SNORA14A

Summary

SNORA14A (small nucleolar RNA, H/ACA box 14A, HGNC:32602) is a small nucleolar RNA gene on chromosome 7q11.23.

Small nucleolar RNAs (snoRNAs) are 60-150 nt long non-coding RNAs, and include two groups: C/D box snoRNAs and H/ACA box snoRNAs. The C/D box snoRNAs are guides for the 2’-O-ribose methylation of rRNAs or snRNAs. The H/ACA box snoRNAs are guides for the isomerization of uridine residues into pseudouridine. This gene belongs to the group of the H/ACA box snoRNAs, and functions in 18S rRNA pseudouridylation at position U966. The gene duplication generates a 91% identical copy on chromosome 1.

Source: NCBI Gene 677801 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32602
Approved symbol	SNORA14A
Name	small nucleolar RNA, H/ACA box 14A
Location	7q11.23
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA14a
Ensembl gene	ENSG00000201643
Ensembl biotype	snoRNA
Entrez	677801
RNAcentral	URS0000481B37 — snoRNA, 134 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000364773

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364773 — 1 exons

Exon	Start	End
ENSE00001439536	75943782	75943916

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 99.09.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.09	gold quality
sural nerve	UBERON:0015488	98.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.29	gold quality
liver	UBERON:0002107	82.15	gold quality
vermiform appendix	UBERON:0001154	81.04	gold quality
prefrontal cortex	UBERON:0000451	79.11	gold quality
blood	UBERON:0000178	78.76	gold quality
kidney	UBERON:0002113	78.74	gold quality
primary visual cortex	UBERON:0002436	78.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.38	gold quality
islet of Langerhans	UBERON:0000006	76.68	gold quality
stomach	UBERON:0000945	76.56	gold quality
corpus callosum	UBERON:0002336	74.88	gold quality
monocyte	CL:0000576	74.48	gold quality
lung	UBERON:0002048	74.25	gold quality
muscle of leg	UBERON:0001383	74.09	gold quality
gastrocnemius	UBERON:0001388	73.84	gold quality
adult mammalian kidney	UBERON:0000082	73.83	gold quality
adrenal gland	UBERON:0002369	72.24	gold quality
calcaneal tendon	UBERON:0003701	71.46	gold quality
bone marrow	UBERON:0002371	71.34	gold quality
nucleus accumbens	UBERON:0001882	70.59	gold quality
lymph node	UBERON:0000029	70.58	gold quality
right lobe of liver	UBERON:0001114	70.28	gold quality
heart	UBERON:0000948	70.03	gold quality
left adrenal gland cortex	UBERON:0035825	70.01	gold quality
body of pancreas	UBERON:0001150	69.95	gold quality
left adrenal gland	UBERON:0001234	69.43	gold quality
caudate nucleus	UBERON:0001873	67.95	gold quality
amygdala	UBERON:0001876	67.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.85

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000117034
mus_musculus	Gm26397	ENSMUSG00000065637
rattus_norvegicus	LOC120098679	ENSRNOG00000053462

Paralogs (2): SNORA14B (ENSG00000207181), (ENSG00000251922)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.