SNHG18

Summary

SNHG18 (small nucleolar RNA host gene 18, HGNC:49007) is a long non-coding RNA gene on chromosome 5p15.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49007
Approved symbol	SNHG18
Name	small nucleolar RNA host gene 18
Location	5p15.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250786
Ensembl biotype	lncRNA
Entrez	100505806
RNAcentral	URS000075CB75 — lncRNA, 1503 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000508179, ENST00000509788, ENST00000655411, ENST00000702096, ENST00000815268, ENST00000815269, ENST00000815270, ENST00000815271, ENST00000815272, ENST00000815273, ENST00000815274, ENST00000815275, ENST00000815276, ENST00000815277, ENST00000815278, ENST00000815279, ENST00000815280, ENST00000815281, ENST00000815282, ENST00000815283, ENST00000815284, ENST00000815285, ENST00000815286, ENST00000815287, ENST00000815288, ENST00000815289

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508179 — 3 exons

Exon	Start	End
ENSE00002062591	9548990	9549149
ENSE00003981547	9549302	9550725
ENSE00004217095	9546176	9546530

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 95.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.4493 / max 94.3559, expressed in 1227 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55682	11.3103	1195
55681	1.1390	735

Top tissues by expression

136 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	95.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.62	gold quality
body of pancreas	UBERON:0001150	93.45	gold quality
right coronary artery	UBERON:0001625	91.64	gold quality
ascending aorta	UBERON:0001496	91.53	gold quality
thoracic aorta	UBERON:0001515	91.46	gold quality
ectocervix	UBERON:0012249	91.46	gold quality
endocervix	UBERON:0000458	91.32	gold quality
prostate gland	UBERON:0002367	91.18	gold quality
pituitary gland	UBERON:0000007	91.12	gold quality
adenohypophysis	UBERON:0002196	90.86	gold quality
descending thoracic aorta	UBERON:0002345	90.78	gold quality
minor salivary gland	UBERON:0001830	90.55	gold quality
saliva-secreting gland	UBERON:0001044	90.43	gold quality
vagina	UBERON:0000996	90.16	gold quality
transverse colon	UBERON:0001157	89.92	gold quality
body of uterus	UBERON:0009853	89.64	gold quality
uterine cervix	UBERON:0000002	89.60	gold quality
left ovary	UBERON:0002119	89.46	gold quality
left coronary artery	UBERON:0001626	89.21	gold quality
stromal cell of endometrium	CL:0002255	89.06	gold quality
right atrium auricular region	UBERON:0006631	88.60	gold quality
right ovary	UBERON:0002118	88.31	gold quality
apex of heart	UBERON:0002098	88.06	gold quality
ovary	UBERON:0000992	87.79	gold quality
myometrium	UBERON:0001296	87.66	gold quality
lower esophagus mucosa	UBERON:0035834	87.29	gold quality
heart	UBERON:0000948	87.23	gold quality
popliteal artery	UBERON:0002250	87.19	gold quality
tibial artery	UBERON:0007610	87.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Small nucleolar RNA host gene 18 might act as a tumor suppressor gene in hepatocellular carcinoma. (PMID:30126319)
• High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma. (PMID:31597158)
• MKL1-induced lncRNA SNHG18 drives the growth and metastasis of non-small cell lung cancer via the miR-211-5p/BRD4 axis. (PMID:33500406)
• Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia. (PMID:38498586)
• Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian aging. (PMID:39272131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.