SNHG29

Summary

SNHG29 (small nucleolar RNA host gene 29, HGNC:28619) is a long non-coding RNA gene on chromosome 17p11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 125144 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28619
Approved symbol	SNHG29
Name	small nucleolar RNA host gene 29
Location	17p11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ACIL, MGC40157
Ensembl gene	ENSG00000175061
Ensembl biotype	lncRNA
Entrez	125144
RNAcentral	URS000075BC33 — lncRNA, 1338 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 82 — 80 lncRNA, 2 retained_intron

ENST00000460249, ENST00000470491, ENST00000472367, ENST00000475947, ENST00000475953, ENST00000477249, ENST00000478103, ENST00000480811, ENST00000481027, ENST00000481898, ENST00000483140, ENST00000483588, ENST00000484836, ENST00000487066, ENST00000491009, ENST00000492250, ENST00000497774, ENST00000578380, ENST00000578757, ENST00000579473, ENST00000580180, ENST00000580770, ENST00000581361, ENST00000581718, ENST00000581913, ENST00000582911, ENST00000583400, ENST00000584141, ENST00000584177, ENST00000584926, ENST00000653954, ENST00000654356, ENST00000654561, ENST00000654778, ENST00000655540, ENST00000658116, ENST00000658943, ENST00000659884, ENST00000660020, ENST00000660419, ENST00000660462, ENST00000662869, ENST00000663781, ENST00000664939, ENST00000665646, ENST00000666215, ENST00000667979, ENST00000668333, ENST00000669136, ENST00000671170, ENST00000685971, ENST00000686699, ENST00000688805, ENST00000689483, ENST00000689691, ENST00000690854, ENST00000692720, ENST00000692724, ENST00000702366, ENST00000702435, ENST00000702586, ENST00000702674, ENST00000778444, ENST00000778445, ENST00000778446, ENST00000778447, ENST00000778448, ENST00000778449, ENST00000778450, ENST00000778451, ENST00000778452, ENST00000778453, ENST00000778454, ENST00000778455, ENST00000778456, ENST00000778457, ENST00000778458, ENST00000778459, ENST00000778461, ENST00000778462, ENST00000778463, ENST00000778464

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000460249 — 5 exons

Exon	Start	End
ENSE00001857647	16440185	16440253
ENSE00001901107	16439581	16439703
ENSE00001926000	16441074	16442018
ENSE00002084640	16439327	16439414
ENSE00002711615	16439037	16439060

Expression profiles

Bgee: expression breadth ubiquitous, 221 present calls, max score 99.78.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 251.4392 / max 6585.9171, expressed in 1825 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
159703	221.2950	1824
159712	16.4618	1714
159704	4.0456	1543
159707	1.7850	1005
159709	1.7788	999
159711	1.5786	867
208073	1.0872	662
159710	0.8886	506
159706	0.8589	513
159713	0.7224	203

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	99.78	gold quality
cortical plate	UBERON:0005343	99.75	gold quality
left ovary	UBERON:0002119	99.67	gold quality
ventricular zone	UBERON:0003053	99.67	gold quality
skin of abdomen	UBERON:0001416	99.61	gold quality
right ovary	UBERON:0002118	99.61	gold quality
right uterine tube	UBERON:0001302	99.58	gold quality
endocervix	UBERON:0000458	99.57	gold quality
left lobe of thyroid gland	UBERON:0001120	99.57	gold quality
colonic epithelium	UBERON:0000397	99.56	gold quality
right lobe of thyroid gland	UBERON:0001119	99.56	gold quality
body of pancreas	UBERON:0001150	99.55	gold quality
right adrenal gland	UBERON:0001233	99.55	gold quality
skin of leg	UBERON:0001511	99.55	gold quality
left adrenal gland cortex	UBERON:0035825	99.55	gold quality
left adrenal gland	UBERON:0001234	99.53	gold quality
right adrenal gland cortex	UBERON:0035827	99.53	gold quality
metanephros cortex	UBERON:0010533	99.52	gold quality
ectocervix	UBERON:0012249	99.52	gold quality
body of uterus	UBERON:0009853	99.51	gold quality
body of stomach	UBERON:0001161	99.45	gold quality
mucosa of stomach	UBERON:0001199	99.45	gold quality
rectum	UBERON:0001052	99.41	gold quality
transverse colon	UBERON:0001157	99.41	gold quality
lower esophagus mucosa	UBERON:0035834	99.40	gold quality
minor salivary gland	UBERON:0001830	99.39	gold quality
adenohypophysis	UBERON:0002196	99.39	gold quality
mucosa of transverse colon	UBERON:0004991	99.37	gold quality
left uterine tube	UBERON:0001303	99.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	99.35	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10596	no	1635.27
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• LRRC75A-AS1 might serve as an anti-oncogene for colorectal cancer tumorigenesis and advancement. (PMID:31505952)
• Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate BAALC. (PMID:32811810)
• Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. (PMID:33080448)
• LRRC75A-AS1 targets miR-199b-5p/PDCD4 axis to repress multiple myeloma. (PMID:33131397)
• Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation. (PMID:33992804)
• LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression. (PMID:36892427)
• A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development. (PMID:37157016)
• Long non-coding RNA small nucleolar RNA host gene 29 drives chronic myeloid leukemia progression via microRNA-483-3p/Casitas B-lineage Lymphoma axis-mediated activation of the phosphoinositide 3-kinase/Akt pathway. (PMID:38252204)
• Macrophage-enriched novel functional long noncoding RNAs LRRC75A-AS1 and GAPLINC regulate polarization and innate immune responses. (PMID:38592458)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.