SNHG17

Summary

SNHG17 (small nucleolar RNA host gene 17, HGNC:48600) is a long non-coding RNA gene on chromosome 20q11.23.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 388796 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48600
Approved symbol	SNHG17
Name	small nucleolar RNA host gene 17
Location	20q11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000196756
Ensembl biotype	lncRNA
OMIM	620808
Entrez	388796
RNAcentral	URS00026A1B07 — lncRNA, 1086 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 182 — 182 lncRNA

ENST00000413755, ENST00000414142, ENST00000417578, ENST00000423536, ENST00000424235, ENST00000436764, ENST00000449469, ENST00000456953, ENST00000651115, ENST00000653277, ENST00000653343, ENST00000653697, ENST00000653753, ENST00000653938, ENST00000654008, ENST00000654092, ENST00000654183, ENST00000654389, ENST00000654853, ENST00000655198, ENST00000655311, ENST00000655520, ENST00000655692, ENST00000656023, ENST00000656320, ENST00000657216, ENST00000657429, ENST00000657665, ENST00000657843, ENST00000657868, ENST00000658051, ENST00000658076, ENST00000658141, ENST00000658324, ENST00000658455, ENST00000658488, ENST00000658905, ENST00000659102, ENST00000659186, ENST00000659255, ENST00000659400, ENST00000659753, ENST00000660064, ENST00000660189, ENST00000660558, ENST00000660885, ENST00000661252, ENST00000662213, ENST00000662568, ENST00000662572, ENST00000662982, ENST00000663187, ENST00000663534, ENST00000663540, ENST00000663784, ENST00000663955, ENST00000664073, ENST00000664626, ENST00000664636, ENST00000664964, ENST00000665003, ENST00000665181, ENST00000665233, ENST00000665440, ENST00000665693, ENST00000665735, ENST00000666225, ENST00000666268, ENST00000666331, ENST00000666419, ENST00000666549, ENST00000666806, ENST00000667188, ENST00000667282, ENST00000667412, ENST00000667835, ENST00000667912, ENST00000668042, ENST00000668054, ENST00000668482, ENST00000669033, ENST00000669114, ENST00000669137, ENST00000669405, ENST00000669480, ENST00000670051, ENST00000670958, ENST00000671249, ENST00000671309, ENST00000686145, ENST00000686814, ENST00000686971, ENST00000687490, ENST00000687532, ENST00000688133, ENST00000688336, ENST00000689414, ENST00000689917, ENST00000690361, ENST00000690441, ENST00000691280, ENST00000691314, ENST00000691368, ENST00000691386, ENST00000692262, ENST00000693227, ENST00000693250, ENST00000693665, ENST00000693684, ENST00000701239, ENST00000701507, ENST00000701521, ENST00000701736, ENST00000701793, ENST00000701819, ENST00000701941, ENST00000701987, ENST00000702019, ENST00000781191, ENST00000781192, ENST00000781193, ENST00000781194, ENST00000781195, ENST00000781196, ENST00000781197, ENST00000781198, ENST00000781199, ENST00000781200, ENST00000781201, ENST00000781202, ENST00000781203, ENST00000781204, ENST00000781205, ENST00000781206, ENST00000781207, ENST00000781208, ENST00000781209, ENST00000781210, ENST00000781211, ENST00000781212, ENST00000781213, ENST00000781214, ENST00000781215, ENST00000781216, ENST00000781217, ENST00000781218, ENST00000781219, ENST00000781220, ENST00000781221, ENST00000781222, ENST00000781223, ENST00000781224, ENST00000781225, ENST00000781226, ENST00000781227, ENST00000781228, ENST00000781229, ENST00000781230, ENST00000781231, ENST00000781232, ENST00000781233, ENST00000781234, ENST00000781235, ENST00000781236, ENST00000781237, ENST00000781238, ENST00000781239, ENST00000781240, ENST00000781241, ENST00000781242, ENST00000781243, ENST00000781244, ENST00000781245, ENST00000781246, ENST00000781247, ENST00000781248, ENST00000781249, ENST00000781250, ENST00000781251, ENST00000781252, ENST00000781253, ENST00000781254

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413755 — 7 exons

Exon	Start	End
ENSE00001418029	38421006	38421098
ENSE00001420154	38431041	38431112
ENSE00001420832	38426419	38426503
ENSE00001690715	38422092	38422241
ENSE00001703260	38420588	38420900
ENSE00001779939	38425935	38426048
ENSE00004153154	38435027	38435353

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 97.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 53.0624 / max 1011.3940, expressed in 1820 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187251	53.0624	1820
187249	0.4441	74

