SNHG20

Summary

SNHG20 (small nucleolar RNA host gene 20, HGNC:33099) is a long non-coding RNA gene on chromosome 17q25.2.

Predicted to be involved in several processes, including cellular response to fatty acid; macrophage activation; and tyrosine phosphorylation of STAT protein. Predicted to be located in nucleolus. Implicated in lung non-small cell carcinoma.

Source: NCBI Gene 654434 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33099
Approved symbol	SNHG20
Name	small nucleolar RNA host gene 20
Location	17q25.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PRO0872, FLJ25582, DKFZp686L05235, SCARNA16HG
Ensembl gene	ENSG00000234912
Ensembl biotype	lncRNA
OMIM	620555
Entrez	654434
RNAcentral	URS000075E632 — lncRNA, 2183 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000366365, ENST00000434411, ENST00000561633, ENST00000564414, ENST00000564509, ENST00000565256, ENST00000566583, ENST00000568056, ENST00000568363, ENST00000569632, ENST00000647734, ENST00000647904, ENST00000648740, ENST00000648926, ENST00000648984, ENST00000649047, ENST00000649712, ENST00000650557

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366365 — 2 exons

Exon	Start	End
ENSE00001710263	77088778	77088949
ENSE00001722220	77089153	77089829

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 92.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 19.8000 / max 262.8603, expressed in 1798 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
162915	19.8000	1798
162916	0.7290	359

Top tissues by expression

274 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.72	gold quality
colonic epithelium	UBERON:0000397	91.35	gold quality
right uterine tube	UBERON:0001302	85.85	gold quality
monocyte	CL:0000576	84.28	gold quality
left lobe of thyroid gland	UBERON:0001120	84.11	gold quality
mononuclear cell	CL:0000842	83.97	gold quality
right lung	UBERON:0002167	83.87	gold quality
right lobe of thyroid gland	UBERON:0001119	83.81	gold quality
leukocyte	CL:0000738	83.39	gold quality
thyroid gland	UBERON:0002046	83.09	gold quality
upper lobe of left lung	UBERON:0008952	83.00	gold quality
lower esophagus mucosa	UBERON:0035834	82.85	gold quality
gastrocnemius	UBERON:0001388	82.82	gold quality
spleen	UBERON:0002106	82.77	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.77	gold quality
cerebellar hemisphere	UBERON:0002245	82.60	gold quality
muscle of leg	UBERON:0001383	82.47	gold quality
body of pancreas	UBERON:0001150	82.39	gold quality
cerebellar cortex	UBERON:0002129	82.39	gold quality
right frontal lobe	UBERON:0002810	82.35	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.33	gold quality
anterior cingulate cortex	UBERON:0009835	82.09	gold quality
cingulate cortex	UBERON:0003027	81.96	gold quality
body of stomach	UBERON:0001161	81.95	gold quality
left adrenal gland cortex	UBERON:0035825	81.92	gold quality
metanephros cortex	UBERON:0010533	81.83	gold quality
mucosa of transverse colon	UBERON:0004991	81.78	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.58	gold quality
upper lobe of lung	UBERON:0008948	81.58	gold quality
right ovary	UBERON:0002118	81.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 26)

