SNHG11

Summary

SNHG11 (small nucleolar RNA host gene 11, HGNC:25046) is a long non-coding RNA gene on chromosome 20q11.23.

This gene is a member of the non-protein-coding multiple snoRNA host gene family. Two snoRNAs are derived from the introns of this host gene. Although many alternative splice variants have been observed, the gene is thought to have no protein-coding potential.

Source: NCBI Gene 128439 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25046
Approved symbol	SNHG11
Name	small nucleolar RNA host gene 11
Location	20q11.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00101
Ensembl gene	ENSG00000174365
Ensembl biotype	lncRNA
OMIM	619494
Entrez	128439
RNAcentral	URS000075E4A3 — lncRNA, 1101 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 106 — 100 lncRNA, 6 retained_intron

ENST00000359074, ENST00000400436, ENST00000418383, ENST00000420006, ENST00000421599, ENST00000432153, ENST00000434729, ENST00000437028, ENST00000440918, ENST00000442419, ENST00000444816, ENST00000449351, ENST00000453698, ENST00000457218, ENST00000483342, ENST00000656427, ENST00000656502, ENST00000656815, ENST00000656824, ENST00000657911, ENST00000658222, ENST00000659148, ENST00000659610, ENST00000660281, ENST00000660884, ENST00000661078, ENST00000661378, ENST00000661733, ENST00000663763, ENST00000666020, ENST00000666350, ENST00000666813, ENST00000667760, ENST00000669083, ENST00000669207, ENST00000669338, ENST00000669976, ENST00000670145, ENST00000670898, ENST00000688319, ENST00000689733, ENST00000689738, ENST00000691928, ENST00000692199, ENST00000692643, ENST00000693500, ENST00000701214, ENST00000701247, ENST00000701309, ENST00000701488, ENST00000701721, ENST00000701784, ENST00000702328, ENST00000724752, ENST00000724753, ENST00000724754, ENST00000724755, ENST00000724756, ENST00000724757, ENST00000724758, ENST00000724759, ENST00000724760, ENST00000724761, ENST00000724762, ENST00000724763, ENST00000724764, ENST00000724765, ENST00000724766, ENST00000724767, ENST00000724768, ENST00000724769, ENST00000724770, ENST00000724771, ENST00000724772, ENST00000724773, ENST00000724774, ENST00000724775, ENST00000724776, ENST00000724777, ENST00000724778, ENST00000724779, ENST00000724780, ENST00000724781, ENST00000724782, ENST00000724783, ENST00000724784, ENST00000724785, ENST00000724786, ENST00000724787, ENST00000724788, ENST00000724789, ENST00000724790, ENST00000724791, ENST00000724792, ENST00000724793, ENST00000724794, ENST00000724795, ENST00000724796, ENST00000724797, ENST00000724798, ENST00000724799, ENST00000724800, ENST00000724801, ENST00000724802, ENST00000724803, ENST00000724804

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000359074 — 5 exons

Exon	Start	End
ENSE00001196987	38450336	38450447
ENSE00001426480	38450533	38450921
ENSE00001426983	38448662	38448730
ENSE00001667290	38447466	38447623
ENSE00004047746	38446654	38446940

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 97.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.7997 / max 165.8884, expressed in 1806 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
184570	12.4097	1804
184571	0.3510	142
184572	0.0390	12

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.59	gold quality
pancreatic ductal cell	CL:0002079	89.93	silver quality
right lobe of liver	UBERON:0001114	87.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.96	gold quality
apex of heart	UBERON:0002098	86.23	gold quality
skin of leg	UBERON:0001511	85.88	gold quality
right testis	UBERON:0004534	85.69	gold quality
mucosa of transverse colon	UBERON:0004991	85.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.51	gold quality
left testis	UBERON:0004533	85.45	gold quality
metanephros cortex	UBERON:0010533	85.38	gold quality
right lobe of thyroid gland	UBERON:0001119	85.18	gold quality
ileal mucosa	UBERON:0000331	85.11	silver quality
skin of abdomen	UBERON:0001416	85.03	gold quality
left lobe of thyroid gland	UBERON:0001120	84.66	gold quality
tibial nerve	UBERON:0001323	84.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.35	gold quality
right uterine tube	UBERON:0001302	84.29	gold quality
thyroid gland	UBERON:0002046	83.89	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.87	gold quality
testis	UBERON:0000473	83.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.63	gold quality
prefrontal cortex	UBERON:0000451	83.53	gold quality
lower esophagus mucosa	UBERON:0035834	83.53	gold quality
mucosa of stomach	UBERON:0001199	83.52	gold quality
cerebellar hemisphere	UBERON:0002245	83.51	gold quality
prostate gland	UBERON:0002367	83.47	gold quality
right frontal lobe	UBERON:0002810	83.47	gold quality
cerebellar cortex	UBERON:0002129	83.42	gold quality
right adrenal gland cortex	UBERON:0035827	83.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer. (PMID:31633800)
• Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB. (PMID:32065238)
• Long non-coding RNA SNHG11 promotes cell proliferation, invasion and migration in glioma by targeting miR-154-5p. (PMID:32432753)
• SNHG11 promotes cell proliferation in colorectal cancer by forming a positive regulatory loop with c-Myc. (PMID:32439170)
• SNHG11 contributes to NSCLC cell growth and migration by targeting miR-485-5p/BSG axis. (PMID:32544782)
• lncRNA SNHG11 promotes the development of colorectal cancer by mediating miR-339-3p/SHOX2. (PMID:32683847)
• LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1alpha. (PMID:33060856)
• lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/beta-Catenin Pathway and Oncogenic Autophagy. (PMID:33068778)
• lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF1R expression and by sponging miR184. (PMID:34328198)
• Dexmedetomidine improves oxygen-glucose deprivation/reoxygenation (OGD/R) -induced neurological injury through regulating SNHG11/miR-324-3p/VEGFA axis. (PMID:34334080)
• Exosome-mediated lncRNA SNHG11 regulates angiogenesis in pancreatic carcinoma through miR-324-3p/VEGFA axis. (PMID:34519129)
• Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer. (PMID:35276744)
• LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis. (PMID:35324517)
• LncRNA SNHG11 accelerates the progression of lung adenocarcinoma via activating Notch pathways. (PMID:35487027)
• Long non-coding RNA SNHG11 regulates the Wnt/beta-catenin signaling pathway through rho/ROCK in trabecular meshwork cells. (PMID:36929360)
• SNHG11: A New Budding Star in Tumors and Inflammatory Diseases. (PMID:37165588)
• The function of long non-coding RNA SNHG11 and its working mechanism in triple-negative breast cancer. (PMID:37320865)
• The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome. (PMID:38409595)
• [LncRNA SNHG11 promotes malignant progression of colorectal cancer cells through the PI3K/Akt/mTOR signaling pathway]. (PMID:38462356)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.