SNHG14

Summary

SNHG14 (small nucleolar RNA host gene 14, HGNC:37462) is a long non-coding RNA gene on chromosome 15q11.2.

This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined.

Source: NCBI Gene 104472715 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37462
Approved symbol	SNHG14
Name	small nucleolar RNA host gene 14
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00214, UBE3A-AS, UBE3A-ATS
Ensembl gene	ENSG00000224078
Ensembl biotype	lncRNA
OMIM	616259
Entrez	104472715
RNAcentral	URS0000ABD7E9 — lncRNA, 19263 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 158 — 156 lncRNA, 2 retained_intron

ENST00000414175, ENST00000424208, ENST00000424333, ENST00000441592, ENST00000447911, ENST00000452731, ENST00000453082, ENST00000546682, ENST00000547292, ENST00000549804, ENST00000551077, ENST00000551361, ENST00000551631, ENST00000551938, ENST00000552781, ENST00000553108, ENST00000553134, ENST00000553149, ENST00000554726, ENST00000557108, ENST00000580438, ENST00000604135, ENST00000626200, ENST00000640631, ENST00000652996, ENST00000653389, ENST00000653407, ENST00000653489, ENST00000654023, ENST00000654058, ENST00000654223, ENST00000654902, ENST00000654984, ENST00000655143, ENST00000655153, ENST00000655258, ENST00000655461, ENST00000655695, ENST00000655746, ENST00000655954, ENST00000655965, ENST00000655993, ENST00000656009, ENST00000656420, ENST00000656450, ENST00000656463, ENST00000656474, ENST00000656510, ENST00000656600, ENST00000656959, ENST00000657002, ENST00000657011, ENST00000657095, ENST00000657237, ENST00000657285, ENST00000657798, ENST00000657850, ENST00000658480, ENST00000658502, ENST00000658623, ENST00000658769, ENST00000658853, ENST00000658859, ENST00000659029, ENST00000659236, ENST00000660376, ENST00000660430, ENST00000660542, ENST00000660717, ENST00000660956, ENST00000661110, ENST00000661253, ENST00000661305, ENST00000661389, ENST00000661541, ENST00000661608, ENST00000661738, ENST00000661889, ENST00000661926, ENST00000662370, ENST00000662451, ENST00000662834, ENST00000663026, ENST00000663359, ENST00000663446, ENST00000663600, ENST00000663612, ENST00000663945, ENST00000663996, ENST00000664256, ENST00000664545, ENST00000664763, ENST00000665253, ENST00000665311, ENST00000665397, ENST00000665411, ENST00000665547, ENST00000665799, ENST00000665819, ENST00000665906, ENST00000665930, ENST00000665961, ENST00000666022, ENST00000666289, ENST00000666606, ENST00000666663, ENST00000666955, ENST00000667390, ENST00000667393, ENST00000667478, ENST00000667531, ENST00000667788, ENST00000667925, ENST00000668163, ENST00000668419, ENST00000668444, ENST00000668570, ENST00000668750, ENST00000668953, ENST00000669064, ENST00000669072, ENST00000669377, ENST00000669673, ENST00000669778, ENST00000669814, ENST00000669867, ENST00000669911, ENST00000669928, ENST00000669989, ENST00000670011, ENST00000670384, ENST00000670394, ENST00000670542, ENST00000670587, ENST00000670678, ENST00000670697, ENST00000671079, ENST00000671121, ENST00000671136, ENST00000671374, ENST00000671491, ENST00000671517, ENST00000725872, ENST00000725873, ENST00000725874, ENST00000760387, ENST00000760388, ENST00000760389, ENST00000760390, ENST00000760391, ENST00000760392, ENST00000760393, ENST00000760394, ENST00000760395, ENST00000760396, ENST00000760397, ENST00000760398, ENST00000817286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414175 — 5 exons

Exon	Start	End
ENSE00001623201	25189741	25189784
ENSE00001658786	25191717	25191762
ENSE00001664314	25193133	25193489
ENSE00001698277	25191240	25191350
ENSE00001790736	25189303	25189354

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 99.55.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1470 / max 217.0966, expressed in 319 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
207435	1.2710	563
145504	1.1470	319
145538	0.6067	197
145537	0.2026	87
145505	0.1744	86

