SNHG25

Summary

SNHG25 (small nucleolar RNA host gene 25, HGNC:51534) is a long non-coding RNA gene on chromosome 17q23.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 105376843 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51534
Approved symbol	SNHG25
Name	small nucleolar RNA host gene 25
Location	17q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000266402
Ensembl biotype	lncRNA
Entrez	105376843
RNAcentral	URS00008E39A1 — lncRNA, 119 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000580828, ENST00000582965, ENST00000688233, ENST00000776275, ENST00000776278, ENST00000776279, ENST00000776281, ENST00000776283, ENST00000776284

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580828 — 3 exons

Exon	Start	End
ENSE00002690924	64146230	64146309
ENSE00004143775	64145640	64145995
ENSE00004143777	64145208	64145284

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 98.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 59.9323 / max 1119.1928, expressed in 1810 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
162246	59.9323	1810

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	98.53	gold quality
body of pancreas	UBERON:0001150	96.96	gold quality
right uterine tube	UBERON:0001302	96.76	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	96.73	gold quality
left ovary	UBERON:0002119	96.08	gold quality
sural nerve	UBERON:0015488	96.00	gold quality
spleen	UBERON:0002106	95.74	gold quality
right ovary	UBERON:0002118	95.59	gold quality
left adrenal gland cortex	UBERON:0035825	95.44	gold quality
right lung	UBERON:0002167	95.06	gold quality
right adrenal gland	UBERON:0001233	94.95	gold quality
left adrenal gland	UBERON:0001234	94.94	gold quality
right lobe of liver	UBERON:0001114	94.82	gold quality
vagina	UBERON:0000996	94.38	gold quality
prostate gland	UBERON:0002367	94.17	gold quality
right adrenal gland cortex	UBERON:0035827	93.92	gold quality
adrenal tissue	UBERON:0018303	93.79	gold quality
ectocervix	UBERON:0012249	93.74	gold quality
left uterine tube	UBERON:0001303	93.68	gold quality
ovary	UBERON:0000992	93.66	gold quality
adrenal gland	UBERON:0002369	93.65	gold quality
esophagus mucosa	UBERON:0002469	93.62	gold quality
uterine cervix	UBERON:0000002	93.49	gold quality
adenohypophysis	UBERON:0002196	93.47	gold quality
mucosa of transverse colon	UBERON:0004991	93.37	gold quality
body of stomach	UBERON:0001161	93.31	gold quality
duodenum	UBERON:0002114	93.30	gold quality
pituitary gland	UBERON:0000007	93.07	gold quality
endocervix	UBERON:0000458	93.06	gold quality
granulocyte	CL:0000094	92.83	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	15.22
E-MTAB-10596	no	984.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression. (PMID:34789312)
• SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells. (PMID:35821006)
• LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling. (PMID:36071306)
• Small nucleolar RNA host gene 25 is a long non-coding RNA helps diagnose and predict outcomes in prostate cancer. (PMID:36706513)
• Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer. (PMID:37307941)
• SNHG25 promotes colorectal cancer metastasis by regulating MMP2. (PMID:37751586)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.