SNORA69

Summary

SNORA69 (small nucleolar RNA, H/ACA box 69, HGNC:10226) is a small nucleolar RNA gene on chromosome Xq24.

This gene encodes a member of the family of box ACA small nucleolar RNAs, characterized by a consensus ACA motif positioned 3 nucleotides from the 3’ end of the RNAs and a double-hairpin structure. The box ACA small nucleolar RNAs may play a role in rRNA maturation. This gene is co-transcribed with the ribosomal protein L39 gene.

Source: NCBI Gene 26779 — RefSeq curated summary.

At a glance

• Gene type: non-coding (snoRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10226
Approved symbol	SNORA69
Name	small nucleolar RNA, H/ACA box 69
Location	Xq24
Locus type	RNA, small nucleolar
Status	Approved
Aliases	U69
Ensembl gene	ENSG00000206622
Ensembl biotype	snoRNA
Entrez	26779
RNAcentral	URS00002982D8 — snoRNA, 132 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 snoRNA

ENST00000383895

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000383895 — 1 exons

Exon	Start	End
ENSE00001498905	119787353	119787484

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 87.26.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.26	gold quality
lower esophagus mucosa	UBERON:0035834	85.95	gold quality
granulocyte	CL:0000094	85.79	gold quality
adrenal tissue	UBERON:0018303	82.19	gold quality
monocyte	CL:0000576	79.14	gold quality
liver	UBERON:0002107	78.26	gold quality
blood	UBERON:0000178	77.52	gold quality
endocervix	UBERON:0000458	77.49	gold quality
bone marrow	UBERON:0002371	77.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.09	gold quality
skeletal muscle tissue	UBERON:0001134	75.01	gold quality
right lobe of liver	UBERON:0001114	74.72	gold quality
endometrium	UBERON:0001295	73.52	gold quality
islet of Langerhans	UBERON:0000006	73.08	gold quality
lung	UBERON:0002048	72.48	gold quality
esophagus mucosa	UBERON:0002469	72.47	gold quality
vagina	UBERON:0000996	72.46	gold quality
duodenum	UBERON:0002114	72.23	gold quality
skin of abdomen	UBERON:0001416	72.09	gold quality
ectocervix	UBERON:0012249	71.76	gold quality
kidney	UBERON:0002113	71.58	gold quality
cortex of kidney	UBERON:0001225	71.51	gold quality
left adrenal gland cortex	UBERON:0035825	71.51	gold quality
muscle of leg	UBERON:0001383	71.09	gold quality
ascending aorta	UBERON:0001496	71.06	gold quality
vermiform appendix	UBERON:0001154	70.95	gold quality
thoracic aorta	UBERON:0001515	70.94	gold quality
esophagus	UBERON:0001043	70.90	gold quality
left uterine tube	UBERON:0001303	70.85	gold quality
left coronary artery	UBERON:0001626	70.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio		ENSDARG00000082020
mus_musculus	Gm22784	ENSMUSG00000077276
rattus_norvegicus	Snora69	ENSRNOG00000056426
rattus_norvegicus	LOC120099449	ENSRNOG00000061195

Paralogs (1): (ENSG00000212206)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.