SNORA14B

Summary

SNORA14B (small nucleolar RNA, H/ACA box 14B, HGNC:32603) is a small nucleolar RNA gene on chromosome 1q42.3.

Small nucleolar RNAs (snoRNAs) are 60-150 nt long non-coding RNAs, and include two groups: C/D box snoRNAs and H/ACA box snoRNAs. The C/D box snoRNAs are guides for the 2’-O-ribose methylation of rRNAs or snRNAs. The H/ACA box snoRNAs are guides for the isomerization of uridine residues into pseudouridine. This gene belongs to the group of the H/ACA box snoRNAs, and functions in 18S rRNA pseudouridylation at position U966. The gene duplication generates a 91% identical copy on chromosome 7.

Source: NCBI Gene 677802 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32603
Approved symbol	SNORA14B
Name	small nucleolar RNA, H/ACA box 14B
Location	1q42.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA14b
Ensembl gene	ENSG00000207181
Ensembl biotype	snoRNA
Entrez	677802
RNAcentral	URS00005F2496 — snoRNA, 135 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384452

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384452 — 1 exons

Exon	Start	End
ENSE00001499460	235127803	235127937

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 99.91.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1290 / max 61.7141, expressed in 33 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18116	0.1290	33

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.91	gold quality
adrenal tissue	UBERON:0018303	96.65	gold quality
corpus callosum	UBERON:0002336	92.84	gold quality
calcaneal tendon	UBERON:0003701	89.18	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.85	gold quality
liver	UBERON:0002107	83.89	gold quality
skeletal muscle tissue	UBERON:0001134	83.05	gold quality
prefrontal cortex	UBERON:0000451	81.98	gold quality
superior frontal gyrus	UBERON:0002661	81.43	gold quality
islet of Langerhans	UBERON:0000006	81.11	gold quality
monocyte	CL:0000576	79.59	gold quality
primary visual cortex	UBERON:0002436	78.89	gold quality
bone marrow	UBERON:0002371	77.84	gold quality
kidney	UBERON:0002113	77.64	gold quality
blood	UBERON:0000178	77.20	gold quality
stomach	UBERON:0000945	76.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	75.69	gold quality
muscle of leg	UBERON:0001383	74.64	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
granulocyte	CL:0000094	73.29	gold quality
adult mammalian kidney	UBERON:0000082	72.36	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.24	gold quality
cerebral cortex	UBERON:0000956	71.70	gold quality
frontal cortex	UBERON:0001870	71.70	gold quality
placenta	UBERON:0001987	71.60	gold quality
right lobe of liver	UBERON:0001114	71.56	gold quality
anterior cingulate cortex	UBERON:0009835	71.50	gold quality
endometrium	UBERON:0001295	71.36	gold quality
smooth muscle tissue	UBERON:0001135	71.32	gold quality
lung	UBERON:0002048	70.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.08

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000117034
mus_musculus	Gm26397	ENSMUSG00000065637
rattus_norvegicus	LOC120098679	ENSRNOG00000053462

Paralogs (2): SNORA14A (ENSG00000201643), (ENSG00000251922)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.