SNORA56

Summary

SNORA56 (small nucleolar RNA, H/ACA box 56, HGNC:32650) is a small nucleolar RNA gene on chromosome Xq28.

Biosynthesis of stable cellular RNAs such as tRNAs, rRNAs, snRNAs, and snoRNAs is aided by covalent nucleotide modification after transcription. The modified nucleotides are involved in correct RNA folding, establishment of correct RNA-RNA and RNA-protein interactions, and in the correct function of mature RNAs. The RNA encoded by this gene is thought to mediate the pseudouridylation of residue U1664 of 28S rRNA.

Source: NCBI Gene 677835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32650
Approved symbol	SNORA56
Name	small nucleolar RNA, H/ACA box 56
Location	Xq28
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA56
Ensembl gene	ENSG00000206693
Ensembl biotype	snoRNA
Entrez	677835
RNAcentral	URS00004C6FD8 — snoRNA, 129 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000383966

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000383966 — 1 exons

Exon	Start	End
ENSE00001498976	154774998	154775126

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 89.74.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.74	gold quality
liver	UBERON:0002107	75.69	gold quality
skeletal muscle tissue	UBERON:0001134	71.85	gold quality
adult mammalian kidney	UBERON:0000082	69.95	gold quality
vagina	UBERON:0000996	69.86	gold quality
tibial nerve	UBERON:0001323	69.82	gold quality
fundus of stomach	UBERON:0001160	68.27	gold quality
lung	UBERON:0002048	67.78	gold quality
blood	UBERON:0000178	67.71	gold quality
hypothalamus	UBERON:0001898	67.66	gold quality
left coronary artery	UBERON:0001626	67.56	gold quality
monocyte	CL:0000576	66.55	gold quality
mucosa of stomach	UBERON:0001199	65.89	gold quality
heart	UBERON:0000948	64.49	gold quality
muscle of leg	UBERON:0001383	64.43	gold quality
smooth muscle tissue	UBERON:0001135	64.28	gold quality
esophagus mucosa	UBERON:0002469	63.97	gold quality
adrenal tissue	UBERON:0018303	63.85	gold quality
gastrocnemius	UBERON:0001388	63.83	gold quality
heart left ventricle	UBERON:0002084	63.17	gold quality
islet of Langerhans	UBERON:0000006	62.90	gold quality
skin of abdomen	UBERON:0001416	62.84	gold quality
stomach	UBERON:0000945	62.77	gold quality
right lobe of liver	UBERON:0001114	62.12	gold quality
left ovary	UBERON:0002119	61.93	gold quality
body of pancreas	UBERON:0001150	61.79	gold quality
body of uterus	UBERON:0009853	61.75	gold quality
thoracic mammary gland	UBERON:0005200	61.69	gold quality
left lobe of thyroid gland	UBERON:0001120	61.62	gold quality
tibial artery	UBERON:0007610	61.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SNORA56-mediated pseudouridylation of 28 S rRNA inhibits ferroptosis and promotes colorectal cancer proliferation by enhancing GCLC translation. (PMID:38049865)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000083826

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.