SNORA53

Summary

SNORA53 (small nucleolar RNA, H/ACA box 53, HGNC:32646) is a small nucleolar RNA gene on chromosome 12q23.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 677832 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32646
Approved symbol	SNORA53
Name	small nucleolar RNA, H/ACA box 53
Location	12q23.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA53
Ensembl gene	ENSG00000212443
Ensembl biotype	snoRNA
Entrez	677832
RNAcentral	URS000075B5A7 — lncRNA, 250 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000391141

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000391141 — 1 exons

Exon	Start	End
ENSE00001508925	98599635	98599883

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 99.80.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7562 / max 72.5009, expressed in 276 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127553	0.7562	276

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.80	gold quality
sural nerve	UBERON:0015488	98.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.40	gold quality
colonic epithelium	UBERON:0000397	94.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.84	gold quality
bone marrow cell	CL:0002092	84.83	gold quality
tonsil	UBERON:0002372	82.97	gold quality
bone marrow	UBERON:0002371	82.09	gold quality
skeletal muscle tissue	UBERON:0001134	79.92	gold quality
corpus callosum	UBERON:0002336	79.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	78.50	gold quality
liver	UBERON:0002107	78.40	gold quality
mucosa of transverse colon	UBERON:0004991	77.97	gold quality
ganglionic eminence	UBERON:0004023	77.07	gold quality
lung	UBERON:0002048	74.30	gold quality
kidney	UBERON:0002113	74.18	gold quality
blood	UBERON:0000178	74.05	gold quality
right lobe of liver	UBERON:0001114	73.53	gold quality
right ovary	UBERON:0002118	73.24	gold quality
monocyte	CL:0000576	73.21	gold quality
cortex of kidney	UBERON:0001225	73.03	gold quality
left ovary	UBERON:0002119	72.96	gold quality
stomach	UBERON:0000945	72.86	gold quality
ovary	UBERON:0000992	72.57	gold quality
transverse colon	UBERON:0001157	72.28	gold quality
endometrium	UBERON:0001295	72.09	gold quality
vermiform appendix	UBERON:0001154	72.05	gold quality
heart left ventricle	UBERON:0002084	71.94	gold quality
granulocyte	CL:0000094	71.93	gold quality
adrenal gland	UBERON:0002369	71.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.90

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000109437
danio_rerio		ENSDARG00000115852
mus_musculus	Gm24119	ENSMUSG00000077167
rattus_norvegicus	Snora53	ENSRNOG00000056599

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.