• Results show that LncRNA SNHG20 is up-regulated in human colorectal cancer (CRC) tissues and cell lines, correlates with poor prognosis and provide evidence that it participates in CRC progression. (PMID:27543107)
• These results showed that the SNHG20/EZH2/E-cadhein regulator pathway might contribute to the development of novel therapeutic strategies for hepatocellular carcinoma patients. (PMID:28282787)
• rescue experiments indicated that SNHG20 functioned as an oncogene partly via repressing p21 in non-small cell lung cancer (NSCLC) cells. Taken together, our findings demonstrate that SNHG20 is a new candidate for use in NSCLC diagnosis, prognosis and therapy. (PMID:28981099)
• SNHG20 could function as an oncogenic long non-coding RNA by regulating miR-140-5p-ADAM10 axis and MEK/ERK signaling pathway in cervical cancer. (PMID:29604594)
• The lncRNA SNHG20/miR-139/RUNX2 axis modulates the osteosarcoma tumorigenesis and apoptosis via mitochondrial apoptosis pathway, providing a novel insight for the pathophysiological process. (PMID:30072099)
• High SNHG20 expression is associated with enhanced cell migration and invasion in osteosarcoma. (PMID:30120876)
• The important function of SNHG20/miR-197/LIN28 axis in the oncogenesis. (PMID:30394668)
• LncRNA SNHG20 contributes to cell proliferation and invasion by upregulating ZFX expression sponging miR-495-3p in gastric cancer (PMID:30520073)
• Expression level of SNHG20 mRNA in glioma tissues was significantly higher than that in para-carcinoma tissues. After SNHG20 knockout, the protein expressions in the PTEN/PI3K/AKT signaling pathway were inhibited. SNHG20 siRNA transfection significantly inhibited proliferation of U118 and U251 cells with expression of Bax up-regulation and that of Bcl-2 down-regulation. (PMID:30657567)
• HBx promoted the proliferation of hepatocellular carcinoma (HCC) cell and reduced the apoptosis of HCC cells through the SNHG20/PTEN signalling pathway (PMID:30690477)
• Knockdown of SNHG20 suppresses cell proliferation, migration and invasion in non-small cell lung cancer tissue. (PMID:30780105)
• These results suggest that SNHG20 may serve as an independent prognostic predictor and function as a noncoding oncogene in epithelial ovarian cancer progression, which might be a possible novel diagnostic marker and treatment target. (PMID:30846486)
• LncRNA SNHG20 promotes the development of laryngeal squamous cell carcinoma by regulating miR-140. (PMID:31081112)
• LncRNA SNHG20 promoted the proliferation of glioma cells via sponging miR-4486 to regulate the MDM2-p53 pathway. (PMID:31298384)
• SNHG20 expression was decreased in the nonalcoholic fatty liver disease but increased in nonalcoholic fatty liver disease-hepatocellular carcinoma livers.SNHG20 may facilitate the progression of nonalcoholic fatty liver disease to the hepatocellular carcinoma via inducing liver Kupffer cells M2 polarization via STAT6 activation. (PMID:31408278)
• Effects of lncRNA SNHG20 on proliferation and apoptosis of non-small cell lung cancer cells through Wnt/beta-catenin signaling pathway. (PMID:31957836)
• Up-regulated SNHG20 predicts unfavorable prognosis for multiple kinds of cancers. [meta-analysis] (PMID:32118721)
• Knockdown SNHG20 Suppresses Nonsmall Cell Lung Cancer Development by Repressing Proliferation, Migration and Invasion, and Inducing Apoptosis by Regulating miR-2467-3p/E2F3. (PMID:32456448)
• LncRNA SNHG20 enhances the progression of oral squamous cell carcinoma by regulating the miR-29a/DIXDC1/Wnt regulatory axis. (PMID:32495922)
• Knockdown of lncRNA SNHG20 Suppressed the Proliferation of Cholangiocarcinoma by Sponging miR-520f-3p. (PMID:32907346)
• LncRNA SNHG20 promoted proliferation, invasion and inhibited cell apoptosis of lung adenocarcinoma via sponging miR-342 and upregulating DDX49. (PMID:33089952)
• Long noncoding RNA SNHG20 promotes colorectal cancer cell proliferation, migration and invasion via miR495/STAT3 axis. (PMID:33179110)
• Long noncoding RNA SNHG20 promotes cell proliferation, migration and invasion in retinoblastoma via the miR3355p/E2F3 axis. (PMID:34080033)
• Long noncoding RNA SNHG20 regulates cell migration, invasion, and proliferation via the microRNA-19b-3p/RAB14 axis in oral squamous cell carcinoma. (PMID:34282711)
• LncRNA SNHG20 promotes cell proliferation and invasion by suppressing miR-217 in ovarian cancer. (PMID:34302635)
• LncRNA SNHG20 promotes migration and invasion of ovarian cancer via modulating the microRNA-148a/ROCK1 axis. (PMID:34836544)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.