SNORA12

Summary

SNORA12 (small nucleolar RNA, H/ACA box 12, HGNC:32600) is a small nucleolar RNA gene on chromosome 10q24.31.

Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA12, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).

Source: NCBI Gene 677800 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32600
Approved symbol	SNORA12
Name	small nucleolar RNA, H/ACA box 12
Location	10q24.31
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U108
Ensembl gene	ENSG00000212464
Ensembl biotype	snoRNA
OMIM	611330
Entrez	677800
RNAcentral	URS000002084A — snoRNA, 147 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000391162

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000391162 — 1 exons

Exon	Start	End
ENSE00001508946	100237156	100237302

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 99.57.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5901 / max 60.6240, expressed in 318 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111027	0.5901	318

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.57	gold quality
adrenal tissue	UBERON:0018303	99.50	gold quality
granulocyte	CL:0000094	90.51	gold quality
corpus callosum	UBERON:0002336	90.26	gold quality
bone marrow	UBERON:0002371	83.74	gold quality
blood	UBERON:0000178	82.34	gold quality
prefrontal cortex	UBERON:0000451	79.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	79.71	gold quality
calcaneal tendon	UBERON:0003701	79.68	gold quality
monocyte	CL:0000576	79.03	gold quality
kidney	UBERON:0002113	77.68	gold quality
liver	UBERON:0002107	77.56	gold quality
endometrium	UBERON:0001295	76.79	gold quality
left uterine tube	UBERON:0001303	76.69	gold quality
right lung	UBERON:0002167	76.38	gold quality
skeletal muscle tissue	UBERON:0001134	75.74	gold quality
lung	UBERON:0002048	75.34	gold quality
adult mammalian kidney	UBERON:0000082	74.28	gold quality
stomach	UBERON:0000945	74.09	gold quality
left ovary	UBERON:0002119	73.57	gold quality
islet of Langerhans	UBERON:0000006	73.43	gold quality
ovary	UBERON:0000992	73.26	gold quality
endocervix	UBERON:0000458	72.81	gold quality
right ovary	UBERON:0002118	72.72	gold quality
muscle of leg	UBERON:0001383	72.54	gold quality
body of pancreas	UBERON:0001150	72.49	gold quality
ascending aorta	UBERON:0001496	71.99	gold quality
body of uterus	UBERON:0009853	71.98	gold quality
urinary bladder	UBERON:0001255	71.97	gold quality
thoracic aorta	UBERON:0001515	71.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• decreased expression levels in T-cells from patients with systemic lupus erythematosus associated with a higher disease activity score (PMID:29848166)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24336	ENSMUSG00000077391
rattus_norvegicus	Snora12	ENSRNOG00000052607

Paralogs (2): (ENSG00000212175), (ENSG00000212342)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.