SNHG22

Summary

SNHG22 (small nucleolar RNA host gene 22, HGNC:50285) is a long non-coding RNA gene on chromosome 18q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50285
Approved symbol	SNHG22
Name	small nucleolar RNA host gene 22
Location	18q21.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	SCARNA17HG
Ensembl gene	ENSG00000267322
Ensembl biotype	lncRNA
Entrez	103091864
RNAcentral	URS00001118C6 — lncRNA, 1615 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000589499, ENST00000615535, ENST00000617833, ENST00000782330, ENST00000782331

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000589499 — 4 exons

Exon	Start	End
ENSE00002786192	49814023	49814062
ENSE00002790890	49849637	49851059
ENSE00002825025	49839276	49839364
ENSE00002852967	49840363	49840425

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 99.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 397.0163 / max 10809.8577, expressed in 1823 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170242	397.0163	1823

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	99.56	gold quality
sural nerve	UBERON:0015488	98.74	gold quality
bone marrow cell	CL:0002092	98.03	gold quality
calcaneal tendon	UBERON:0003701	97.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.59	gold quality
adrenal tissue	UBERON:0018303	87.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.24	gold quality
granulocyte	CL:0000094	83.85	gold quality
right lobe of liver	UBERON:0001114	83.14	gold quality
left ovary	UBERON:0002119	80.76	gold quality
right ovary	UBERON:0002118	80.66	gold quality
monocyte	CL:0000576	79.99	gold quality
leukocyte	CL:0000738	79.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	79.06	gold quality
lower esophagus	UBERON:0013473	79.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.57	gold quality
muscle of leg	UBERON:0001383	77.81	gold quality
tibial nerve	UBERON:0001323	77.26	gold quality
adenohypophysis	UBERON:0002196	77.25	gold quality
apex of heart	UBERON:0002098	77.10	gold quality
blood	UBERON:0000178	76.88	gold quality
ascending aorta	UBERON:0001496	76.71	gold quality
tendon	UBERON:0000043	76.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.59	gold quality
liver	UBERON:0002107	76.47	gold quality
thoracic aorta	UBERON:0001515	76.43	gold quality
body of uterus	UBERON:0009853	76.43	gold quality
left uterine tube	UBERON:0001303	76.41	gold quality
lower esophagus mucosa	UBERON:0035834	76.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.68

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• lncRNA SNHG22 sponges miR1283p to promote the progression of colorectal cancer by upregulating E2F3. (PMID:34368861)
• Long non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p. (PMID:34652260)
• ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis. (PMID:34663788)
• SNHG22 promotes migration and invasion of trophoblasts via miR-128-3p/PCDH11X axis and activates PI3K/Akt signaling pathway. (PMID:35679761)
• LncRNA SNHG22 promotes gastric cancer progression by regulating the miR-101-3p/e2f2 axis. (PMID:36281526)
• Detection of serum SNHG22 and its correlation with prognosis of non-small cell lung cancer. (PMID:39300525)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.