMID:33081752)
• Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm. (PMID:34456184)
• Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis. (PMID:34613933)
• LncRNA SNHG10 suppresses the development of doxorubicin resistance by downregulating miR-302b in triple-negative breast cancer. (PMID:35506202)
• The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury. (PMID:37884162)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.