SNORA50C

Summary

SNORA50C (small nucleolar RNA, H/ACA box 50C, HGNC:32662) is a small nucleolar RNA gene on chromosome 17q23.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 677842 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32662
Approved symbol	SNORA50C
Name	small nucleolar RNA, H/ACA box 50C
Location	17q23.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA62
Ensembl gene	ENSG00000277887
Ensembl biotype	snoRNA
Entrez	677842
RNAcentral	URS0000726F61 — snoRNA, 133 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000408535

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408535 — 1 exons

Exon	Start	End
ENSE00001565170	64146339	64146471

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 99.73.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3574 / max 15.0808, expressed in 177 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
162249	0.3574	177

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.73	gold quality
adrenal tissue	UBERON:0018303	89.70	gold quality
skeletal muscle tissue	UBERON:0001134	85.13	gold quality
liver	UBERON:0002107	80.14	gold quality
lower esophagus mucosa	UBERON:0035834	79.60	gold quality
blood	UBERON:0000178	77.46	gold quality
hypothalamus	UBERON:0001898	77.29	gold quality
right adrenal gland	UBERON:0001233	73.55	gold quality
ectocervix	UBERON:0012249	73.47	gold quality
lung	UBERON:0002048	73.14	gold quality
right coronary artery	UBERON:0001625	73.10	gold quality
adult mammalian kidney	UBERON:0000082	72.54	gold quality
body of pancreas	UBERON:0001150	72.47	gold quality
muscle of leg	UBERON:0001383	72.37	gold quality
gastrocnemius	UBERON:0001388	72.33	gold quality
amygdala	UBERON:0001876	72.10	gold quality
kidney	UBERON:0002113	72.00	gold quality
esophagus mucosa	UBERON:0002469	70.75	gold quality
left adrenal gland cortex	UBERON:0035825	69.91	gold quality
fundus of stomach	UBERON:0001160	69.85	gold quality
myometrium	UBERON:0001296	69.50	gold quality
left adrenal gland	UBERON:0001234	69.24	gold quality
left ovary	UBERON:0002119	69.11	gold quality
anterior cingulate cortex	UBERON:0009835	69.11	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.98	gold quality
stomach	UBERON:0000945	68.78	gold quality
endometrium	UBERON:0001295	68.68	gold quality
substantia nigra	UBERON:0002038	68.60	gold quality
thoracic mammary gland	UBERON:0005200	68.06	gold quality
prefrontal cortex	UBERON:0000451	67.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNHG25 facilitates SNORA50C accumulation to stabilize HDAC1 in neuroblastoma cells. (PMID:35821006)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm22711	ENSMUSG00000080540
rattus_norvegicus	Snora50c	ENSRNOG00000052344

Paralogs (5): SNORA50A (ENSG00000206952), (ENSG00000252122), (ENSG00000252904), SNORA50B (ENSG00000253007), SNORA50D (ENSG00000280894)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.