SNHG4

Summary

SNHG4 (small nucleolar RNA host gene 4, HGNC:32964) is a long non-coding RNA gene on chromosome 5q31.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32964
Approved symbol	SNHG4
Name	small nucleolar RNA host gene 4
Location	5q31.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	U19H, NCRNA00059
Ensembl gene	ENSG00000281398
Ensembl biotype	lncRNA
OMIM	621088
Entrez	724102
RNAcentral	URS0002617856 — lncRNA, 2070 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000448190, ENST00000505522, ENST00000506188, ENST00000507197, ENST00000507692, ENST00000508735, ENST00000513259, ENST00000514110, ENST00000648842

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000448190 — 5 exons

Exon	Start	End
ENSE00002038320	139274102	139274161
ENSE00002057002	139279549	139279839
ENSE00003762909	139279051	139279129
ENSE00003764992	139278327	139278408
ENSE00003768302	139276121	139276150

Expression profiles

Bgee: expression breadth ubiquitous, 216 present calls, max score 92.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.0268 / max 173.8480, expressed in 1709 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58808	11.0268	1709

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.67	gold quality
lower esophagus mucosa	UBERON:0035834	87.71	gold quality
esophagus mucosa	UBERON:0002469	87.37	gold quality
rectum	UBERON:0001052	85.27	gold quality
vermiform appendix	UBERON:0001154	84.95	gold quality
colonic epithelium	UBERON:0000397	84.28	gold quality
transverse colon	UBERON:0001157	84.16	gold quality
right uterine tube	UBERON:0001302	83.74	gold quality
mucosa of transverse colon	UBERON:0004991	83.70	gold quality
caecum	UBERON:0001153	83.16	gold quality
minor salivary gland	UBERON:0001830	83.02	gold quality
lymph node	UBERON:0000029	82.93	gold quality
gastrocnemius	UBERON:0001388	82.81	gold quality
esophagus	UBERON:0001043	82.56	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.34	gold quality
spleen	UBERON:0002106	82.13	gold quality
muscle of leg	UBERON:0001383	81.53	gold quality
mouth mucosa	UBERON:0003729	80.60	gold quality
adrenal tissue	UBERON:0018303	80.51	gold quality
saliva-secreting gland	UBERON:0001044	80.35	gold quality
tonsil	UBERON:0002372	80.18	gold quality
ectocervix	UBERON:0012249	80.16	gold quality
left uterine tube	UBERON:0001303	79.37	gold quality
vagina	UBERON:0000996	79.16	gold quality
bone marrow cell	CL:0002092	79.14	gold quality
skin of leg	UBERON:0001511	79.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.78	gold quality
body of stomach	UBERON:0001161	78.57	gold quality
sural nerve	UBERON:0015488	78.42	gold quality
metanephros cortex	UBERON:0010533	78.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• Snhg4-pod was detected in urinary sediments from PAN-induced nephrotic rats. Our findings suggest that Snhg4-pod may serve as a novel marker for the diagnosis of glomerular injury (PMID:30597036)
• findings demonstrate that SNHG4 is required by lung cancer cells to maintain malignant phenotype; SNHG4 probably exerts its pro-survival and pro-metastatic effects by sponging anti-tumor miR-98-5p (PMID:31220419)
• SP1-mediated upregulation of lncRNA SNHG4 functions as a ceRNA for miR-377 to facilitate prostate cancer progression through regulation of ZIC5. (PMID:31608997)
• LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells. (PMID:32319862)
• LncRNA SNHG4 regulates miR-138/c-Met axis to promote the proliferation of glioblastoma cells. (PMID:32427712)
• LncRNA SNHG4 promotes the increased growth of endometrial tissue outside the uterine cavity via regulating c-Met mediated by miR-148a-3p. (PMID:32525017)
• LncRNA SNHG4 promotes osteosarcoma proliferation and migration by sponging miR-377-3p. (PMID:32537941)
• LncRNA SNHG4 promotes neuroblastoma proliferation, migration, and invasion by sponging miR-377-3p. (PMID:32614236)
• LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury. (PMID:32982175)
• lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer. (PMID:33236157)
• LncRNA SNHG4 sponges miR-200b to inhibit cell apoptosis in diabetic retinopathy. (PMID:33822671)
• Long noncoding RNA SNHG4 remits lipopolysaccharide-engendered inflammatory lung damage by inhibiting METTL3 - Mediated m(6)A level of STAT2 mRNA. (PMID:34450538)
• Long Non-Coding RNA SNHG4 Is a Potential Diagnostic and Prognostic Indicator in Non-Small Cell Lung Cancer. (PMID:34686507)
• Regulatory Effects of LncRNA SNHG4 on miR-25/FBXW7 Axis in Papillary Thyroid Cancer Cells. (PMID:36004691)
• Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis. (PMID:36565037)
• Long Non-Coding RNA SNHG4 Expression in Women with Endometriosis: A Pilot Study. (PMID:36672893)
• Long Non-Coding RNA Small Nucleolar RNA Host Gene 4 Induced by Transcription Factor SP1 Promoted the Progression of Nasopharyngeal Carcinoma Through Modulating microRNA-510-5p/Centromere Protein F Axis. (PMID:36899270)
• LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network. (PMID:37596700)
• Long non-coding RNA SNHG4 aggravates cigarette smoke-induced COPD by regulating miR-144-3p/EZH2 axis. (PMID:38114929)
• SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis. (PMID:38573492)
• lncRNA SNHG4 inhibits ferroptosis by orchestrating miR-150-5p/c-Myb axis in colorectal cancer. (PMID:38692535)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.