SNORA66

Summary

SNORA66 (small nucleolar RNA, H/ACA box 66, HGNC:10223) is a small nucleolar RNA gene on chromosome 1p22.1.

This gene encodes a non-coding RNA that functions in the biogenesis of other small nuclear RNAs. This RNA is found in the nucleolus, where it may be involved in the pseudouridylation of 18S ribosomal RNA. This RNA is found associated with the GAR1 protein.

Source: NCBI Gene 26782 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10223
Approved symbol	SNORA66
Name	small nucleolar RNA, H/ACA box 66
Location	1p22.1
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U66
Ensembl gene	ENSG00000207523
Ensembl biotype	snoRNA
Entrez	26782
RNAcentral	URS0000656AFD — snoRNA, 133 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000384792

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384792 — 1 exons

Exon	Start	End
ENSE00001499799	92840719	92840851

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 99.66.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	99.66	gold quality
lower esophagus mucosa	UBERON:0035834	96.86	gold quality
adrenal tissue	UBERON:0018303	96.47	gold quality
ectocervix	UBERON:0012249	94.68	gold quality
right uterine tube	UBERON:0001302	94.26	gold quality
right ovary	UBERON:0002118	94.06	gold quality
left ovary	UBERON:0002119	94.05	gold quality
ovary	UBERON:0000992	93.21	gold quality
endocervix	UBERON:0000458	92.83	gold quality
vagina	UBERON:0000996	92.66	gold quality
tibial nerve	UBERON:0001323	91.60	gold quality
skin of abdomen	UBERON:0001416	91.58	gold quality
body of uterus	UBERON:0009853	91.56	gold quality
myometrium	UBERON:0001296	91.54	gold quality
monocyte	CL:0000576	91.30	gold quality
left uterine tube	UBERON:0001303	90.54	gold quality
zone of skin	UBERON:0000014	90.20	gold quality
left lobe of thyroid gland	UBERON:0001120	89.93	gold quality
minor salivary gland	UBERON:0001830	89.63	gold quality
liver	UBERON:0002107	89.52	gold quality
skin of leg	UBERON:0001511	89.45	gold quality
prostate gland	UBERON:0002367	89.45	gold quality
esophagus mucosa	UBERON:0002469	89.45	gold quality
thoracic mammary gland	UBERON:0005200	89.39	gold quality
thyroid gland	UBERON:0002046	89.25	gold quality
bone marrow	UBERON:0002371	89.22	gold quality
omental fat pad	UBERON:0010414	89.22	gold quality
saliva-secreting gland	UBERON:0001044	89.20	gold quality
spleen	UBERON:0002106	89.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	88.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.60

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm26387	ENSMUSG00000077426
rattus_norvegicus	SNORA66	ENSRNOG00000078195

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.