SNORA31

Summary

SNORA31 (small nucleolar RNA, H/ACA box 31, HGNC:32621) is a small nucleolar RNA gene on chromosome 13q14.13.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus. Implicated in brain disease.

Source: NCBI Gene 677814 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32621
Approved symbol	SNORA31
Name	small nucleolar RNA, H/ACA box 31
Location	13q14.13
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA31, SNORA31A
Ensembl gene	ENSG00000199477
Ensembl biotype	snoRNA
OMIM	619378
Entrez	677814
RNAcentral	URS000019135F — snoRNA, 130 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000362607

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362607 — 1 exons

Exon	Start	End
ENSE00003596587	45337480	45337609

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 99.23.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	99.23	gold quality
sural nerve	UBERON:0015488	99.18	gold quality
lower esophagus mucosa	UBERON:0035834	98.64	gold quality
adrenal tissue	UBERON:0018303	98.33	gold quality
granulocyte	CL:0000094	97.11	gold quality
right lobe of liver	UBERON:0001114	95.78	gold quality
vagina	UBERON:0000996	95.76	gold quality
left ovary	UBERON:0002119	95.76	gold quality
omental fat pad	UBERON:0010414	95.44	gold quality
liver	UBERON:0002107	94.96	gold quality
left uterine tube	UBERON:0001303	94.82	gold quality
right ovary	UBERON:0002118	94.81	gold quality
ovary	UBERON:0000992	94.80	gold quality
right lung	UBERON:0002167	94.55	gold quality
ectocervix	UBERON:0012249	94.54	gold quality
pituitary gland	UBERON:0000007	94.32	gold quality
tibial nerve	UBERON:0001323	94.04	gold quality
adenohypophysis	UBERON:0002196	93.75	gold quality
adipose tissue	UBERON:0001013	93.71	gold quality
esophagus mucosa	UBERON:0002469	93.63	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.32	gold quality
bone marrow	UBERON:0002371	93.11	gold quality
monocyte	CL:0000576	92.93	gold quality
endocervix	UBERON:0000458	92.90	gold quality
mucosa of transverse colon	UBERON:0004991	92.80	gold quality
prostate gland	UBERON:0002367	92.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	92.55	gold quality
left lobe of thyroid gland	UBERON:0001120	92.48	gold quality
lung	UBERON:0002048	92.46	gold quality
upper lobe of left lung	UBERON:0008952	92.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Human SNORA31 thus controls central nervous system neuron-intrinsic immunity to HSV-1 by a distinctive mechanism. (PMID:31806906)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm24165	ENSMUSG00000064652
mus_musculus	Snora31	ENSMUSG00000065147
mus_musculus	Gm24240	ENSMUSG00000088410
rattus_norvegicus	Snora31	ENSRNOG00000055553

Paralogs (26): (ENSG00000251802), (ENSG00000251828), (ENSG00000251838), (ENSG00000251858), (ENSG00000251999), (ENSG00000252050), (ENSG00000252096), (ENSG00000252136), (ENSG00000252238), (ENSG00000252291), (ENSG00000252337), (ENSG00000252349), (ENSG00000252433), (ENSG00000252537), (ENSG00000252580), (ENSG00000252582), (ENSG00000252762), (ENSG00000252852), (ENSG00000252888), (ENSG00000252920), (ENSG00000252989), (ENSG00000253013), (ENSG00000253028), (ENSG00000253041), SNORA31B (ENSG00000253051), (ENSG00000253059)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.