SNHG5

Summary

SNHG5 (small nucleolar RNA host gene 5, HGNC:21026) is a long non-coding RNA gene on chromosome 6q14.3.

This gene represent a snoRNA host gene and produces a long non-coding RNA. This RNA may regulate gene expression by acting as a sponge for microRNAs. This transcript may also stabilize mRNAs by blocking degradation by staufen double-stranded RNA binding protein 1.

Source: NCBI Gene 387066 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21026
Approved symbol	SNHG5
Name	small nucleolar RNA host gene 5
Location	6q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC16362, bA33E24.2, U50HG, NCRNA00044, LINC00044
Ensembl gene	ENSG00000203875
Ensembl biotype	lncRNA
OMIM	613263
Entrez	387066
RNAcentral	URS000075B42D — lncRNA, 524 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 116 — 112 lncRNA, 4 retained_intron

ENST00000369605, ENST00000414002, ENST00000420199, ENST00000425170, ENST00000427501, ENST00000428833, ENST00000431043, ENST00000433843, ENST00000435947, ENST00000453754, ENST00000587692, ENST00000589187, ENST00000622963, ENST00000623001, ENST00000623163, ENST00000623267, ENST00000623650, ENST00000623901, ENST00000623910, ENST00000624128, ENST00000624295, ENST00000625175, ENST00000650155, ENST00000652832, ENST00000654795, ENST00000655116, ENST00000655834, ENST00000655847, ENST00000655881, ENST00000656092, ENST00000656441, ENST00000657203, ENST00000657339, ENST00000657398, ENST00000658077, ENST00000658383, ENST00000658584, ENST00000658742, ENST00000658836, ENST00000658871, ENST00000658919, ENST00000659276, ENST00000659484, ENST00000659725, ENST00000659811, ENST00000660318, ENST00000660580, ENST00000660949, ENST00000661011, ENST00000661360, ENST00000661487, ENST00000662245, ENST00000662914, ENST00000663073, ENST00000663133, ENST00000663448, ENST00000664198, ENST00000664396, ENST00000664449, ENST00000665041, ENST00000665113, ENST00000665270, ENST00000666607, ENST00000666667, ENST00000666912, ENST00000667289, ENST00000667421, ENST00000667545, ENST00000667622, ENST00000667637, ENST00000667693, ENST00000668100, ENST00000668505, ENST00000668512, ENST00000669160, ENST00000669413, ENST00000669678, ENST00000669824, ENST00000670094, ENST00000670327, ENST00000670410, ENST00000671327, ENST00000671650, ENST00000673634, ENST00000673640, ENST00000673721, ENST00000673729, ENST00000673769, ENST00000674091, ENST00000850497, ENST00000850498, ENST00000850499, ENST00000850500, ENST00000850501, ENST00000850502, ENST00000850503, ENST00000850504, ENST00000850505, ENST00000850506, ENST00000850507, ENST00000850508, ENST00000850509, ENST00000850510, ENST00000850511, ENST00000850512, ENST00000850513, ENST00000850514, ENST00000850515, ENST00000850516, ENST00000850517, ENST00000850518, ENST00000850519, ENST00000850520, ENST00000850521, ENST00000850522, ENST00000850523

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000369605 — 5 exons

Exon	Start	End
ENSE00001450426	85677795	85677875
ENSE00001450429	85677954	85678032
ENSE00001625179	85677420	85677492
ENSE00003863796	85678136	85678732
ENSE00003874606	85677082	85677185

Expression profiles

Bgee: expression breadth ubiquitous, 219 present calls, max score 99.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 195.7992 / max 3017.1081, expressed in 1825 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
74615	195.6343	1825
74616	0.1650	64

