SNORA105B

Summary

SNORA105B (small nucleolar RNA, H/ACA box 105B, HGNC:51398) is a gene on chromosome 2q33.1.

At a glance

• GWAS associations: 2

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51398
Approved symbol	SNORA105B
Name	small nucleolar RNA, H/ACA box 105B
Location	2q33.1
Locus type	RNA, small nucleolar
Status	Approved
Entrez	106635540
RNAcentral	URS00008E3A35 — snoRNA, 116 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001577817 (2:197488868 CA>C,CAA), RS1002130353 (2:197487049 G>C), RS1005847720 (2:197488107 G>A,T), RS1007439016 (2:197486492 G>T), RS1009509773 (2:197487807 AT>A), RS1011588453 (2:197486423 T>C), RS1013590567 (2:197486710 C>G), RS1015503070 (2:197486337 A>T), RS1015535436 (2:197486676 G>A), RS1017214864 (2:197488553 C>A,T), RS1017555509 (2:197486493 A>G), RS1021019059 (2:197487493 C>T), RS1024004943 (2:197488608 C>G,T), RS1024475240 (2:197488251 G>A), RS1025362653 (2:197486719 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST004521_180	Autism spectrum disorder or schizophrenia	3.000000e-11
GCST004521_275	Autism spectrum disorder or schizophrenia	7.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.