SNHG12

Summary

SNHG12 (small nucleolar RNA host gene 12, HGNC:30062) is a long non-coding RNA gene on chromosome 1p35.3.

This gene produces a long RNA that is overexpressed in tumor cells. This RNA may promote tumorigenesis by acting as a sponge for microRNAs.

Source: NCBI Gene 85028 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30062
Approved symbol	SNHG12
Name	small nucleolar RNA host gene 12
Location	1p35.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	PNAS-123, LINC00100, ASLNC04080
Ensembl gene	ENSG00000197989
Ensembl biotype	lncRNA
Entrez	85028
RNAcentral	URS0000BC4513 — lncRNA, 777 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 16 lncRNA, 10 retained_intron

ENST00000461448, ENST00000461832, ENST00000464115, ENST00000464612, ENST00000470977, ENST00000474814, ENST00000475441, ENST00000481220, ENST00000481368, ENST00000483436, ENST00000488745, ENST00000531126, ENST00000648127, ENST00000648251, ENST00000648327, ENST00000650239, ENST00000650259, ENST00000692541, ENST00000693199, ENST00000775059, ENST00000775060, ENST00000775061, ENST00000775062, ENST00000775063, ENST00000775064, ENST00000775065

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000461448 — 4 exons

Exon	Start	End
ENSE00001415324	28581111	28581229
ENSE00001832422	28581590	28581857
ENSE00001874333	28578538	28578680
ENSE00001949031	28579533	28580646

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 99.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 73.3069 / max 3023.0419, expressed in 1818 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11359	73.3069	1818