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	99.53	gold quality
left lobe of thyroid gland	UBERON:0001120	99.47	gold quality
body of pancreas	UBERON:0001150	99.39	gold quality
right lobe of thyroid gland	UBERON:0001119	99.38	gold quality
right ovary	UBERON:0002118	99.37	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.28	gold quality
granulocyte	CL:0000094	99.24	gold quality
skin of abdomen	UBERON:0001416	99.22	gold quality
leukocyte	CL:0000738	99.20	gold quality
monocyte	CL:0000576	99.18	gold quality
endocervix	UBERON:0000458	99.18	gold quality
tibial artery	UBERON:0007610	99.17	gold quality
popliteal artery	UBERON:0002250	99.16	gold quality
rectum	UBERON:0001052	99.15	gold quality
body of uterus	UBERON:0009853	99.15	gold quality
ectocervix	UBERON:0012249	99.13	gold quality
skin of leg	UBERON:0001511	99.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.11	gold quality
ganglionic eminence	UBERON:0004023	99.10	gold quality
mucosa of stomach	UBERON:0001199	99.08	gold quality
vermiform appendix	UBERON:0001154	99.07	gold quality
lower esophagus	UBERON:0013473	99.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	99.06	gold quality
body of stomach	UBERON:0001161	99.01	gold quality
descending thoracic aorta	UBERON:0002345	99.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.00	gold quality
tibial nerve	UBERON:0001323	98.96	gold quality
gastrocnemius	UBERON:0001388	98.93	gold quality
left uterine tube	UBERON:0001303	98.91	gold quality
thoracic aorta	UBERON:0001515	98.91	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-126	yes	2461.51
E-MTAB-10596	no	728.19
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC

Literature-anchored findings (GeneRIF, showing 40)