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lateral nuclear group of thalamus	UBERON:0002736	99.55	gold quality
Brodmann (1909) area 23	UBERON:0013554	99.53	gold quality
pons	UBERON:0000988	99.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.13	gold quality
superior vestibular nucleus	UBERON:0007227	99.02	gold quality
cerebellar hemisphere	UBERON:0002245	98.91	gold quality
lateral globus pallidus	UBERON:0002476	98.90	gold quality
substantia nigra pars compacta	UBERON:0001965	98.83	gold quality
cerebellar cortex	UBERON:0002129	98.80	gold quality
endothelial cell	CL:0000115	98.74	gold quality
left lobe of thyroid gland	UBERON:0001120	98.72	gold quality
right lobe of thyroid gland	UBERON:0001119	98.71	gold quality
parietal lobe	UBERON:0001872	98.69	gold quality
thyroid gland	UBERON:0002046	98.65	gold quality
postcentral gyrus	UBERON:0002581	98.59	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.53	gold quality
corpus epididymis	UBERON:0004359	98.49	gold quality
nucleus accumbens	UBERON:0001882	98.47	gold quality
adenohypophysis	UBERON:0002196	98.43	gold quality
right frontal lobe	UBERON:0002810	98.38	gold quality
buccal mucosa cell	CL:0002336	98.35	gold quality
entorhinal cortex	UBERON:0002728	98.08	gold quality
pituitary gland	UBERON:0000007	98.04	gold quality
putamen	UBERON:0001874	98.03	gold quality
caput epididymis	UBERON:0004358	98.01	gold quality
middle temporal gyrus	UBERON:0002771	97.97	gold quality
caudate nucleus	UBERON:0001873	97.91	gold quality
superior frontal gyrus	UBERON:0002661	97.87	gold quality
adrenal tissue	UBERON:0018303	97.86	gold quality
medulla oblongata	UBERON:0001896	97.84	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	7390.98
E-GEOD-180759	yes	6067.84
E-HCAD-25	yes	5361.55
E-HCAD-30	no	5033.02
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The SNURF-SNRPN sense/UBE3A antisense transcription unit spans more than 460 kb. (PMID:11726556)
• Results show that UBE3A-ATS expression is not affected by loss of neither RBFOX1 nor RBFOX2 expression in iPSCs and neurons. (PMID:27146458)
• These data suggest that lncRNA SNHG14 promotes breast cancer tumorigenesis and trastuzumab resistance through regulating PABPC1 expression through H3K27 acetylation. Therefore, SNHG14 may serve as a novel diagnostic and therapeutic target for breast cancer patients. (PMID:30063126)
• SNHG14 was significantly upregulated in cervical cancer tissues and cells, and associated with the overall survival of cervical cancer patients. Moreover, knockdown of SNHG14 significantly inhibited cell proliferation, migration and invasion, and promoted cell apoptosis in cervical cancer. (PMID:30611620)
• SNHG14 was significantly downregulated in pancreatic cancer and could promote the cancer cell progression. MiR-101 could directly interact with SNHG14 and reverse its impact on cell progression. (PMID:30737032)
• showed that the lncSNHG14 overexpression accelerates proliferative potential and cell cycle progression of Bladder Cancer cells through absorbing miRNA-150-5p to degrade VAMP2 expression. (PMID:30779068)
• LncSNHG14 promotes ovarian cancer by targeting microRNA-125a-5p. (PMID:31081075)
• SNHG14 confers gefitinib resistance in non-small cell lung cancer by regulating miR-206-3p/ABCB1 pathway. (PMID:31121484)
• SNHG14 silencing promoted non-small cell lung cancer cell sensitivity to cisplatin. (PMID:31252267)
• SNHG14 serves as a facilitator in colorectal carcer through targeting EZH2-repressed EPHA7. (PMID:31273190)
• Role of extracellular LncRNA-SNHG14/miRNA-3940-5p/NAP12 mRNA in colorectal cancer. (PMID:31397210)
• SNHG14 promotes the tumorigenesis and metastasis of colorectal cancer through miR-32-5p/ski-oncogene-like SKIL axis. (PMID:31471872)
• LncRNA SNHG14 potentiates pancreatic cancer progression via modulation of annexin A2 expression by acting as a competing endogenous RNA for miR-613. (PMID:31513352)