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oviduct epithelium	UBERON:0004804	99.53	gold quality
epithelial cell of pancreas	CL:0000083	98.06	gold quality
pancreatic ductal cell	CL:0002079	97.73	gold quality
lower esophagus mucosa	UBERON:0035834	97.68	gold quality
tendon of biceps brachii	UBERON:0008188	97.02	gold quality
endothelial cell	CL:0000115	96.72	gold quality
buccal mucosa cell	CL:0002336	96.54	gold quality
cartilage tissue	UBERON:0002418	95.69	gold quality
left ovary	UBERON:0002119	95.55	gold quality
gingival epithelium	UBERON:0001949	95.50	gold quality
sural nerve	UBERON:0015488	95.23	gold quality
epithelium of nasopharynx	UBERON:0001951	94.98	gold quality
vagina	UBERON:0000996	94.91	gold quality
esophagus mucosa	UBERON:0002469	94.88	gold quality
upper arm skin	UBERON:0004263	94.78	gold quality
sperm	CL:0000019	94.71	gold quality
granulocyte	CL:0000094	94.71	gold quality
ovary	UBERON:0000992	94.70	gold quality
colonic epithelium	UBERON:0000397	94.69	gold quality
right ovary	UBERON:0002118	94.69	gold quality
minor salivary gland	UBERON:0001830	94.48	gold quality
right lung	UBERON:0002167	94.43	gold quality
spleen	UBERON:0002106	94.41	gold quality
amniotic fluid	UBERON:0000173	94.07	gold quality
ectocervix	UBERON:0012249	94.04	gold quality
ileal mucosa	UBERON:0000331	93.97	gold quality
mouth mucosa	UBERON:0003729	93.97	gold quality
mucosa of transverse colon	UBERON:0004991	93.97	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.94	gold quality
upper lobe of left lung	UBERON:0008952	93.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• These results suggested a potential function of ASLNC04080 in endometrial carcinoma genesis and progression (PMID:25695231)
• The lncRNA SNHG12 promotes cell proliferation and migration by upregulating AMOT gene expression in osteosarcoma cells in vivo and in vitro. (PMID:26486328)
• Results showed that SNHG12 was strongly overexpressed in hepatocellular carcinoma (HCC) tissues and significantly associated with clinicopathological variables and prognosis. There were direct interactions between miR-199a/b-5p and the binding site of SNHG12. SNHG12 functioned as an endogenous sponge for miR-199a/b-5p to regulate the expression of the NF-kappaB pathway. (PMID:28073380)
• High SNHG12 expression is associated with Nonsmall Cell Lung Cancer. (PMID:28872894)
• we found that SNHG12 was significantly upregulated in both osteosarcoma tissues and cell lines and osteosarcoma patients with high levels of SNHG12 tended to have a poor prognosis (PMID:29229388)
• The knockdown of SNHG12 expression suppressed cell proliferation and invasion by modulating miR-424-5p expression. (PMID:29533945)
• lncRNA SNHG12 may play an important role in tumorigenesis and may serve as a molecular target for the malignant gastric carcinoma and lncRNA SNHG12 acts as a sponge for microRNA-199a/b-5p to act on its downstream genes. (PMID:29565487)
• The SNHG12 expression is relatively high in PTC tissues and cells. In-vivo/in-vitro experiments prove that SNHG12 can promote the proliferation and metastasis of PTC cells through influencing the Wnt/beta-catenin signaling pathway. (PMID:29630517)
• RNA immunoprecipitation and RNA pull-down assays in glioma cell lines demonstrated that SNHG12 was associated with and was stabilized by Hu antigen R. Glioma patients with high levels of SNHG12 exhibited a reduced 5-year overall survival rate. (PMID:30015836)
• Data showed that SNHG12 expression was enhanced and high-expressed in the glioma tissue and cell lines, especially in the advanced clinical grade, and that SNHG12 harbored the complementary binding sites with miR-101-3p at 3’-UTR, acting as a miRNA ‘sponge’. Also, its Knockdown impaired the proliferation and migration of glioma cells in vitro. (PMID:30098431)
• Down-regulation of DUXAP8 and SNHG12 could inhibit bladder cancer cells proliferation in vitro. (PMID:30243082)
• SNHG12 promotes the progression of cervical cancer via modulating miR-125b/STAT3 axis (PMID:30246459)
• knockdown of SNHG12 suppressed nasopharyngeal carcinoma (NPC) cells proliferation, migration and invasion. Mechanistic investigations showed that knockdown of SNHG12 suppressed the activation of EMT and Notch-1 signal pathway. (PMID:30452404)
• c-Myc mediated upregulation of long noncoding RNA SNHG12 regulates proliferation and drug sensitivity in natural killer/T-cell lymphoma. (PMID:30825244)
• Long noncoding RNA SNHG12 promotes cell proliferation and activates Wnt/beta-catenin signaling in prostate cancer through sponging microRNA-195. (PMID:30945357)
• LncRNA SNHG12 accelerates the progression of ovarian cancer via absorbing miRNA-129 to upregulate SOX4. (PMID:30964158)
• RT-qPCR and Western blot showed that WWP1 was positively regulated by SNHG12 and negatively regulated by miR-129-5p at the mRNA level and protein level. Overexpression of WWP1 significantly increased proliferation and invasion of laryngeal cancer cells. (PMID:31348766)
• Long noncoding RNA small nucleolar RNA host gene 12 promotes papillary thyroid carcinoma cell growth and invasion by targeting miR-16-5p. (PMID:31355416)
• lncSNHG12 silencing inhibited OS metastasis and growth by targeting the miR-195-5p/IGF1R axis. (PMID:31743769)
• We identified that lncRNA SNHG12 and LINC00152 might act as independent indicators were associated with the occurrence and progression for PTC (PMID:31773972)
• Long noncoding RNA SNHG12 modulated by human papillomavirus 16 E6/E7 promotes cervical cancer progression via ERK/Slug pathway. (PMID:31943193)
• DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma. (PMID:32039732)
• Long noncoding RNA SNHG12 suppresses esophageal squamous cell carcinoma progression through competing endogenous RNA networks. (PMID:32086782)
• Long noncoding RNA SNHG12 induces proliferation, migration, epithelial-mesenchymal transition, and stemness of esophageal squamous cell carcinoma cells via post-transcriptional regulation of BMI1 and CTNNB1. (PMID:32239639)
• Long noncoding RNA SNHG12 promotes vascular smooth muscle cell proliferation and migration via regulating miR-199a-5p/HIF-1alpha. (PMID:32339345)
• Upregulation of SNHG12 accelerates cell proliferation, migration, invasion and restrain cell apoptosis in breast cancer by enhancing regulating SALL4 expression via sponging miR-15a-5p. (PMID:32386479)
• LncRNA SNHG12 contributes proliferation, invasion and epithelial-mesenchymal transition of pancreatic cancer cells by absorbing miRNA-320b. (PMID:32432698)
• SNHG12/miR-326/E2F1 feedback loop facilitates the progression of oral squamous cell carcinoma. (PMID:32506729)
• Long noncoding RNA SNHG12 promotes the proliferation, migration, and invasion of trophoblast cells by regulating the epithelial-mesenchymal transition and cell cycle. (PMID:32529873)
• Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinoma. (PMID:32641718)
• lncRNA small nucleolar RNA host gene 12 promotes renal cell carcinoma progression by modulating the miR200c5p/collagen type XI alpha1 chain pathway. (PMID:32901847)
• Long noncoding RNA SNHG12 regulates cell proliferation, invasion and migration in endometrial cancer by targeting miR4429. (PMID:32945395)
• SNHG12 inhibits oxygenglucose deprivationinduced neuronal apoptosis via the miR181a5p/NEGR1 axis. (PMID:33000228)
• Prognostic Value of Long Noncoding RNA SNHG12 in Various Carcinomas: A Meta-Analysis. (PMID:33294456)
• LncRNA SNHG12 alleviates hypertensive vascular endothelial injury through miR-25-3p/SIRT6 pathway. (PMID:33464650)
• LncRNA SNHG12 downregulates RAGE to attenuate hypoxia-reoxygenation-induced apoptosis in H9c2 cells. (PMID:33589923)
• LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p. (PMID:33774129)
• SNHG12 promotes carcinogenesis of human renal cell cancer via functioning as a competing endogenous RNA and sponging miR-30a-3p. (PMID:33787057)
• YY1-modulated long non-coding RNA SNHG12 promotes gastric cancer metastasis by activating the miR-218-5p/YWHAZ axis. (PMID:33994849)
• LncRNA SNHG12 regulates the miR-101-3p/CUL4B axis to mediate the proliferation, migration and invasion of non-small cell lung cancer. (PMID:34002487)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.