SNORA55

Summary

SNORA55 (small nucleolar RNA, H/ACA box 55, HGNC:32649) is a small nucleolar RNA gene on chromosome 1p34.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 677834 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32649
Approved symbol	SNORA55
Name	small nucleolar RNA, H/ACA box 55
Location	1p34.3
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA55
Ensembl gene	ENSG00000201457
Ensembl biotype	snoRNA
Entrez	677834
RNAcentral	URS000027BAE7 — snoRNA, 137 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000364587

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000364587 — 1 exons

Exon	Start	End
ENSE00001439350	39567374	39567508

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 99.40.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.40	gold quality
adrenal tissue	UBERON:0018303	92.15	gold quality
liver	UBERON:0002107	87.66	gold quality
stomach	UBERON:0000945	81.69	gold quality
adrenal gland	UBERON:0002369	80.78	gold quality
right ovary	UBERON:0002118	79.92	gold quality
lung	UBERON:0002048	78.72	gold quality
skeletal muscle tissue	UBERON:0001134	78.39	gold quality
monocyte	CL:0000576	76.57	gold quality
adult mammalian kidney	UBERON:0000082	75.27	gold quality
kidney	UBERON:0002113	74.10	gold quality
islet of Langerhans	UBERON:0000006	74.02	gold quality
heart	UBERON:0000948	73.63	gold quality
body of pancreas	UBERON:0001150	73.10	gold quality
corpus callosum	UBERON:0002336	72.68	gold quality
blood	UBERON:0000178	72.38	gold quality
right atrium auricular region	UBERON:0006631	72.05	gold quality
ovary	UBERON:0000992	71.58	gold quality
gastrocnemius	UBERON:0001388	71.58	gold quality
muscle of leg	UBERON:0001383	71.55	gold quality
popliteal artery	UBERON:0002250	71.27	gold quality
tibial artery	UBERON:0007610	71.17	gold quality
urinary bladder	UBERON:0001255	71.15	gold quality
upper lobe of left lung	UBERON:0008952	70.76	gold quality
left ovary	UBERON:0002119	70.61	gold quality
heart left ventricle	UBERON:0002084	70.55	gold quality
spleen	UBERON:0002106	70.08	gold quality
rectum	UBERON:0001052	69.86	gold quality
lymph node	UBERON:0000029	69.49	gold quality
minor salivary gland	UBERON:0001830	69.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNORA55 was reproducibly detectable in serum samples from prostate cancer (PCa) patients. SNORA55 silencing in PCa cell lines significantly inhibited cell proliferation and migration. Pathway analysis revealed that SNORA55 expression is significantly associated with growth factor signaling and pro-inflammatory cytokine expression in PCa. (PMID:26809501)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000084034
danio_rerio		ENSDARG00000084670
mus_musculus	Gm24620	ENSMUSG00000064558
mus_musculus	Gm25788	ENSMUSG00000064655
mus_musculus	Gm23974	ENSMUSG00000065255
mus_musculus	Gm22154	ENSMUSG00000065778
mus_musculus	Gm26048	ENSMUSG00000087930
mus_musculus	Gm25370	ENSMUSG00000088784
mus_musculus	Gm22889	ENSMUSG00000089264
rattus_norvegicus	LOC120093962	ENSRNOG00000053801
rattus_norvegicus	LOC120094473	ENSRNOG00000060932

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.