• Upregulation of SNHG14 suppresses cell proliferation and metastasis of colorectal cancer by targeting miR-92b-3p. (PMID:31692034)
• Our research indicated that the novel axis of SNHG14/miR-186/ATG14 could play a vital role in regulating colorectal cancer (CRC) cell progression; this axis showed its clinical potential in regulating cisplatin resistance during CRC treatment. (PMID:31704614)
• Long noncoding RNA SNHG14 accelerates cell proliferation, migration, invasion and suppresses apoptosis in colorectal cancer cells by targeting miR-944/KRAS axis through PI3K/AKT pathway. (PMID:31799655)
• Downregulation of long noncoding RNA SNHG14 suppresses cell proliferation and invasion by regulating EZH2 in pancreatic ductal adenocarcinoma (PDAC). (PMID:31929143)
• Long noncoding RNA SNHG14 promotes osteosarcoma progression via miR-433-3p/FBXO22 axis. (PMID:31948764)
• Long noncoding RNA SNHG14 promotes malignancy of prostate cancer by regulating with miR-5590-3p/YY1 axis. (PMID:32432733)
• Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14. (PMID:32527996)
• LncRNA SNHG14 aggravates invasion and migration as ceRNA via regulating miR-656-3p/SIRT5 pathway in hepatocellular carcinoma. (PMID:32607966)
• SNHG14 induces osteogenic differentiation of human stromal (mesenchymal) stem cells in vitro by downregulating miR-2861. (PMID:32770994)
• LncRNA SNHG14 promotes hepatocellular carcinoma progression via H3K27 acetylation activated PABPC1 by PTEN signaling. (PMID:32811821)
• LncRNA SNHG14 regulates the DDP-resistance of non-small cell lung cancer cell through miR-133a/HOXB13 pathway. (PMID:33059643)
• lncRNA SNHG14 involved in trophoblast cell proliferation, migration, invasion and epithelial-mesenchymal transition by targeting miR-330-5p in preeclampsia. (PMID:33161910)
• Long noncoding RNA SNHG14 affects the proliferation and apoptosis of childhood acute myeloid leukaemia cells by modulating the miR193b3p/MCL1 axis. (PMID:33300066)
• Long noncoding RNA SNHG14 promotes hepatocellular carcinoma progression by regulating miR-876-5p/SSR2 axis. (PMID:33485374)
• Silence of Long Noncoding RNA SNHG14 Alleviates Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating miR-124-3p/MMP2 Axis. (PMID:33490282)
• Downregulation of lncRNA SNHG14 attenuates osteoarthritis by inhibiting FSTL-1 mediated NLRP3 and TLR4/NF-kappaB pathway through miR-124-3p. (PMID:33539913)
• Blocking SNHG14 Antagonizes Lipopolysaccharides-Induced Acute Lung Injury via SNHG14/miR-124-3p Axis. (PMID:33652176)
• lncRNA SNHG14 promotes oncogenesis and immune evasion in diffuse large-B-cell lymphoma by sequestering miR-152-3p. (PMID:33682607)
• LncRNA SNHG14 Sponges miR-206 to Affect Proliferation, Apoptosis, and Metastasis of Hepatocellular Carcinoma Cells by Regulating SOX9. (PMID:33782806)
• Long non-coding RNA SNHG14 aggravates LPS-induced acute kidney injury through regulating miR-495-3p/HIPK1. (PMID:33856026)
• Mechanism of Autonomic Exercise Improving Cognitive Function of Alzheimer’s Disease by Regulating lncRNA SNHG14. (PMID:34338033)
• lncRNA SNHG14 promotes the proliferation, migration, and invasion of thyroid tumour cells by regulating miR-93-5p. (PMID:34380584)
• LncRNA SNHG14 contributes to proinflammatory cytokine production in rheumatoid arthritis via the regulation of the miR-17-5p/MINK1-JNK pathway. (PMID:34529319)
• lncRNA-SNHG14 Plays a Role in Acute Lung Injury Induced by Lipopolysaccharide through Regulating Autophagy via miR-223-3p/Foxo3a. (PMID:34539244)
• LncRNA SNHG14 accelerates breast cancer progression through sponging miR-543 and regulating KLF7 expression. (PMID:34783894)
• Prognostic Significance of Long Non Coding RNA ANRIL and SNHG14 in Acute Myeloid Leukemia. (PMID:34967554)
• LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR-29c. (PMID:35078502)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.