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.90	gold quality
lower esophagus mucosa	UBERON:0035834	97.13	gold quality
colonic epithelium	UBERON:0000397	95.94	gold quality
stromal cell of endometrium	CL:0002255	92.96	gold quality
skin of abdomen	UBERON:0001416	92.91	gold quality
skin of leg	UBERON:0001511	92.47	gold quality
left uterine tube	UBERON:0001303	91.95	gold quality
right ovary	UBERON:0002118	91.85	gold quality
left ovary	UBERON:0002119	91.72	gold quality
mucosa of transverse colon	UBERON:0004991	91.59	gold quality
tibial nerve	UBERON:0001323	91.43	gold quality
omental fat pad	UBERON:0010414	91.38	gold quality
oocyte	CL:0000023	91.37	gold quality
peritoneum	UBERON:0002358	91.36	gold quality
esophagus mucosa	UBERON:0002469	91.22	gold quality
body of pancreas	UBERON:0001150	90.90	gold quality
body of uterus	UBERON:0009853	90.35	gold quality
adipose tissue of abdominal region	UBERON:0007808	90.23	gold quality
zone of skin	UBERON:0000014	90.18	gold quality
granulocyte	CL:0000094	90.05	gold quality
body of stomach	UBERON:0001161	90.01	gold quality
minor salivary gland	UBERON:0001830	89.97	gold quality
ectocervix	UBERON:0012249	89.95	gold quality
esophagus	UBERON:0001043	89.93	gold quality
transverse colon	UBERON:0001157	89.76	gold quality
metanephros cortex	UBERON:0010533	89.76	gold quality
mucosa of stomach	UBERON:0001199	89.71	gold quality
left lobe of thyroid gland	UBERON:0001120	89.59	gold quality
endocervix	UBERON:0000458	89.57	gold quality
right coronary artery	UBERON:0001625	89.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 25)

• lncRNA SNHG17 is upregulated in CRC tissues and correlates with poor prognosis, thereby potentially representing an unfavourable prognostic factor for CRC patients. (PMID:28933484)
• SNHG17 acting as a noncoding oncogene in gastric cancer tumorigenesis, promoting gastric cancer progression by epigenetically silencing of p15 and p57. (PMID:30256413)
• findings indicated that SNHG17 was a novel molecule involved in Gastric Cancer progression, providing a potential prognostic biomarker for GC patients. (PMID:30779073)
• SNHG17 expression is negatively correlated with high-density lipoprotein cholesterol in type 2 diabetes mellitus. (PMID:31509021)
• STAT3-induced upregulation of lncRNA SNHG17 predicts a poor prognosis of melanoma and promotes cell proliferation and metastasis through regulating PI3K-AKT pathway. (PMID:31599425)
• SNHG17 enhances the malignant characteristics of tongue squamous cell carcinoma by acting as a competing endogenous RNA on microRNA-876 and thereby increasing specificity protein 1 expression. (PMID:32089063)
• H. pylori infection alters repair of DNA double-strand breaks via SNHG17. (PMID:32538894)
• Long non-coding RNA SNHG17 promotes proliferation, migration and invasion of glioma cells by regulating the miR-23b-3p/ZHX1 axis. (PMID:32602607)
• SNHG17 drives malignant behaviors in astrocytoma by targeting miR-876-5p/ERLIN2 axis. (PMID:32883232)
• LncRNA SNHG17 promotes the progression of oral squamous cell carcinoma by modulating miR-375/PAX6 axis. (PMID:32924983)
• LncRNA SNHG17 acts as a ceRNA of miR-324-3p to contribute the progression of osteosarcoma. (PMID:32933241)
• LncRNA SNHG17 promotes proliferation and invasion of ovarian cancer cells through up-regulating FOXA1. (PMID:33015769)
• SNHG17 upregulates WLS expression to accelerate lung adenocarcinoma progression by sponging miR-485-5p. (PMID:33109341)
• LncRNA SNHG17 predicts poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma. (PMID:34227089)
• LncRNA SNHG17 regulates cell proliferation and invasion by targeting miR-338-3p/SOX4 axis in esophageal squamous cell carcinoma. (PMID:34429400)
• LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular Carcinoma. (PMID:34557456)
• LncRNA SNHG17 interacts with LRPPRC to stabilize c-Myc protein and promote G1/S transition and cell proliferation. (PMID:34671012)
• SNHG17, as an EMT-related lncRNA, promotes the expression of c-Myc by binding to c-Jun in esophageal squamous cell carcinoma. (PMID:34714590)
• Integrative Analysis and Experimental Validation Indicated That SNHG17 Is a Prognostic Marker in Prostate Cancer and a Modulator of the Tumor Microenvironment via a Competitive Endogenous RNA Regulatory Network. (PMID:35864871)
• Low SP1 SUMOylation-dependent SNHG17 upregulation promotes drug resistance of gastric cancer through impairing hsa-miR-23b-3p-induced Notch2 inhibition. (PMID:36214997)
• Silencing of lncRNA SNHG17 inhibits the tumorigenesis of epithelial ovarian cancer through regulation of miR-485-5p/AKT1 axis. (PMID:36399797)
• Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation. (PMID:36635762)
• Identification of two novel lipid metabolism-related long non-coding RNAs (SNHG17 and LINC00837) as potential signatures for osteosarcoma prognosis and precise treatment. (PMID:37231440)
• SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma. (PMID:38098044)
• Tumour-derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13-CCR2-M2 macrophage axis. (PMID:38680032)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.