SNORA21

Summary

SNORA21 (small nucleolar RNA, H/ACA box 21, HGNC:32611) is a small nucleolar RNA gene on chromosome 17q12.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 619505 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32611
Approved symbol	SNORA21
Name	small nucleolar RNA, H/ACA box 21
Location	17q12
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA21
Ensembl gene	ENSG00000199293
Ensembl biotype	snoRNA
Entrez	619505
RNAcentral	URS00004EA987 — snoRNA, 133 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000362423

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362423 — 1 exons

Exon	Start	End
ENSE00001437186	38852863	38852994

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 99.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 673.5268 / max 10176.1430, expressed in 1828 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165567	673.5268	1828

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.60	gold quality
adrenal tissue	UBERON:0018303	99.39	gold quality
liver	UBERON:0002107	97.59	gold quality
lung	UBERON:0002048	90.07	gold quality
tibial nerve	UBERON:0001323	88.56	gold quality
kidney	UBERON:0002113	88.51	gold quality
adrenal gland	UBERON:0002369	85.32	gold quality
stomach	UBERON:0000945	84.76	gold quality
intestine	UBERON:0000160	84.75	gold quality
adult mammalian kidney	UBERON:0000082	84.15	gold quality
blood	UBERON:0000178	82.84	gold quality
colon	UBERON:0001155	77.15	gold quality
monocyte	CL:0000576	74.89	gold quality
heart	UBERON:0000948	74.30	gold quality
skeletal muscle tissue	UBERON:0001134	70.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.05	gold quality
skin of leg	UBERON:0001511	69.71	gold quality
esophagus mucosa	UBERON:0002469	68.99	gold quality
islet of Langerhans	UBERON:0000006	68.14	gold quality
pancreas	UBERON:0001264	68.08	gold quality
body of pancreas	UBERON:0001150	65.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.86	gold quality
calcaneal tendon	UBERON:0003701	65.68	gold quality
prostate gland	UBERON:0002367	65.67	gold quality
muscle of leg	UBERON:0001383	64.92	gold quality
body of stomach	UBERON:0001161	64.91	gold quality
heart left ventricle	UBERON:0002084	64.76	gold quality
minor salivary gland	UBERON:0001830	64.38	gold quality
left adrenal gland cortex	UBERON:0035825	63.03	gold quality
tibial artery	UBERON:0007610	62.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Results show that SNORA21is overexpressed in colorectal cancer (CRC), and identified oncogenic roles of SNORA21 through enhanced cellular proliferation and tumor invasion. (PMID:28734806)
• Overexpression of SNORA21 significantly suppressed the tumorigenesis of gallbladder cancer. (PMID:31401397)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Snora21	ENSMUSG00000064901
rattus_norvegicus	Snora21	ENSRNOG00000052741

Paralogs (1): SNORA21B (ENSG00000252699)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.