SNHG8

Summary

SNHG8 (small nucleolar RNA host gene 8, HGNC:33098) is a long non-coding RNA gene on chromosome 4q26.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 100093630 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33098
Approved symbol	SNHG8
Name	small nucleolar RNA host gene 8
Location	4q26
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00060, LINC00060
Ensembl gene	ENSG00000269893
Ensembl biotype	lncRNA
Entrez	100093630
RNAcentral	URS000075B0C9 — lncRNA, 653 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000602414, ENST00000602483, ENST00000602520, ENST00000602573, ENST00000602819, ENST00000652022, ENST00000654083, ENST00000665363, ENST00000685544, ENST00000685751, ENST00000688996, ENST00000689575, ENST00000689845, ENST00000693179, ENST00000693401, ENST00000729024, ENST00000729025, ENST00000729026, ENST00000729027, ENST00000729028, ENST00000729029, ENST00000729030, ENST00000729031, ENST00000729032, ENST00000729033, ENST00000729034, ENST00000729035, ENST00000729036, ENST00000729037, ENST00000729038, ENST00000729039, ENST00000729040, ENST00000729041

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602414 — 4 exons

Exon	Start	End
ENSE00003455973	118279389	118279431
ENSE00003859447	118278934	118279137
ENSE00004056127	118278728	118278792
ENSE00004056132	118279624	118279829

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 99.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 126.6619 / max 2787.6970, expressed in 1814 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
49421	122.6568	1814
49420	4.0051	1240

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	99.38	gold quality
left ovary	UBERON:0002119	99.29	gold quality
ovary	UBERON:0000992	99.21	gold quality
right uterine tube	UBERON:0001302	99.02	gold quality
skin of abdomen	UBERON:0001416	98.99	gold quality
right ovary	UBERON:0002118	98.94	gold quality
zone of skin	UBERON:0000014	98.85	gold quality
prostate gland	UBERON:0002367	98.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.82	gold quality
skin of leg	UBERON:0001511	98.81	gold quality
thoracic mammary gland	UBERON:0005200	98.78	gold quality
endocervix	UBERON:0000458	98.76	gold quality
pituitary gland	UBERON:0000007	98.75	gold quality
pancreas	UBERON:0001264	98.75	gold quality
left lobe of thyroid gland	UBERON:0001120	98.72	gold quality
body of stomach	UBERON:0001161	98.72	gold quality
nucleus accumbens	UBERON:0001882	98.71	gold quality
vagina	UBERON:0000996	98.70	gold quality
mucosa of stomach	UBERON:0001199	98.69	gold quality
adenohypophysis	UBERON:0002196	98.68	gold quality
thyroid gland	UBERON:0002046	98.66	gold quality
lower esophagus mucosa	UBERON:0035834	98.66	gold quality
fallopian tube	UBERON:0003889	98.51	gold quality
uterine cervix	UBERON:0000002	98.49	gold quality
fundus of stomach	UBERON:0001160	98.48	gold quality
right lobe of thyroid gland	UBERON:0001119	98.47	gold quality
tibial nerve	UBERON:0001323	98.47	gold quality
saliva-secreting gland	UBERON:0001044	98.44	gold quality
minor salivary gland	UBERON:0001830	98.42	gold quality
omental fat pad	UBERON:0010414	98.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• SNHG8 is highly expressed in endometrial carcinoma, and SNHG8 targets c-MET through miR-152 to regulate the proliferation of endometrial cancer cells. (PMID:29630089)
• These data indicate the pro-oncogenic potential of SNHG8 in EBV-associated gastric carcinoma, meaning it is a latent therapeutic target for the treatment of this type of cancer. (PMID:29736176)
• The expression levels of lncRNA SNHG8 were dramatically increased in hepatocellular carcinoma (HCC) tissues and cell lines as compared with the adjacent normal tissues, and SNHG8 expression was an independent prognostic factor of tumor recurrence in HCC patients. SNHG8 acted as a sponge of miR-149 and counteracted the tumor suppressive effects of mi R-149. (PMID:30537734)
• SNHG8 was up-regulated in colorectal cancer and promoted the proliferation, migration, and invasion of colorectal cancer by sponging miR-663. (PMID:31152930)
• identified as a key regulator of acute myocardial infarction by RNA-seq analysis (PMID:31739782)
• LncRNA SNHG8 accelerates proliferation and inhibits apoptosis in HPV-induced cervical cancer through recruiting EZH2 to epigenetically silence RECK expression. (PMID:31961005)
• Long noncoding RNA SNHG8 promotes the proliferation of osteosarcoma cells by downregulating miR-542-3p. (PMID:32450677)
• LncRNA SNHG8 induces ovarian carcinoma cells cellular process and stemness through Wnt/beta-catenin pathway. (PMID:32538821)
• lncRNA SNHG8 promotes aggressive behaviors of nasopharyngeal carcinoma via regulating miR-656-3p/SATB1 axis. (PMID:32920509)
• LncRNA SNHG8 promotes cell migration and invasion in breast cancer cell through miR-634/ZBTB20 axis. (PMID:33275231)
• Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7. (PMID:33450101)
• Loss of lncRNA SNHG8 promotes epithelial-mesenchymal transition by destabilizing CDH1 mRNA. (PMID:33754289)
• Small nucleolar RNA host gene 8: A rising star in the targets for cancer therapy. (PMID:33894626)
• Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis. (PMID:34362407)
• Differentiated expression of long non-coding RNA-small nucleolar RNA host gene 8 in atherosclerosis and its molecular mechanism. (PMID:34558393)
• Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis. (PMID:35067159)
• SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis. (PMID:35080988)
• YY1-induced long non-coding RNA small nucleolar RNA host gene 8 promotes the tumorigenesis of melanoma via the microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis. (PMID:35156513)
• Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression. (PMID:35354542)
• [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer]. (PMID:36854552)
• A review on the role of SNHG8 in human disorders. (PMID:37043963)
• Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. (PMID:37730840)
• LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK1/2 signaling axis. (PMID:38110485)
• The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients. (PMID:38413635)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.