SNORA58

Summary

SNORA58 (small nucleolar RNA, H/ACA box 58, HGNC:32652) is a small nucleolar RNA gene on chromosome 3q22.1.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus. Predicted to be part of RISC complex.

Source: NCBI Gene 677836 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32652
Approved symbol	SNORA58
Name	small nucleolar RNA, H/ACA box 58
Location	3q22.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	ACA58, SNORA58B
Ensembl gene	ENSG00000249020
Ensembl biotype	snoRNA
Entrez	677836
RNAcentral	URS000075E772 — lncRNA, 236 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000505219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000505219 — 1 exons

Exon	Start	End
ENSE00003610893	131479097	131479233

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 99.10.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.40	gold quality
adrenal tissue	UBERON:0018303	86.14	gold quality
liver	UBERON:0002107	83.32	gold quality
adult mammalian kidney	UBERON:0000082	78.16	gold quality
kidney	UBERON:0002113	76.59	gold quality
monocyte	CL:0000576	75.80	gold quality
calcaneal tendon	UBERON:0003701	75.49	gold quality
blood	UBERON:0000178	75.05	gold quality
lymph node	UBERON:0000029	74.67	gold quality
endometrium	UBERON:0001295	74.16	gold quality
left uterine tube	UBERON:0001303	72.83	gold quality
lung	UBERON:0002048	72.40	gold quality
stomach	UBERON:0000945	72.32	gold quality
islet of Langerhans	UBERON:0000006	72.29	gold quality
bone marrow	UBERON:0002371	71.59	gold quality
right lobe of liver	UBERON:0001114	70.29	gold quality
tonsil	UBERON:0002372	69.65	gold quality
body of pancreas	UBERON:0001150	69.42	gold quality
fundus of stomach	UBERON:0001160	69.35	gold quality
heart	UBERON:0000948	69.33	gold quality
left coronary artery	UBERON:0001626	69.09	gold quality
corpus callosum	UBERON:0002336	68.98	gold quality
gastrocnemius	UBERON:0001388	68.91	gold quality
placenta	UBERON:0001987	68.50	gold quality
adrenal gland	UBERON:0002369	67.61	gold quality
body of stomach	UBERON:0001161	67.48	gold quality
urinary bladder	UBERON:0001255	67.47	gold quality
fallopian tube	UBERON:0003889	67.23	gold quality
right adrenal gland cortex	UBERON:0035827	67.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Tumor-educated platelet SNORA58, SNORA68 and SNORD93 as novel diagnostic biomarkers for esophageal cancer. (PMID:37129021)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm54509	ENSMUSG00002076596
rattus_norvegicus	Gm50450	ENSRNOG00000059872

Paralogs (2): (ENSG00000201003), SNORA58B (ENSG00000201129)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.