SNHG26

Summary

SNHG26 (small nucleolar RNA host gene 26, HGNC:53131) is a long non-coding RNA gene on chromosome 7p15.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53131
Approved symbol	SNHG26
Name	small nucleolar RNA host gene 26
Location	7p15.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC005682.5
Ensembl gene	ENSG00000228649
Ensembl biotype	lncRNA
Entrez	109729180
RNAcentral	URS0000BC45DE — lncRNA, 763 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 53 lncRNA, 1 retained_intron

ENST00000415611, ENST00000422542, ENST00000432668, ENST00000656301, ENST00000656687, ENST00000657608, ENST00000658124, ENST00000661147, ENST00000661582, ENST00000662021, ENST00000663057, ENST00000667557, ENST00000671680, ENST00000685098, ENST00000688000, ENST00000689892, ENST00000690219, ENST00000691516, ENST00000702192, ENST00000702518, ENST00000702669, ENST00000702874, ENST00000748431, ENST00000748432, ENST00000748433, ENST00000748434, ENST00000748435, ENST00000748436, ENST00000748437, ENST00000748438, ENST00000748439, ENST00000748440, ENST00000748441, ENST00000748442, ENST00000748443, ENST00000748444, ENST00000748445, ENST00000748446, ENST00000748447, ENST00000748448, ENST00000748449, ENST00000748450, ENST00000748451, ENST00000748452, ENST00000748453, ENST00000748454, ENST00000748455, ENST00000748456, ENST00000748457, ENST00000748458, ENST00000748459, ENST00000748460, ENST00000748461, ENST00000748462

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415611 — 4 exons

Exon	Start	End
ENSE00001700592	22856973	22857016
ENSE00001791243	22856522	22856556
ENSE00004091281	22858571	22861438
ENSE00004091285	22854126	22854280

Expression profiles

Bgee: expression breadth ubiquitous, 196 present calls, max score 89.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.8275 / max 455.5654, expressed in 1536 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77607	6.6805	1527
77608	0.1470	62

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	89.72	gold quality
oviduct epithelium	UBERON:0004804	88.82	gold quality
tendon	UBERON:0000043	86.98	gold quality
lower esophagus mucosa	UBERON:0035834	86.81	gold quality
left uterine tube	UBERON:0001303	84.51	gold quality
mucosa of stomach	UBERON:0001199	84.41	gold quality
body of uterus	UBERON:0009853	83.64	gold quality
lower esophagus	UBERON:0013473	83.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.06	gold quality
body of pancreas	UBERON:0001150	82.98	gold quality
ectocervix	UBERON:0012249	82.41	gold quality
tibial artery	UBERON:0007610	82.39	gold quality
popliteal artery	UBERON:0002250	82.38	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	82.08	gold quality
left coronary artery	UBERON:0001626	81.95	gold quality
muscle of leg	UBERON:0001383	81.82	gold quality
gastrocnemius	UBERON:0001388	81.58	gold quality
aorta	UBERON:0000947	81.53	gold quality
tibial nerve	UBERON:0001323	81.38	gold quality
ascending aorta	UBERON:0001496	81.20	gold quality
vagina	UBERON:0000996	81.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.17	gold quality
tendon of biceps brachii	UBERON:0008188	81.10	silver quality
omental fat pad	UBERON:0010414	80.93	gold quality
peritoneum	UBERON:0002358	80.91	gold quality
thoracic aorta	UBERON:0001515	80.86	gold quality
esophagus	UBERON:0001043	80.71	gold quality
left ovary	UBERON:0002119	80.32	gold quality
right ovary	UBERON:0002118	80.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop. (PMID:38553452)
• The lncRNA SNHG26 drives the inflammatory-to-proliferative state transition of keratinocyte progenitor cells during wound healing. (PMID:39366968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.