• the upregulation of serum levels of SNHG5 in patients with malignant melanoma suggest that SNHG55 levels may be a new tumor marker of malignant melanoma (PMID:26440365)
• A positive correlation between KLF4 and SNHG5 expression levels were detected in gastric cancer cells. SNHG5 could directly bind to miR-32 and effectively act as a sponge for miR-32 to modulate the suppression of KLF4. (PMID:27871067)
• Mechanistically, we suggest that SNHG5 stabilizes the target transcripts by blocking their degradation by STAU1. Accordingly, depletion of STAU1 rescues the apoptosis induced after SNHG5 knockdown. Hence, we characterize SNHG5 as a lncRNA promoting tumour cell survival in colorectal cancer. (PMID:28004750)
• the current study revealed novel expression quantitative trait loci (eQTLs) for SNHG5 and PEX6 genes in chromosome 6. Nucleotide substitutions of the eQTLs might be candidate factors for a variety of cancers by regulating expression of the 2 genes. (PMID:28033303)
• Mechanistic investigations demonstrated that SNHG3 functioned as a competing endogenous RNA (ceRNA) to ‘sponge’ miR-182-5p, thus leading to the release of c-Myc from miR-182-5p and modulating the expression of c-Myc. In conclusion, SNHG3 promoted CRC progression via sponging miR-182-5p and upregulating c-Myc and its target genes (PMID:28731158)
• Results show that the levels of small nucleolar RNA host gene 5 (SNHG5) and SRY (sex determining region Y)-box 2 protein (SOX2) were significantly downregulated in osteoarthritis (OA) tissues, while the level of miR-26a was upregulated. (PMID:29409014)
• SNHG5 expression is down-regulated in lung adenocarcinoma patients with acquired gefitinib resistance. (PMID:29592872)
• SNHG5 acts as an oncogene in osteosarcoma via the SNHG5-miR-26a-ROCK1 axis. (PMID:30114643)
• Overexpressed METase promoted cell apoptosis and autophagy via up-regulating the expression of SNHG5 and down-regulating miR-20a in GC (PMID:30227213)
• study suggested that SNHG5 promotes trophoblast cell proliferation, invasion, and migration at least partly via regulating the miR-26a-5p/N-cadherin axis. (PMID:30242892)
• Results indentified two candidate haploinsufficient genes contiguous at 6q14 SYNCRIP (encoding hnRNP-Q) and SNHG5 (that hosts snoRNAs), both involved in regulating RNA maturation and translation inT-cell acute lymphoblastic leukemia (T-ALL). (PMID:30266814)
• High SNHG5 expression is associated with proliferation, metastasis and migration of colorectal cancer. (PMID:30395767)
• LncRNA SNHG5 promotes cisplatin resistance in gastric cancer via inhibiting cell apoptosis. (PMID:31173289)
• Long non-coding RNA SNHG5 promotes glioma progression via miR-205/E2F3 axis. (PMID:31292168)
• downregulated SNHG5 could play a key role in chronic myelogenous leukemia progression. (PMID:31506418)
• lncRNA small nucleolar RNA host gene 5 (SNHG5) is highly expressed in glioblastoma (GBM). SNHG5 promotes GBM cell proliferation and inhibits cell apoptosis in GBM. Yin Yang 1 (YY1) acts as transcriptional activator of SNHG5 in GBM. SNHG5 plays the oncogenic role in GBM by activating p38/MAPK signaling pathway. (PMID:31657621)
• Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia. (PMID:31884339)
• LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis. (PMID:32131767)
• LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD. (PMID:32145584)
• LncRNA SNHG5 regulates SOX4 expression through competitive binding to miR-489-3p in acute myeloid leukemia. (PMID:32266420)
• Long non-coding RNA SNHG5 promotes human hepatocellular carcinoma progression by regulating miR-363-3p/RNF38 axis. (PMID:32329834)
• The functional role, molecular mechanism, and clinical significance of SNHG5 in human cancers are described (review). (PMID:32360843)
• miR-23a-3p regulated by LncRNA SNHG5 suppresses the chondrogenic differentiation of human adipose-derived stem cells via targeting SOX6/SOX5. (PMID:32960357)
• SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer. (PMID:33095847)
• Long non-coding RNA SNHG5 suppresses the development of acute respiratory distress syndrome by targeting miR-205/COMMD1 axis. (PMID:33170429)
• si-SNHG5-FOXF2 inhibits TGF-beta1-induced fibrosis in human primary endometrial stromal cells by the Wnt/beta-catenin signalling pathway. (PMID:33176855)
• LncRNA SNHG5 upregulation induced by YY1 contributes to angiogenesis via miR-26b/CTGF/VEGFA axis in acute myelogenous leukemia. (PMID:33318617)
• LncRNA SNHG5 promotes cervical cancer progression by regulating the miR-132/SOX4 pathway. (PMID:33622094)
• Correlations of SNHG5 genetic polymorphisms with susceptibility and prognosis to gastric cancer in a Chinese population. (PMID:33865958)
• Based on bioinformatics analysis lncrna SNHG5 modulates the function of vascular smooth muscle cells through mir-205-5p/SMAD4 in abdominal aortic aneurysm. (PMID:34185955)
• LncRNA SNHG5 promotes the glycolysis and proliferation of breast cancer cell through regulating BACH1 via targeting miR-299. (PMID:34351577)
• SNHG5 protects chondrocytes in interleukin-1beta-stimulated osteoarthritis via regulating miR-181a-5p/TGFBR3 axis. (PMID:34369033)
• Long Non-Coding RNA Small Nucleolar RNA Host Gene 5 (SNHG5) Regulates Renal Tubular Damage in Diabetic Nephropathy via Targeting MiR-26a-5p. (PMID:34891212)
• SPATS2 is positively activated by long noncoding RNA SNHG5 via regulating DNMT3a expression to promote hepatocellular carcinoma progression. (PMID:35077478)
• MicroRNA-363-3p, negatively regulated by long non-coding RNA small nucleolar RNA host gene 5, inhibits tumor progression by targeting Aurora kinase A in colorectal cancer. (PMID:35166647)
• LncRNA small nucleolar RNA host gene 5 inhibits trophoblast autophagy in preeclampsia by targeting microRNA-31-5p and promoting the transcription of secreted protein acidic and rich in cysteine. (PMID:35259061)
• LncRNA SNHG5 promotes the proliferation and cancer stem cell-like properties of HCC by regulating UPF1 and Wnt-signaling pathway. (PMID:35338348)
• Long non-coding RNA SNHG5 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-212-3p/GDF5/SMAD pathway. (PMID:35346361)
• Long non-coding RNA SNHG5 mediates periodontal inflammation through the NF-kappaB signalling pathway. (PMID:35713268)
• Long Noncoding RNA SNHG5 Induces the NF-kappaB Pathway by Regulating miR-181c-5p/CBX4 Axis to Promote the Progression of Non-Small Cell Lung Cancer. (PMID:35963709)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.